Short-term mortality in patients with myocardial injury and myocardial infarction type 1 and type 2

Laura Sarkisian, L. Saaby, T. S. Poulsen, O. Gerke, A. C. Diederichsen, Nikolaj Jangaard, S. Hosbond, K. Thygesen, H. Mickley

Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

Resumé

Introduction: Troponin elevations occur in a myriad of clinical conditions other than myocardial infarction (MI) and imply a poor prognosis. So far, data comparing the short-term outcome in patients with myocardial injury vs. patients with type 1 or type 2 MI are not available Methods: Over a 1-year period we prospectively studied hospitalized patients having cardiac troponin I (cTnI) measured on clinical indication. The diagnosis of type 1 and type 2 MI was according to the universal definition involving a rising and/or falling pattern of cTnI values above the decision limit of 30 ng/L. cTnI elevations above this limit in patients without overt myocardial ischemia were defined as myocardial injury. A 1-month follow-up was done with mortality as endpoint Results: The study covered 1577 consecutive patients with cTnI values >30 ng/L, of whom 360 had a type 1 MI, 119 a type 2 MI and 1089 had myocardial injury. Type 1 MI patients were younger with a median age of 70 (IQR 61-81) yrs, whereas the median ages in type 2 MI and myocardial injury were higher but comparable : 78 (IQR 67-84) vs. 77 (IQR 67-85) yrs. Peak cTnI values, however, were highest in type 1 MI: 3820 (530-19030) ng/L, lower in type 2 MI: 850 (390-3270) ng/L, and smallest in patients with myocardial injury: 90 (50-270) ng/L (p=0.0001). At one-month follow-up 285 patients had died. Mortality in the different subgroups was: 9% (33/360) in type 1 MI, 24% (28/119) in type 2 MI, and 21% (224/1089) in patients with myocardial injury. The results are depicted in the figure (Kaplan-Meier curves, log-rank-test; p-value
OriginalsprogEngelsk
ArtikelnummerA13297
TidsskriftCirculation
Vol/bind132
ISSN0009-7322
StatusUdgivet - 2015
BegivenhedAmerican Heart Association Congress - Orlando, USA
Varighed: 7. nov. 201511. nov. 2015

Konference

KonferenceAmerican Heart Association Congress
LandUSA
ByOrlando
Periode07/11/201511/11/2015

Emneord

  • *heart infarction *heart muscle injury *patient *mortality *resuscitation *human *medical society follow up Kaplan Meier method prognosis heart muscle ischemia hazard ratio regression analysis diagnosis log rank test hospital patient statistical significance troponin troponin I

Citer dette

Sarkisian, Laura ; Saaby, L. ; Poulsen, T. S. ; Gerke, O. ; Diederichsen, A. C. ; Jangaard, Nikolaj ; Hosbond, S. ; Thygesen, K. ; Mickley, H. / Short-term mortality in patients with myocardial injury and myocardial infarction type 1 and type 2. I: Circulation. 2015 ; Bind 132.
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abstract = "Introduction: Troponin elevations occur in a myriad of clinical conditions other than myocardial infarction (MI) and imply a poor prognosis. So far, data comparing the short-term outcome in patients with myocardial injury vs. patients with type 1 or type 2 MI are not available Methods: Over a 1-year period we prospectively studied hospitalized patients having cardiac troponin I (cTnI) measured on clinical indication. The diagnosis of type 1 and type 2 MI was according to the universal definition involving a rising and/or falling pattern of cTnI values above the decision limit of 30 ng/L. cTnI elevations above this limit in patients without overt myocardial ischemia were defined as myocardial injury. A 1-month follow-up was done with mortality as endpoint Results: The study covered 1577 consecutive patients with cTnI values >30 ng/L, of whom 360 had a type 1 MI, 119 a type 2 MI and 1089 had myocardial injury. Type 1 MI patients were younger with a median age of 70 (IQR 61-81) yrs, whereas the median ages in type 2 MI and myocardial injury were higher but comparable : 78 (IQR 67-84) vs. 77 (IQR 67-85) yrs. Peak cTnI values, however, were highest in type 1 MI: 3820 (530-19030) ng/L, lower in type 2 MI: 850 (390-3270) ng/L, and smallest in patients with myocardial injury: 90 (50-270) ng/L (p=0.0001). At one-month follow-up 285 patients had died. Mortality in the different subgroups was: 9{\%} (33/360) in type 1 MI, 24{\%} (28/119) in type 2 MI, and 21{\%} (224/1089) in patients with myocardial injury. The results are depicted in the figure (Kaplan-Meier curves, log-rank-test; p-value",
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author = "Laura Sarkisian and L. Saaby and Poulsen, {T. S.} and O. Gerke and Diederichsen, {A. C.} and Nikolaj Jangaard and S. Hosbond and K. Thygesen and H. Mickley",
year = "2015",
language = "English",
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journal = "Circulation",
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Sarkisian, L, Saaby, L, Poulsen, TS, Gerke, O, Diederichsen, AC, Jangaard, N, Hosbond, S, Thygesen, K & Mickley, H 2015, 'Short-term mortality in patients with myocardial injury and myocardial infarction type 1 and type 2', Circulation, bind 132, A13297.

Short-term mortality in patients with myocardial injury and myocardial infarction type 1 and type 2. / Sarkisian, Laura; Saaby, L.; Poulsen, T. S.; Gerke, O.; Diederichsen, A. C.; Jangaard, Nikolaj; Hosbond, S.; Thygesen, K.; Mickley, H.

I: Circulation, Bind 132, A13297, 2015.

Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

TY - ABST

T1 - Short-term mortality in patients with myocardial injury and myocardial infarction type 1 and type 2

AU - Sarkisian, Laura

AU - Saaby, L.

AU - Poulsen, T. S.

AU - Gerke, O.

AU - Diederichsen, A. C.

AU - Jangaard, Nikolaj

AU - Hosbond, S.

AU - Thygesen, K.

AU - Mickley, H.

PY - 2015

Y1 - 2015

N2 - Introduction: Troponin elevations occur in a myriad of clinical conditions other than myocardial infarction (MI) and imply a poor prognosis. So far, data comparing the short-term outcome in patients with myocardial injury vs. patients with type 1 or type 2 MI are not available Methods: Over a 1-year period we prospectively studied hospitalized patients having cardiac troponin I (cTnI) measured on clinical indication. The diagnosis of type 1 and type 2 MI was according to the universal definition involving a rising and/or falling pattern of cTnI values above the decision limit of 30 ng/L. cTnI elevations above this limit in patients without overt myocardial ischemia were defined as myocardial injury. A 1-month follow-up was done with mortality as endpoint Results: The study covered 1577 consecutive patients with cTnI values >30 ng/L, of whom 360 had a type 1 MI, 119 a type 2 MI and 1089 had myocardial injury. Type 1 MI patients were younger with a median age of 70 (IQR 61-81) yrs, whereas the median ages in type 2 MI and myocardial injury were higher but comparable : 78 (IQR 67-84) vs. 77 (IQR 67-85) yrs. Peak cTnI values, however, were highest in type 1 MI: 3820 (530-19030) ng/L, lower in type 2 MI: 850 (390-3270) ng/L, and smallest in patients with myocardial injury: 90 (50-270) ng/L (p=0.0001). At one-month follow-up 285 patients had died. Mortality in the different subgroups was: 9% (33/360) in type 1 MI, 24% (28/119) in type 2 MI, and 21% (224/1089) in patients with myocardial injury. The results are depicted in the figure (Kaplan-Meier curves, log-rank-test; p-value

AB - Introduction: Troponin elevations occur in a myriad of clinical conditions other than myocardial infarction (MI) and imply a poor prognosis. So far, data comparing the short-term outcome in patients with myocardial injury vs. patients with type 1 or type 2 MI are not available Methods: Over a 1-year period we prospectively studied hospitalized patients having cardiac troponin I (cTnI) measured on clinical indication. The diagnosis of type 1 and type 2 MI was according to the universal definition involving a rising and/or falling pattern of cTnI values above the decision limit of 30 ng/L. cTnI elevations above this limit in patients without overt myocardial ischemia were defined as myocardial injury. A 1-month follow-up was done with mortality as endpoint Results: The study covered 1577 consecutive patients with cTnI values >30 ng/L, of whom 360 had a type 1 MI, 119 a type 2 MI and 1089 had myocardial injury. Type 1 MI patients were younger with a median age of 70 (IQR 61-81) yrs, whereas the median ages in type 2 MI and myocardial injury were higher but comparable : 78 (IQR 67-84) vs. 77 (IQR 67-85) yrs. Peak cTnI values, however, were highest in type 1 MI: 3820 (530-19030) ng/L, lower in type 2 MI: 850 (390-3270) ng/L, and smallest in patients with myocardial injury: 90 (50-270) ng/L (p=0.0001). At one-month follow-up 285 patients had died. Mortality in the different subgroups was: 9% (33/360) in type 1 MI, 24% (28/119) in type 2 MI, and 21% (224/1089) in patients with myocardial injury. The results are depicted in the figure (Kaplan-Meier curves, log-rank-test; p-value

KW - heart infarction heart muscle injury patient mortality resuscitation human medical society follow up Kaplan Meier method prognosis heart muscle ischemia hazard ratio regression analysis diagnosis log rank test hospital patient statistical significance tro

M3 - Conference abstract in journal

VL - 132

JO - Circulation

JF - Circulation

SN - 0009-7322

M1 - A13297

ER -