Sex differences in risk factors for retinopathy in non-diabetic men and women: The Tromso Eye Study

G. Bertelsen, T. Peto, H. Lindekleiv, H. Schirmer, M. D. Solbu, I. Toft, A. K. Sjolie, I. Njolstad

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Purpose: To determine the prevalence and risk factors for retinopathy in a nondiabetic population. Methods: The study population included 5869 participants without diabetes aged 38-87years from the TromsO Eye Study, a substudy of the population-based TromsO Study in Norway. Retinal images from both eyes were graded for retinopathy. We collected data on risk factors from self-report questionnaires, clinical examinations, laboratory measurements and case note reviews. The cross-sectional relationship between potential risk factors and retinopathy was assessed using logistic regression analysis. Results: The overall prevalence of retinopathy was 14.8%. Men had a higher prevalence of retinopathy compared with women (15.9% versus 14.0%, p=0.04). In men, retinopathy was associated with hypertension (odds ratio [OR], 1.59; 95% confidence interval [CI], 1.24-2.04) and HbA1c (OR per %, 1.41; 95% CI, 1.01-1.96). In women, retinopathy was associated with age (OR per 10years, 1.32; 95% CI, 1.14-1.52), log-transformed urinary albumin excretion (OR per log unit, 1.46; 95% CI, 1.14-1.87) and hypertension (OR, 1.36; 95% CI, 1.08-1.71). In women, retinopathy was associated with very low levels of urinary albumin excretion (urinary albumin/creatinine ratio >0.43mg/mmol). Conclusion: This study confirms results from previous studies on the strong association between blood pressure and retinopathy. A novel finding is the sex differences in risk factors for retinopathy, suggesting a sex difference in the pathogenesis leading to retinopathy.
OriginalsprogEngelsk
TidsskriftActa Ophthalmologica
Vol/bind92
Udgave nummer4
Sider (fra-til)316-322
ISSN1755-375X
DOI
StatusUdgivet - 2014

Citer dette

Bertelsen, G., Peto, T., Lindekleiv, H., Schirmer, H., Solbu, M. D., Toft, I., ... Njolstad, I. (2014). Sex differences in risk factors for retinopathy in non-diabetic men and women: The Tromso Eye Study. Acta Ophthalmologica, 92(4), 316-322. https://doi.org/10.1111/aos.12199
Bertelsen, G. ; Peto, T. ; Lindekleiv, H. ; Schirmer, H. ; Solbu, M. D. ; Toft, I. ; Sjolie, A. K. ; Njolstad, I. / Sex differences in risk factors for retinopathy in non-diabetic men and women: The Tromso Eye Study. I: Acta Ophthalmologica. 2014 ; Bind 92, Nr. 4. s. 316-322.
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title = "Sex differences in risk factors for retinopathy in non-diabetic men and women: The Tromso Eye Study",
abstract = "Purpose: To determine the prevalence and risk factors for retinopathy in a nondiabetic population. Methods: The study population included 5869 participants without diabetes aged 38-87years from the TromsO Eye Study, a substudy of the population-based TromsO Study in Norway. Retinal images from both eyes were graded for retinopathy. We collected data on risk factors from self-report questionnaires, clinical examinations, laboratory measurements and case note reviews. The cross-sectional relationship between potential risk factors and retinopathy was assessed using logistic regression analysis. Results: The overall prevalence of retinopathy was 14.8{\%}. Men had a higher prevalence of retinopathy compared with women (15.9{\%} versus 14.0{\%}, p=0.04). In men, retinopathy was associated with hypertension (odds ratio [OR], 1.59; 95{\%} confidence interval [CI], 1.24-2.04) and HbA1c (OR per {\%}, 1.41; 95{\%} CI, 1.01-1.96). In women, retinopathy was associated with age (OR per 10years, 1.32; 95{\%} CI, 1.14-1.52), log-transformed urinary albumin excretion (OR per log unit, 1.46; 95{\%} CI, 1.14-1.87) and hypertension (OR, 1.36; 95{\%} CI, 1.08-1.71). In women, retinopathy was associated with very low levels of urinary albumin excretion (urinary albumin/creatinine ratio >0.43mg/mmol). Conclusion: This study confirms results from previous studies on the strong association between blood pressure and retinopathy. A novel finding is the sex differences in risk factors for retinopathy, suggesting a sex difference in the pathogenesis leading to retinopathy.",
author = "G. Bertelsen and T. Peto and H. Lindekleiv and H. Schirmer and Solbu, {M. D.} and I. Toft and Sjolie, {A. K.} and I. Njolstad",
year = "2014",
doi = "10.1111/aos.12199",
language = "English",
volume = "92",
pages = "316--322",
journal = "Acta Ophthalmologica",
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Bertelsen, G, Peto, T, Lindekleiv, H, Schirmer, H, Solbu, MD, Toft, I, Sjolie, AK & Njolstad, I 2014, 'Sex differences in risk factors for retinopathy in non-diabetic men and women: The Tromso Eye Study', Acta Ophthalmologica, bind 92, nr. 4, s. 316-322. https://doi.org/10.1111/aos.12199

Sex differences in risk factors for retinopathy in non-diabetic men and women: The Tromso Eye Study. / Bertelsen, G.; Peto, T.; Lindekleiv, H.; Schirmer, H.; Solbu, M. D.; Toft, I.; Sjolie, A. K.; Njolstad, I.

I: Acta Ophthalmologica, Bind 92, Nr. 4, 2014, s. 316-322.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Sex differences in risk factors for retinopathy in non-diabetic men and women: The Tromso Eye Study

AU - Bertelsen, G.

AU - Peto, T.

AU - Lindekleiv, H.

AU - Schirmer, H.

AU - Solbu, M. D.

AU - Toft, I.

AU - Sjolie, A. K.

AU - Njolstad, I.

PY - 2014

Y1 - 2014

N2 - Purpose: To determine the prevalence and risk factors for retinopathy in a nondiabetic population. Methods: The study population included 5869 participants without diabetes aged 38-87years from the TromsO Eye Study, a substudy of the population-based TromsO Study in Norway. Retinal images from both eyes were graded for retinopathy. We collected data on risk factors from self-report questionnaires, clinical examinations, laboratory measurements and case note reviews. The cross-sectional relationship between potential risk factors and retinopathy was assessed using logistic regression analysis. Results: The overall prevalence of retinopathy was 14.8%. Men had a higher prevalence of retinopathy compared with women (15.9% versus 14.0%, p=0.04). In men, retinopathy was associated with hypertension (odds ratio [OR], 1.59; 95% confidence interval [CI], 1.24-2.04) and HbA1c (OR per %, 1.41; 95% CI, 1.01-1.96). In women, retinopathy was associated with age (OR per 10years, 1.32; 95% CI, 1.14-1.52), log-transformed urinary albumin excretion (OR per log unit, 1.46; 95% CI, 1.14-1.87) and hypertension (OR, 1.36; 95% CI, 1.08-1.71). In women, retinopathy was associated with very low levels of urinary albumin excretion (urinary albumin/creatinine ratio >0.43mg/mmol). Conclusion: This study confirms results from previous studies on the strong association between blood pressure and retinopathy. A novel finding is the sex differences in risk factors for retinopathy, suggesting a sex difference in the pathogenesis leading to retinopathy.

AB - Purpose: To determine the prevalence and risk factors for retinopathy in a nondiabetic population. Methods: The study population included 5869 participants without diabetes aged 38-87years from the TromsO Eye Study, a substudy of the population-based TromsO Study in Norway. Retinal images from both eyes were graded for retinopathy. We collected data on risk factors from self-report questionnaires, clinical examinations, laboratory measurements and case note reviews. The cross-sectional relationship between potential risk factors and retinopathy was assessed using logistic regression analysis. Results: The overall prevalence of retinopathy was 14.8%. Men had a higher prevalence of retinopathy compared with women (15.9% versus 14.0%, p=0.04). In men, retinopathy was associated with hypertension (odds ratio [OR], 1.59; 95% confidence interval [CI], 1.24-2.04) and HbA1c (OR per %, 1.41; 95% CI, 1.01-1.96). In women, retinopathy was associated with age (OR per 10years, 1.32; 95% CI, 1.14-1.52), log-transformed urinary albumin excretion (OR per log unit, 1.46; 95% CI, 1.14-1.87) and hypertension (OR, 1.36; 95% CI, 1.08-1.71). In women, retinopathy was associated with very low levels of urinary albumin excretion (urinary albumin/creatinine ratio >0.43mg/mmol). Conclusion: This study confirms results from previous studies on the strong association between blood pressure and retinopathy. A novel finding is the sex differences in risk factors for retinopathy, suggesting a sex difference in the pathogenesis leading to retinopathy.

U2 - 10.1111/aos.12199

DO - 10.1111/aos.12199

M3 - Journal article

VL - 92

SP - 316

EP - 322

JO - Acta Ophthalmologica

JF - Acta Ophthalmologica

SN - 1755-375X

IS - 4

ER -