Severe ovarian hyperstimulation syndrome after gonadotropin-releasing hormone (GnRH) agonist trigger and "freeze-all" approach in GnRH antagonist protocol

Human Mousavi Fatemi, Biljana Popovic-Todorovic, Peter Humaidan, Shahar Kol, Manish Banker, Paul Devroey, Juan Antonio García-Velasco

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstrakt

OBJECTIVE: To report two cases with GnRH agonist triggering and a freeze-all approach in a GnRH antagonist protocol resulting in the development of severe ovarian hyperstimulation syndrome (OHSS), requiring hospitalization and peritoneal drainage.

DESIGN: Two case reports.

SETTING: A tertiary referral center and an obstetrics and gynecology department of a hospital.

PATIENT(S): Case 1 and case 2: severe OHSS with abdominal distension, ascites development, and hemoconcentration.

INTERVENTION(S): Case 1 and case 2: diagnosed by clinical, hematologic, and ultrasound findings. Hospitalization, IV infusion, and peritoneal drainage.

MAIN OUTCOME MEASURE(S): Symptomatic treatment and prevention of further complication.

RESULT(S): Complete recovery.

CONCLUSION(S): Two cases of severe OHSS after GnRH agonist trigger in a GnRH antagonist protocol without the administration of any hCG for luteal-phase support. Clinicians have to be aware that even the sequential approach to ovarian stimulation with a freeze-all attitude does not completely eliminate OHSS in all patients.

OriginalsprogEngelsk
TidsskriftFertility and Sterility
Vol/bind101
Udgave nummer4
Sider (fra-til)1008-1011
ISSN0015-0282
DOI
StatusUdgivet - 2014
Udgivet eksterntJa

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