Sex-specific disease modifiers in juvenile myoclonic epilepsy

Amy Shakeshaft; Naim Panjwani; Amber Collingwood; Holly Crudgington; Anna Hall; Danielle M. Andrade; Christoph P. Beier; Choong Yi Fong; Elena Gardella; Joanna Gesche; David A. Greenberg; Khalid Hamandi; Jeanette Koht; Kheng Seang Lim; Rikke S. Møller; Ching Ching Ng; Alessandro Orsini; Mark I. Rees; Guido Rubboli; Kaja K. Selmer; Pasquale Striano; Marte Syvertsen; Rhys H. Thomas; Jana Zarubova; Mark P. Richardson; Lisa J. Strug; Deb K. Pal

doi:10.1038/s41598-022-06324-2

Sex-specific disease modifiers in juvenile myoclonic epilepsy

Amy Shakeshaft, Naim Panjwani, Amber Collingwood, Holly Crudgington, Anna Hall, Danielle M. Andrade, Christoph P. Beier, Choong Yi Fong, Elena Gardella, Joanna Gesche, David A. Greenberg, Khalid Hamandi, Jeanette Koht, Kheng Seang Lim, Rikke S. Møller, Ching Ching Ng, Alessandro Orsini, Mark I. Rees, Guido Rubboli, Kaja K. SelmerPasquale Striano, Marte Syvertsen, Rhys H. Thomas, Jana Zarubova, Mark P. Richardson, Lisa J. Strug, Deb K. Pal

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Abstrakt

Juvenile myoclonic epilepsy (JME) is a common idiopathic generalised epilepsy with variable seizure prognosis and sex differences in disease presentation. Here, we investigate the combined epidemiology of sex, seizure types and precipitants, and their influence on prognosis in JME, through cross-sectional data collected by The Biology of Juvenile Myoclonic Epilepsy (BIOJUME) consortium. 765 individuals met strict inclusion criteria for JME (female:male, 1.8:1). 59% of females and 50% of males reported triggered seizures, and in females only, this was associated with experiencing absence seizures (OR = 2.0, p

Originalsprog	Engelsk
Artikelnummer	2785
Tidsskrift	Scientific Reports
Vol/bind	12
ISSN	2045-2322
DOI	https://doi.org/10.1038/s41598-022-06324-2
Status	Udgivet - 21. feb. 2022

Dokumenter og links

10.1038/s41598-022-06324-2Licens: CC BY

Open Access VersionForlagets udgivne version, 1,88 MBLicens: CC BY

1 Igangværende

BIOJUME: Biology of Juvenile Myoclonic Epilepsy
Beier, C. P. & Gesche, J.
01/07/2019 → …
Projekter: Projekt › Forskning

Citationsformater

Shakeshaft, A., Panjwani, N., Collingwood, A., Crudgington, H., Hall, A., Andrade, D. M., Beier, C. P., Fong, C. Y., Gardella, E., Gesche, J., Greenberg, D. A., Hamandi, K., Koht, J., Lim, K. S., Møller, R. S., Ng, C. C., Orsini, A., Rees, M. I., Rubboli, G., ... Pal, D. K. (2022). Sex-specific disease modifiers in juvenile myoclonic epilepsy. Scientific Reports, 12, [2785]. https://doi.org/10.1038/s41598-022-06324-2

Shakeshaft, Amy ; Panjwani, Naim ; Collingwood, Amber ; Crudgington, Holly ; Hall, Anna ; Andrade, Danielle M. ; Beier, Christoph P. ; Fong, Choong Yi ; Gardella, Elena ; Gesche, Joanna ; Greenberg, David A. ; Hamandi, Khalid ; Koht, Jeanette ; Lim, Kheng Seang ; Møller, Rikke S. ; Ng, Ching Ching ; Orsini, Alessandro ; Rees, Mark I. ; Rubboli, Guido ; Selmer, Kaja K. ; Striano, Pasquale ; Syvertsen, Marte ; Thomas, Rhys H. ; Zarubova, Jana ; Richardson, Mark P. ; Strug, Lisa J. ; Pal, Deb K. / Sex-specific disease modifiers in juvenile myoclonic epilepsy. I: Scientific Reports. 2022 ; Bind 12.

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title = "Sex-specific disease modifiers in juvenile myoclonic epilepsy",

abstract = "Juvenile myoclonic epilepsy (JME) is a common idiopathic generalised epilepsy with variable seizure prognosis and sex differences in disease presentation. Here, we investigate the combined epidemiology of sex, seizure types and precipitants, and their influence on prognosis in JME, through cross-sectional data collected by The Biology of Juvenile Myoclonic Epilepsy (BIOJUME) consortium. 765 individuals met strict inclusion criteria for JME (female:male, 1.8:1). 59% of females and 50% of males reported triggered seizures, and in females only, this was associated with experiencing absence seizures (OR = 2.0, p ",

author = "Amy Shakeshaft and Naim Panjwani and Amber Collingwood and Holly Crudgington and Anna Hall and Andrade, {Danielle M.} and Beier, {Christoph P.} and Fong, {Choong Yi} and Elena Gardella and Joanna Gesche and Greenberg, {David A.} and Khalid Hamandi and Jeanette Koht and Lim, {Kheng Seang} and M{\o}ller, {Rikke S.} and Ng, {Ching Ching} and Alessandro Orsini and Rees, {Mark I.} and Guido Rubboli and Selmer, {Kaja K.} and Pasquale Striano and Marte Syvertsen and Thomas, {Rhys H.} and Jana Zarubova and Richardson, {Mark P.} and Strug, {Lisa J.} and Pal, {Deb K.}",

year = "2022",

month = feb,

day = "21",

doi = "10.1038/s41598-022-06324-2",

language = "English",

volume = "12",

journal = "Scientific Reports",

issn = "2045-2322",

publisher = "Nature Publishing Group",

}

Shakeshaft, A, Panjwani, N, Collingwood, A, Crudgington, H, Hall, A, Andrade, DM, Beier, CP, Fong, CY, Gardella, E, Gesche, J, Greenberg, DA, Hamandi, K, Koht, J, Lim, KS, Møller, RS, Ng, CC, Orsini, A, Rees, MI, Rubboli, G, Selmer, KK, Striano, P, Syvertsen, M, Thomas, RH, Zarubova, J, Richardson, MP, Strug, LJ & Pal, DK 2022, 'Sex-specific disease modifiers in juvenile myoclonic epilepsy', Scientific Reports, bind 12, 2785. https://doi.org/10.1038/s41598-022-06324-2

Sex-specific disease modifiers in juvenile myoclonic epilepsy. / Shakeshaft, Amy; Panjwani, Naim; Collingwood, Amber; Crudgington, Holly; Hall, Anna; Andrade, Danielle M.; Beier, Christoph P.; Fong, Choong Yi; Gardella, Elena; Gesche, Joanna; Greenberg, David A.; Hamandi, Khalid; Koht, Jeanette; Lim, Kheng Seang; Møller, Rikke S.; Ng, Ching Ching; Orsini, Alessandro; Rees, Mark I.; Rubboli, Guido; Selmer, Kaja K.; Striano, Pasquale; Syvertsen, Marte; Thomas, Rhys H.; Zarubova, Jana; Richardson, Mark P.; Strug, Lisa J.; Pal, Deb K.

I: Scientific Reports, Bind 12, 2785, 21.02.2022.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

TY - JOUR

T1 - Sex-specific disease modifiers in juvenile myoclonic epilepsy

AU - Shakeshaft, Amy

AU - Panjwani, Naim

AU - Collingwood, Amber

AU - Crudgington, Holly

AU - Hall, Anna

AU - Andrade, Danielle M.

AU - Beier, Christoph P.

AU - Fong, Choong Yi

AU - Gardella, Elena

AU - Gesche, Joanna

AU - Greenberg, David A.

AU - Hamandi, Khalid

AU - Koht, Jeanette

AU - Lim, Kheng Seang

AU - Møller, Rikke S.

AU - Ng, Ching Ching

AU - Orsini, Alessandro

AU - Rees, Mark I.

AU - Rubboli, Guido

AU - Selmer, Kaja K.

AU - Striano, Pasquale

AU - Syvertsen, Marte

AU - Thomas, Rhys H.

AU - Zarubova, Jana

AU - Richardson, Mark P.

AU - Strug, Lisa J.

AU - Pal, Deb K.

PY - 2022/2/21

Y1 - 2022/2/21

N2 - Juvenile myoclonic epilepsy (JME) is a common idiopathic generalised epilepsy with variable seizure prognosis and sex differences in disease presentation. Here, we investigate the combined epidemiology of sex, seizure types and precipitants, and their influence on prognosis in JME, through cross-sectional data collected by The Biology of Juvenile Myoclonic Epilepsy (BIOJUME) consortium. 765 individuals met strict inclusion criteria for JME (female:male, 1.8:1). 59% of females and 50% of males reported triggered seizures, and in females only, this was associated with experiencing absence seizures (OR = 2.0, p

AB - Juvenile myoclonic epilepsy (JME) is a common idiopathic generalised epilepsy with variable seizure prognosis and sex differences in disease presentation. Here, we investigate the combined epidemiology of sex, seizure types and precipitants, and their influence on prognosis in JME, through cross-sectional data collected by The Biology of Juvenile Myoclonic Epilepsy (BIOJUME) consortium. 765 individuals met strict inclusion criteria for JME (female:male, 1.8:1). 59% of females and 50% of males reported triggered seizures, and in females only, this was associated with experiencing absence seizures (OR = 2.0, p

U2 - 10.1038/s41598-022-06324-2

DO - 10.1038/s41598-022-06324-2

M3 - Journal article

C2 - 35190554

VL - 12

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 2785

ER -

Sex-specific disease modifiers in juvenile myoclonic epilepsy

Abstrakt

Dokumenter og links

Relaterede Projekter

BIOJUME: Biology of Juvenile Myoclonic Epilepsy

Citationsformater