Shifting Global Exposures to Poly- and Perfluoroalkyl Substances (PFASs) Evident in Longitudinal Birth Cohorts from a Seafood-Consuming Population

Clifton Dassuncao, Xindi C Hu, Flemming Nielsen, Pál Weihe, Philippe Grandjean, Elsie M Sunderland

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Resumé

Rapid declines in legacy poly- and perfluoroalkyl substances (PFASs) have been reported in human populations globally following changes in production since 2000. However, changes in exposure sources are not well understood. Here, we report serum concentrations of 19 PFASs (∑19PFAS) measured in children between 1993 and 2012 from a North Atlantic fishing community (Faroe Islands). Median ∑19PFAS concentrations in children (ages 5-13 years) peaked in 2000 (47.7 ng mL-1) and declined significantly by 14.4% year-1until 2012. Principal component analysis (PCA) identified two groups of PFASs that likely reflect exposures from diverse consumer products and a third group that consisted of perfluorocarboxylic acids (PFCAs) with nine or more carbons (C ≥ 9). These C ≥ 9 PFASs are strongly associated with mercury in children's hair, a well-established proxy for seafood consumption, especially perfluoroundecanoic acid (PFUnDA, r = 0.72). Toxicokinetic modeling shows PFAS exposures from seafood have become increasingly important (53% of perfluorooctanesulfonate, PFOS, in 2012), despite a decline in whale consumption in recent years. We infer that even in a major seafood-consuming population, declines in legacy PFAS exposure after 2000 were achieved by the rapid phase out of PFOS and its precursors in consumer products. These results emphasize the importance of better understanding exposures to replacement PFASs in these sources.

OriginalsprogEngelsk
TidsskriftEnvironmental Science & Technology (Washington)
Vol/bind52
Udgave nummer6
Sider (fra-til)3738–3747
ISSN0013-936X
DOI
StatusUdgivet - 2018

Fingeraftryk

Consumer products
seafood
Mercury
Principal component analysis
Carbon
Acids
fishing community
acid
population decline
whale
hair
serum
principal component analysis
replacement
exposure
carbon
modeling
perfluoroundecanoic acid
perfluorooctane sulfonic acid

Citer dette

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title = "Shifting Global Exposures to Poly- and Perfluoroalkyl Substances (PFASs) Evident in Longitudinal Birth Cohorts from a Seafood-Consuming Population",
abstract = "Rapid declines in legacy poly- and perfluoroalkyl substances (PFASs) have been reported in human populations globally following changes in production since 2000. However, changes in exposure sources are not well understood. Here, we report serum concentrations of 19 PFASs (∑19PFAS) measured in children between 1993 and 2012 from a North Atlantic fishing community (Faroe Islands). Median ∑19PFAS concentrations in children (ages 5-13 years) peaked in 2000 (47.7 ng mL-1) and declined significantly by 14.4{\%} year-1until 2012. Principal component analysis (PCA) identified two groups of PFASs that likely reflect exposures from diverse consumer products and a third group that consisted of perfluorocarboxylic acids (PFCAs) with nine or more carbons (C ≥ 9). These C ≥ 9 PFASs are strongly associated with mercury in children's hair, a well-established proxy for seafood consumption, especially perfluoroundecanoic acid (PFUnDA, r = 0.72). Toxicokinetic modeling shows PFAS exposures from seafood have become increasingly important (53{\%} of perfluorooctanesulfonate, PFOS, in 2012), despite a decline in whale consumption in recent years. We infer that even in a major seafood-consuming population, declines in legacy PFAS exposure after 2000 were achieved by the rapid phase out of PFOS and its precursors in consumer products. These results emphasize the importance of better understanding exposures to replacement PFASs in these sources.",
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Shifting Global Exposures to Poly- and Perfluoroalkyl Substances (PFASs) Evident in Longitudinal Birth Cohorts from a Seafood-Consuming Population. / Dassuncao, Clifton; Hu, Xindi C; Nielsen, Flemming; Weihe, Pál; Grandjean, Philippe; Sunderland, Elsie M.

I: Environmental Science & Technology (Washington), Bind 52, Nr. 6, 2018, s. 3738–3747.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Shifting Global Exposures to Poly- and Perfluoroalkyl Substances (PFASs) Evident in Longitudinal Birth Cohorts from a Seafood-Consuming Population

AU - Dassuncao, Clifton

AU - Hu, Xindi C

AU - Nielsen, Flemming

AU - Weihe, Pál

AU - Grandjean, Philippe

AU - Sunderland, Elsie M

PY - 2018

Y1 - 2018

N2 - Rapid declines in legacy poly- and perfluoroalkyl substances (PFASs) have been reported in human populations globally following changes in production since 2000. However, changes in exposure sources are not well understood. Here, we report serum concentrations of 19 PFASs (∑19PFAS) measured in children between 1993 and 2012 from a North Atlantic fishing community (Faroe Islands). Median ∑19PFAS concentrations in children (ages 5-13 years) peaked in 2000 (47.7 ng mL-1) and declined significantly by 14.4% year-1until 2012. Principal component analysis (PCA) identified two groups of PFASs that likely reflect exposures from diverse consumer products and a third group that consisted of perfluorocarboxylic acids (PFCAs) with nine or more carbons (C ≥ 9). These C ≥ 9 PFASs are strongly associated with mercury in children's hair, a well-established proxy for seafood consumption, especially perfluoroundecanoic acid (PFUnDA, r = 0.72). Toxicokinetic modeling shows PFAS exposures from seafood have become increasingly important (53% of perfluorooctanesulfonate, PFOS, in 2012), despite a decline in whale consumption in recent years. We infer that even in a major seafood-consuming population, declines in legacy PFAS exposure after 2000 were achieved by the rapid phase out of PFOS and its precursors in consumer products. These results emphasize the importance of better understanding exposures to replacement PFASs in these sources.

AB - Rapid declines in legacy poly- and perfluoroalkyl substances (PFASs) have been reported in human populations globally following changes in production since 2000. However, changes in exposure sources are not well understood. Here, we report serum concentrations of 19 PFASs (∑19PFAS) measured in children between 1993 and 2012 from a North Atlantic fishing community (Faroe Islands). Median ∑19PFAS concentrations in children (ages 5-13 years) peaked in 2000 (47.7 ng mL-1) and declined significantly by 14.4% year-1until 2012. Principal component analysis (PCA) identified two groups of PFASs that likely reflect exposures from diverse consumer products and a third group that consisted of perfluorocarboxylic acids (PFCAs) with nine or more carbons (C ≥ 9). These C ≥ 9 PFASs are strongly associated with mercury in children's hair, a well-established proxy for seafood consumption, especially perfluoroundecanoic acid (PFUnDA, r = 0.72). Toxicokinetic modeling shows PFAS exposures from seafood have become increasingly important (53% of perfluorooctanesulfonate, PFOS, in 2012), despite a decline in whale consumption in recent years. We infer that even in a major seafood-consuming population, declines in legacy PFAS exposure after 2000 were achieved by the rapid phase out of PFOS and its precursors in consumer products. These results emphasize the importance of better understanding exposures to replacement PFASs in these sources.

KW - Journal Article

U2 - 10.1021/acs.est.7b06044

DO - 10.1021/acs.est.7b06044

M3 - Journal article

C2 - 29516726

VL - 52

SP - 3738

EP - 3747

JO - Environmental Science & Technology (Washington)

JF - Environmental Science & Technology (Washington)

SN - 0013-936X

IS - 6

ER -