Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

Flannick Jason, Christian Fuchsberger, Anubha Mahajan, Tanya M Teslovich, Vineeta Agarwala, Kyle J Gaulton, Lizz Caulkins, Ryan Koesterer, Clement Ma, Loukas Moutsianas, Davis J McCarthy, Manuel A Rivas, John R B Perry, Xueling Sim, Thomas W Blackwell, Neil R Robertson, N William Rayner, Pablo Cingolani, Adam E Locke, Juan Fernandez Tajes & 281 andre Heather M Highland, Josee Dupuis, Peter S Chines, Cecilia M Lindgren, Christopher Hartl, Anne U Jackson, Han Chen, Jeroen R Huyghe, Martijn van de Bunt, Richard D Pearson, Ashish Kumar, Martina Müller-Nurasyid, Niels Grarup, Heather M Stringham, Eric R Gamazon, Jaehoon Lee, Yuhui Chen, Robert A Scott, Jennifer E Below, Peng Chen, Jinyan Huang, Min Jin Go, Michael L Stitzel, Dorota Pasko, Stephen C J Parker, Tibor V Varga, Todd Green, Nicola L Beer, Aaron G Day-Williams, Teresa Ferreira, Tasha Fingerlin, Momoko Horikoshi, Cheng Hu, Iksoo Huh, Mohammad Kamran Ikram, Bong-Jo Kim, Yongkang Kim, Young Jin Kim, Min-Seok Kwon, Juyoung Lee, Selyeong Lee, Keng-Han Lin, Taylor J Maxwell, Yoshihiko Nagai, Xu Wang, Ryan P Welch, Joon Yoon, Weihua Zhang, Nir Barzilai, Benjamin F Voight, Bok-Ghee Han, Christopher P Jenkinson, Teemu Kuulasmaa, Johanna Kuusisto, Alisa Manning, Maggie C Y Ng, Nicholette D Palmer, Beverley Balkau, Alena Stančáková, Hanna E Abboud, Heiner Boeing, Vilmantas Giedraitis, Dorairaj Prabhakaran, Omri Gottesman, James Scott, Jason Carey, Phoenix Kwan, George Grant, Joshua D Smith, Benjamin M Neale, Shaun Purcell, Adam S Butterworth, Joanna M M Howson, Heung Man Lee, Yingchang Lu, Soo-Heon Kwak, Wei Zhao, John Danesh, Vincent K L Lam, Kyong Soo Park, Danish Saleheen, Wing Yee So, Claudia H T Tam, Uzma Afzal, David Aguilar, Rector Arya, Tin Aung, Edmund Chan, Carmen Navarro, Ching-Yu Cheng, Domenico Palli, Adolfo Correa, Joanne E Curran, Dennis Rybin, Vidya S Farook, Sharon P Fowler, Barry I Freedman, Michael Griswold, Daniel Esten Hale, Pamela J Hicks, Chiea-Chuen Khor, Satish Kumar, Benjamin Lehne, Dorothée Thuillier, Wei Yen Lim, Jianjun Liu, Marie Loh, Solomon K Musani, Sobha Puppala, William R Scott, Loïc Yengo, Sian-Tsung Tan, Herman A Taylor, Farook Thameem, Gregory Wilson, Tien Yin Wong, Pål Rasmus Njølstad, Jonathan C Levy, Massimo Mangino, Lori L Bonnycastle, Thomas Schwarzmayr, João Fadista, Gabriela L Surdulescu, Christian Herder, Christopher J Groves, Thomas Wieland, Jette Bork-Jensen, Ivan Brandslund, Cramer Christensen, Heikki A Koistinen, Alex S F Doney, Leena Kinnunen, Tõnu Esko, Andrew J Farmer, Liisa Hakaste, Dylan Hodgkiss, Jasmina Kravic, Valeri Lyssenko, Mette Hollensted, Marit E Jørgensen, Torben Jørgensen, Claes Ladenvall, Johanne Marie Justesen, Annemari Käräjämäki, Jennifer Kriebel, Wolfgang Rathmann, Lars Lannfelt, Torsten Lauritzen, Narisu Narisu, Allan Linneberg, Olle Melander, Lili Milani, Matt Neville, Marju Orho-Melander, Lu Qi, Qibin Qi, Michael Roden, Olov Rolandsson, Amy Swift, Anders H Rosengren, Kathleen Stirrups, Andrew R Wood, Evelin Mihailov, Christine Blancher, Mauricio O Carneiro, Jared Maguire, Ryan Poplin, Khalid Shakir, Timothy Fennell, Mark DePristo, Martin Hrabé de Angelis, Panos Deloukas, Anette P Gjesing, Goo Jun, Peter Nilsson, Jacquelyn Murphy, Robert Onofrio, Barbara Thorand, Torben Hansen, Christa Meisinger, Frank B Hu, Bo Isomaa, Fredrik Karpe, Liming Liang, Annette Peters, Cornelia Huth, Stephen P O'Rahilly, Colin N A Palmer, Oluf Pedersen, Rainer Rauramaa, Jaakko Tuomilehto, Veikko Salomaa, Richard M Watanabe, Ann-Christine Syvänen, Richard N Bergman, Dwaipayan Bharadwaj, Erwin P Bottinger, Yoon Shin Cho, Giriraj R Chandak, Juliana Cn Chan, Kee Seng Chia, Mark J Daly, Shah B Ebrahim, Claudia Langenberg, Paul Elliott, Kathleen A Jablonski, Donna M Lehman, Weiping Jia, Ronald C W Ma, Toni I Pollin, Manjinder Sandhu, Nikhil Tandon, Philippe Froguel, Inês Barroso, Yik Ying Teo, Eleftheria Zeggini, Ruth J F Loos, Kerrin S Small, Janina S Ried, Ralph A DeFronzo, Harald Grallert, Benjamin Glaser, Andres Metspalu, Nicholas J Wareham, Mark Walker, Eric Banks, Christian Gieger, Erik Ingelsson, Hae Kyung Im, Thomas Illig, Paul W Franks, Gemma Buck, Joseph Trakalo, David Buck, Inga Prokopenko, Reedik Mägi, Lars Lind, Yossi Farjoun, Katharine R Owen, Anna L Gloyn, Konstantin Strauch, Tiinamaija Tuomi, Jaspal Singh Kooner, Jong-Young Lee, Taesung Park, Peter Donnelly, Andrew D Morris, Andrew T Hattersley, Donald W Bowden, Francis S Collins, Gil Atzmon, John C Chambers, Timothy D Spector, Markku Laakso, Tim M Strom, Graeme I Bell, John Blangero, Ravindranath Duggirala, E Shyong Tai, Gilean McVean, Craig L Hanis, James G Wilson, Mark Seielstad, Timothy M Frayling, James B Meigs, Nancy J Cox, Rob Sladek, Eric S Lander, Stacey Gabriel, Karen L Mohlke, Thomas Meitinger, Leif Groop, Goncalo Abecasis, Laura J Scott, Andrew P Morris, Hyun Min Kang, David Altshuler, Noël P Burtt, Jose C Florez, Michael Boehnke, Mark I McCarthy

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Resumé

To investigate the genetic basis of type 2 diabetes (T2D) to high resolution, the GoT2D and T2D-GENES consortia catalogued variation from whole-genome sequencing of 2,657 European individuals and exome sequencing of 12,940 individuals of multiple ancestries. Over 27M SNPs, indels, and structural variants were identified, including 99% of low-frequency (minor allele frequency [MAF] 0.1-5%) non-coding variants in the whole-genome sequenced individuals and 99.7% of low-frequency coding variants in the whole-exome sequenced individuals. Each variant was tested for association with T2D in the sequenced individuals, and, to increase power, most were tested in larger numbers of individuals (>80% of low-frequency coding variants in ~82 K Europeans via the exome chip, and ~90% of low-frequency non-coding variants in ~44 K Europeans via genotype imputation). The variants, genotypes, and association statistics from these analyses provide the largest reference to date of human genetic information relevant to T2D, for use in activities such as T2D-focused genotype imputation, functional characterization of variants or genes, and other novel analyses to detect associations between sequence variation and T2D.

OriginalsprogEngelsk
Artikelnummer170179
TidsskriftScientific Data
Vol/bind4
Antal sider20
ISSN2052-4463
DOI
StatusUdgivet - 2017

Fingeraftryk

Diabetes
Medical problems
chronic illness
statistics
Statistics
Low Frequency
Genotype
Genes
Imputation
Sequencing
coding
Genome
Coding
Type 2 diabetes
Minor
Chip
High Resolution
Gene

Citer dette

Jason, F., Fuchsberger, C., Mahajan, A., Teslovich, T. M., Agarwala, V., Gaulton, K. J., ... McCarthy, M. I. (2017). Sequence data and association statistics from 12,940 type 2 diabetes cases and controls. Scientific Data, 4, [170179]. https://doi.org/10.1038/sdata.2017.179
Jason, Flannick ; Fuchsberger, Christian ; Mahajan, Anubha ; Teslovich, Tanya M ; Agarwala, Vineeta ; Gaulton, Kyle J ; Caulkins, Lizz ; Koesterer, Ryan ; Ma, Clement ; Moutsianas, Loukas ; McCarthy, Davis J ; Rivas, Manuel A ; Perry, John R B ; Sim, Xueling ; Blackwell, Thomas W ; Robertson, Neil R ; Rayner, N William ; Cingolani, Pablo ; Locke, Adam E ; Tajes, Juan Fernandez ; Highland, Heather M ; Dupuis, Josee ; Chines, Peter S ; Lindgren, Cecilia M ; Hartl, Christopher ; Jackson, Anne U ; Chen, Han ; Huyghe, Jeroen R ; van de Bunt, Martijn ; Pearson, Richard D ; Kumar, Ashish ; Müller-Nurasyid, Martina ; Grarup, Niels ; Stringham, Heather M ; Gamazon, Eric R ; Lee, Jaehoon ; Chen, Yuhui ; Scott, Robert A ; Below, Jennifer E ; Chen, Peng ; Huang, Jinyan ; Go, Min Jin ; Stitzel, Michael L ; Pasko, Dorota ; Parker, Stephen C J ; Varga, Tibor V ; Green, Todd ; Beer, Nicola L ; Day-Williams, Aaron G ; Ferreira, Teresa ; Fingerlin, Tasha ; Horikoshi, Momoko ; Hu, Cheng ; Huh, Iksoo ; Ikram, Mohammad Kamran ; Kim, Bong-Jo ; Kim, Yongkang ; Kim, Young Jin ; Kwon, Min-Seok ; Lee, Juyoung ; Lee, Selyeong ; Lin, Keng-Han ; Maxwell, Taylor J ; Nagai, Yoshihiko ; Wang, Xu ; Welch, Ryan P ; Yoon, Joon ; Zhang, Weihua ; Barzilai, Nir ; Voight, Benjamin F ; Han, Bok-Ghee ; Jenkinson, Christopher P ; Kuulasmaa, Teemu ; Kuusisto, Johanna ; Manning, Alisa ; Ng, Maggie C Y ; Palmer, Nicholette D ; Balkau, Beverley ; Stančáková, Alena ; Abboud, Hanna E ; Boeing, Heiner ; Giedraitis, Vilmantas ; Prabhakaran, Dorairaj ; Gottesman, Omri ; Scott, James ; Carey, Jason ; Kwan, Phoenix ; Grant, George ; Smith, Joshua D ; Neale, Benjamin M ; Purcell, Shaun ; Butterworth, Adam S ; Howson, Joanna M M ; Lee, Heung Man ; Lu, Yingchang ; Kwak, Soo-Heon ; Zhao, Wei ; Danesh, John ; Lam, Vincent K L ; Park, Kyong Soo ; Saleheen, Danish ; So, Wing Yee ; Tam, Claudia H T ; Afzal, Uzma ; Aguilar, David ; Arya, Rector ; Aung, Tin ; Chan, Edmund ; Navarro, Carmen ; Cheng, Ching-Yu ; Palli, Domenico ; Correa, Adolfo ; Curran, Joanne E ; Rybin, Dennis ; Farook, Vidya S ; Fowler, Sharon P ; Freedman, Barry I ; Griswold, Michael ; Hale, Daniel Esten ; Hicks, Pamela J ; Khor, Chiea-Chuen ; Kumar, Satish ; Lehne, Benjamin ; Thuillier, Dorothée ; Lim, Wei Yen ; Liu, Jianjun ; Loh, Marie ; Musani, Solomon K ; Puppala, Sobha ; Scott, William R ; Yengo, Loïc ; Tan, Sian-Tsung ; Taylor, Herman A ; Thameem, Farook ; Wilson, Gregory ; Wong, Tien Yin ; Njølstad, Pål Rasmus ; Levy, Jonathan C ; Mangino, Massimo ; Bonnycastle, Lori L ; Schwarzmayr, Thomas ; Fadista, João ; Surdulescu, Gabriela L ; Herder, Christian ; Groves, Christopher J ; Wieland, Thomas ; Bork-Jensen, Jette ; Brandslund, Ivan ; Christensen, Cramer ; Koistinen, Heikki A ; Doney, Alex S F ; Kinnunen, Leena ; Esko, Tõnu ; Farmer, Andrew J ; Hakaste, Liisa ; Hodgkiss, Dylan ; Kravic, Jasmina ; Lyssenko, Valeri ; Hollensted, Mette ; Jørgensen, Marit E ; Jørgensen, Torben ; Ladenvall, Claes ; Justesen, Johanne Marie ; Käräjämäki, Annemari ; Kriebel, Jennifer ; Rathmann, Wolfgang ; Lannfelt, Lars ; Lauritzen, Torsten ; Narisu, Narisu ; Linneberg, Allan ; Melander, Olle ; Milani, Lili ; Neville, Matt ; Orho-Melander, Marju ; Qi, Lu ; Qi, Qibin ; Roden, Michael ; Rolandsson, Olov ; Swift, Amy ; Rosengren, Anders H ; Stirrups, Kathleen ; Wood, Andrew R ; Mihailov, Evelin ; Blancher, Christine ; Carneiro, Mauricio O ; Maguire, Jared ; Poplin, Ryan ; Shakir, Khalid ; Fennell, Timothy ; DePristo, Mark ; de Angelis, Martin Hrabé ; Deloukas, Panos ; Gjesing, Anette P ; Jun, Goo ; Nilsson, Peter ; Murphy, Jacquelyn ; Onofrio, Robert ; Thorand, Barbara ; Hansen, Torben ; Meisinger, Christa ; Hu, Frank B ; Isomaa, Bo ; Karpe, Fredrik ; Liang, Liming ; Peters, Annette ; Huth, Cornelia ; O'Rahilly, Stephen P ; Palmer, Colin N A ; Pedersen, Oluf ; Rauramaa, Rainer ; Tuomilehto, Jaakko ; Salomaa, Veikko ; Watanabe, Richard M ; Syvänen, Ann-Christine ; Bergman, Richard N ; Bharadwaj, Dwaipayan ; Bottinger, Erwin P ; Cho, Yoon Shin ; Chandak, Giriraj R ; Chan, Juliana Cn ; Chia, Kee Seng ; Daly, Mark J ; Ebrahim, Shah B ; Langenberg, Claudia ; Elliott, Paul ; Jablonski, Kathleen A ; Lehman, Donna M ; Jia, Weiping ; Ma, Ronald C W ; Pollin, Toni I ; Sandhu, Manjinder ; Tandon, Nikhil ; Froguel, Philippe ; Barroso, Inês ; Teo, Yik Ying ; Zeggini, Eleftheria ; Loos, Ruth J F ; Small, Kerrin S ; Ried, Janina S ; DeFronzo, Ralph A ; Grallert, Harald ; Glaser, Benjamin ; Metspalu, Andres ; Wareham, Nicholas J ; Walker, Mark ; Banks, Eric ; Gieger, Christian ; Ingelsson, Erik ; Im, Hae Kyung ; Illig, Thomas ; Franks, Paul W ; Buck, Gemma ; Trakalo, Joseph ; Buck, David ; Prokopenko, Inga ; Mägi, Reedik ; Lind, Lars ; Farjoun, Yossi ; Owen, Katharine R ; Gloyn, Anna L ; Strauch, Konstantin ; Tuomi, Tiinamaija ; Kooner, Jaspal Singh ; Lee, Jong-Young ; Park, Taesung ; Donnelly, Peter ; Morris, Andrew D ; Hattersley, Andrew T ; Bowden, Donald W ; Collins, Francis S ; Atzmon, Gil ; Chambers, John C ; Spector, Timothy D ; Laakso, Markku ; Strom, Tim M ; Bell, Graeme I ; Blangero, John ; Duggirala, Ravindranath ; Tai, E Shyong ; McVean, Gilean ; Hanis, Craig L ; Wilson, James G ; Seielstad, Mark ; Frayling, Timothy M ; Meigs, James B ; Cox, Nancy J ; Sladek, Rob ; Lander, Eric S ; Gabriel, Stacey ; Mohlke, Karen L ; Meitinger, Thomas ; Groop, Leif ; Abecasis, Goncalo ; Scott, Laura J ; Morris, Andrew P ; Kang, Hyun Min ; Altshuler, David ; Burtt, Noël P ; Florez, Jose C ; Boehnke, Michael ; McCarthy, Mark I. / Sequence data and association statistics from 12,940 type 2 diabetes cases and controls. I: Scientific Data. 2017 ; Bind 4.
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abstract = "To investigate the genetic basis of type 2 diabetes (T2D) to high resolution, the GoT2D and T2D-GENES consortia catalogued variation from whole-genome sequencing of 2,657 European individuals and exome sequencing of 12,940 individuals of multiple ancestries. Over 27M SNPs, indels, and structural variants were identified, including 99{\%} of low-frequency (minor allele frequency [MAF] 0.1-5{\%}) non-coding variants in the whole-genome sequenced individuals and 99.7{\%} of low-frequency coding variants in the whole-exome sequenced individuals. Each variant was tested for association with T2D in the sequenced individuals, and, to increase power, most were tested in larger numbers of individuals (>80{\%} of low-frequency coding variants in ~82 K Europeans via the exome chip, and ~90{\%} of low-frequency non-coding variants in ~44 K Europeans via genotype imputation). The variants, genotypes, and association statistics from these analyses provide the largest reference to date of human genetic information relevant to T2D, for use in activities such as T2D-focused genotype imputation, functional characterization of variants or genes, and other novel analyses to detect associations between sequence variation and T2D.",
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Zhao and John Danesh and Lam, {Vincent K L} and Park, {Kyong Soo} and Danish Saleheen and So, {Wing Yee} and Tam, {Claudia H T} and Uzma Afzal and David Aguilar and Rector Arya and Tin Aung and Edmund Chan and Carmen Navarro and Ching-Yu Cheng and Domenico Palli and Adolfo Correa and Curran, {Joanne E} and Dennis Rybin and Farook, {Vidya S} and Fowler, {Sharon P} and Freedman, {Barry I} and Michael Griswold and Hale, {Daniel Esten} and Hicks, {Pamela J} and Chiea-Chuen Khor and Satish Kumar and Benjamin Lehne and Doroth{\'e}e Thuillier and Lim, {Wei Yen} and Jianjun Liu and Marie Loh and Musani, {Solomon K} and Sobha Puppala and Scott, {William R} and Lo{\"i}c Yengo and Sian-Tsung Tan and Taylor, {Herman A} and Farook Thameem and Gregory Wilson and Wong, {Tien Yin} and Nj{\o}lstad, {P{\aa}l Rasmus} and Levy, {Jonathan C} and Massimo Mangino and Bonnycastle, {Lori L} and Thomas Schwarzmayr and Jo{\~a}o Fadista and Surdulescu, {Gabriela L} and Christian Herder and Groves, {Christopher J} and Thomas Wieland and Jette Bork-Jensen and Ivan Brandslund and Cramer Christensen and Koistinen, {Heikki A} and Doney, {Alex S F} and Leena Kinnunen and T{\~o}nu Esko and Farmer, {Andrew J} and Liisa Hakaste and Dylan Hodgkiss and Jasmina Kravic and Valeri Lyssenko and Mette Hollensted and J{\o}rgensen, {Marit E} and Torben J{\o}rgensen and Claes Ladenvall and Justesen, {Johanne Marie} and Annemari K{\"a}r{\"a}j{\"a}m{\"a}ki and Jennifer Kriebel and Wolfgang Rathmann and Lars Lannfelt and Torsten Lauritzen and Narisu Narisu and Allan Linneberg and Olle Melander and Lili Milani and Matt Neville and Marju Orho-Melander and Lu Qi and Qibin Qi and Michael Roden and Olov Rolandsson and Amy Swift and Rosengren, {Anders H} and Kathleen Stirrups and Wood, {Andrew R} and Evelin Mihailov and Christine Blancher and Carneiro, {Mauricio O} and Jared Maguire and Ryan Poplin and Khalid Shakir and Timothy Fennell and Mark DePristo and {de Angelis}, {Martin Hrab{\'e}} and Panos Deloukas and Gjesing, {Anette P} and Goo Jun and Peter Nilsson and Jacquelyn Murphy and Robert Onofrio and Barbara Thorand and Torben Hansen and Christa Meisinger and Hu, {Frank B} and Bo Isomaa and Fredrik Karpe and Liming Liang and Annette Peters and Cornelia Huth and O'Rahilly, {Stephen P} and Palmer, {Colin N A} and Oluf Pedersen and Rainer Rauramaa and Jaakko Tuomilehto and Veikko Salomaa and Watanabe, {Richard M} and Ann-Christine Syv{\"a}nen and Bergman, {Richard N} and Dwaipayan Bharadwaj and Bottinger, {Erwin P} and Cho, {Yoon Shin} and Chandak, {Giriraj R} and Chan, {Juliana Cn} and Chia, {Kee Seng} and Daly, {Mark J} and Ebrahim, {Shah B} and Claudia Langenberg and Paul Elliott and Jablonski, {Kathleen A} and Lehman, {Donna M} and Weiping Jia and Ma, {Ronald C W} and Pollin, {Toni I} and Manjinder Sandhu and Nikhil Tandon and Philippe Froguel and In{\^e}s Barroso and Teo, {Yik Ying} and Eleftheria Zeggini and Loos, {Ruth J F} and Small, {Kerrin S} and Ried, {Janina S} and DeFronzo, {Ralph A} and Harald Grallert and Benjamin Glaser and Andres Metspalu and Wareham, {Nicholas J} and Mark Walker and Eric Banks and Christian Gieger and Erik Ingelsson and Im, {Hae Kyung} and Thomas Illig and Franks, {Paul W} and Gemma Buck and Joseph Trakalo and David Buck and Inga Prokopenko and Reedik M{\"a}gi and Lars Lind and Yossi Farjoun and Owen, {Katharine R} and Gloyn, {Anna L} and Konstantin Strauch and Tiinamaija Tuomi and Kooner, {Jaspal Singh} and Jong-Young Lee and Taesung Park and Peter Donnelly and Morris, {Andrew D} and Hattersley, {Andrew T} and Bowden, {Donald W} and Collins, {Francis S} and Gil Atzmon and Chambers, {John C} and Spector, {Timothy D} and Markku Laakso and Strom, {Tim M} and Bell, {Graeme I} and John Blangero and Ravindranath Duggirala and Tai, {E Shyong} and Gilean McVean and Hanis, {Craig L} and Wilson, {James G} and Mark Seielstad and Frayling, {Timothy M} and Meigs, {James B} and Cox, {Nancy J} and Rob Sladek and Lander, {Eric S} and Stacey Gabriel and Mohlke, {Karen L} and Thomas Meitinger and Leif Groop and Goncalo Abecasis and Scott, {Laura J} and Morris, {Andrew P} and Kang, {Hyun Min} and David Altshuler and Burtt, {No{\"e}l P} and Florez, {Jose C} and Michael Boehnke and McCarthy, {Mark I}",
year = "2017",
doi = "10.1038/sdata.2017.179",
language = "English",
volume = "4",
journal = "Scientific Data",
issn = "2052-4463",
publisher = "Nature Publishing Group",

}

Jason, F, Fuchsberger, C, Mahajan, A, Teslovich, TM, Agarwala, V, Gaulton, KJ, Caulkins, L, Koesterer, R, Ma, C, Moutsianas, L, McCarthy, DJ, Rivas, MA, Perry, JRB, Sim, X, Blackwell, TW, Robertson, NR, Rayner, NW, Cingolani, P, Locke, AE, Tajes, JF, Highland, HM, Dupuis, J, Chines, PS, Lindgren, CM, Hartl, C, Jackson, AU, Chen, H, Huyghe, JR, van de Bunt, M, Pearson, RD, Kumar, A, Müller-Nurasyid, M, Grarup, N, Stringham, HM, Gamazon, ER, Lee, J, Chen, Y, Scott, RA, Below, JE, Chen, P, Huang, J, Go, MJ, Stitzel, ML, Pasko, D, Parker, SCJ, Varga, TV, Green, T, Beer, NL, Day-Williams, AG, Ferreira, T, Fingerlin, T, Horikoshi, M, Hu, C, Huh, I, Ikram, MK, Kim, B-J, Kim, Y, Kim, YJ, Kwon, M-S, Lee, J, Lee, S, Lin, K-H, Maxwell, TJ, Nagai, Y, Wang, X, Welch, RP, Yoon, J, Zhang, W, Barzilai, N, Voight, BF, Han, B-G, Jenkinson, CP, Kuulasmaa, T, Kuusisto, J, Manning, A, Ng, MCY, Palmer, ND, Balkau, B, Stančáková, A, Abboud, HE, Boeing, H, Giedraitis, V, Prabhakaran, D, Gottesman, O, Scott, J, Carey, J, Kwan, P, Grant, G, Smith, JD, Neale, BM, Purcell, S, Butterworth, AS, Howson, JMM, Lee, HM, Lu, Y, Kwak, S-H, Zhao, W, Danesh, J, Lam, VKL, Park, KS, Saleheen, D, So, WY, Tam, CHT, Afzal, U, Aguilar, D, Arya, R, Aung, T, Chan, E, Navarro, C, Cheng, C-Y, Palli, D, Correa, A, Curran, JE, Rybin, D, Farook, VS, Fowler, SP, Freedman, BI, Griswold, M, Hale, DE, Hicks, PJ, Khor, C-C, Kumar, S, Lehne, B, Thuillier, D, Lim, WY, Liu, J, Loh, M, Musani, SK, Puppala, S, Scott, WR, Yengo, L, Tan, S-T, Taylor, HA, Thameem, F, Wilson, G, Wong, TY, Njølstad, PR, Levy, JC, Mangino, M, Bonnycastle, LL, Schwarzmayr, T, Fadista, J, Surdulescu, GL, Herder, C, Groves, CJ, Wieland, T, Bork-Jensen, J, Brandslund, I, Christensen, C, Koistinen, HA, Doney, ASF, Kinnunen, L, Esko, T, Farmer, AJ, Hakaste, L, Hodgkiss, D, Kravic, J, Lyssenko, V, Hollensted, M, Jørgensen, ME, Jørgensen, T, Ladenvall, C, Justesen, JM, Käräjämäki, A, Kriebel, J, Rathmann, W, Lannfelt, L, Lauritzen, T, Narisu, N, Linneberg, A, Melander, O, Milani, L, Neville, M, Orho-Melander, M, Qi, L, Qi, Q, Roden, M, Rolandsson, O, Swift, A, Rosengren, AH, Stirrups, K, Wood, AR, Mihailov, E, Blancher, C, Carneiro, MO, Maguire, J, Poplin, R, Shakir, K, Fennell, T, DePristo, M, de Angelis, MH, Deloukas, P, Gjesing, AP, Jun, G, Nilsson, P, Murphy, J, Onofrio, R, Thorand, B, Hansen, T, Meisinger, C, Hu, FB, Isomaa, B, Karpe, F, Liang, L, Peters, A, Huth, C, O'Rahilly, SP, Palmer, CNA, Pedersen, O, Rauramaa, R, Tuomilehto, J, Salomaa, V, Watanabe, RM, Syvänen, A-C, Bergman, RN, Bharadwaj, D, Bottinger, EP, Cho, YS, Chandak, GR, Chan, JC, Chia, KS, Daly, MJ, Ebrahim, SB, Langenberg, C, Elliott, P, Jablonski, KA, Lehman, DM, Jia, W, Ma, RCW, Pollin, TI, Sandhu, M, Tandon, N, Froguel, P, Barroso, I, Teo, YY, Zeggini, E, Loos, RJF, Small, KS, Ried, JS, DeFronzo, RA, Grallert, H, Glaser, B, Metspalu, A, Wareham, NJ, Walker, M, Banks, E, Gieger, C, Ingelsson, E, Im, HK, Illig, T, Franks, PW, Buck, G, Trakalo, J, Buck, D, Prokopenko, I, Mägi, R, Lind, L, Farjoun, Y, Owen, KR, Gloyn, AL, Strauch, K, Tuomi, T, Kooner, JS, Lee, J-Y, Park, T, Donnelly, P, Morris, AD, Hattersley, AT, Bowden, DW, Collins, FS, Atzmon, G, Chambers, JC, Spector, TD, Laakso, M, Strom, TM, Bell, GI, Blangero, J, Duggirala, R, Tai, ES, McVean, G, Hanis, CL, Wilson, JG, Seielstad, M, Frayling, TM, Meigs, JB, Cox, NJ, Sladek, R, Lander, ES, Gabriel, S, Mohlke, KL, Meitinger, T, Groop, L, Abecasis, G, Scott, LJ, Morris, AP, Kang, HM, Altshuler, D, Burtt, NP, Florez, JC, Boehnke, M & McCarthy, MI 2017, 'Sequence data and association statistics from 12,940 type 2 diabetes cases and controls', Scientific Data, bind 4, 170179. https://doi.org/10.1038/sdata.2017.179

Sequence data and association statistics from 12,940 type 2 diabetes cases and controls. / Jason, Flannick; Fuchsberger, Christian; Mahajan, Anubha; Teslovich, Tanya M; Agarwala, Vineeta; Gaulton, Kyle J; Caulkins, Lizz; Koesterer, Ryan; Ma, Clement; Moutsianas, Loukas; McCarthy, Davis J; Rivas, Manuel A; Perry, John R B; Sim, Xueling; Blackwell, Thomas W; Robertson, Neil R; Rayner, N William; Cingolani, Pablo; Locke, Adam E; Tajes, Juan Fernandez; Highland, Heather M; Dupuis, Josee; Chines, Peter S; Lindgren, Cecilia M; Hartl, Christopher; Jackson, Anne U; Chen, Han; Huyghe, Jeroen R; van de Bunt, Martijn; Pearson, Richard D; Kumar, Ashish; Müller-Nurasyid, Martina; Grarup, Niels; Stringham, Heather M; Gamazon, Eric R; Lee, Jaehoon; Chen, Yuhui; Scott, Robert A; Below, Jennifer E; Chen, Peng; Huang, Jinyan; Go, Min Jin; Stitzel, Michael L; Pasko, Dorota; Parker, Stephen C J; Varga, Tibor V; Green, Todd; Beer, Nicola L; Day-Williams, Aaron G; Ferreira, Teresa; Fingerlin, Tasha; Horikoshi, Momoko; Hu, Cheng; Huh, Iksoo; Ikram, Mohammad Kamran; Kim, Bong-Jo; Kim, Yongkang; Kim, Young Jin; Kwon, Min-Seok; Lee, Juyoung; Lee, Selyeong; Lin, Keng-Han; Maxwell, Taylor J; Nagai, Yoshihiko; Wang, Xu; Welch, Ryan P; Yoon, Joon; Zhang, Weihua; Barzilai, Nir; Voight, Benjamin F; Han, Bok-Ghee; Jenkinson, Christopher P; Kuulasmaa, Teemu; Kuusisto, Johanna; Manning, Alisa; Ng, Maggie C Y; Palmer, Nicholette D; Balkau, Beverley; Stančáková, Alena; Abboud, Hanna E; Boeing, Heiner; Giedraitis, Vilmantas; Prabhakaran, Dorairaj; Gottesman, Omri; Scott, James; Carey, Jason; Kwan, Phoenix; Grant, George; Smith, Joshua D; Neale, Benjamin M; Purcell, Shaun; Butterworth, Adam S; Howson, Joanna M M; Lee, Heung Man; Lu, Yingchang; Kwak, Soo-Heon; Zhao, Wei; Danesh, John; Lam, Vincent K L; Park, Kyong Soo; Saleheen, Danish; So, Wing Yee; Tam, Claudia H T; Afzal, Uzma; Aguilar, David; Arya, Rector; Aung, Tin; Chan, Edmund; Navarro, Carmen; Cheng, Ching-Yu; Palli, Domenico; Correa, Adolfo; Curran, Joanne E; Rybin, Dennis; Farook, Vidya S; Fowler, Sharon P; Freedman, Barry I; Griswold, Michael; Hale, Daniel Esten; Hicks, Pamela J; Khor, Chiea-Chuen; Kumar, Satish; Lehne, Benjamin; Thuillier, Dorothée; Lim, Wei Yen; Liu, Jianjun; Loh, Marie; Musani, Solomon K; Puppala, Sobha; Scott, William R; Yengo, Loïc; Tan, Sian-Tsung; Taylor, Herman A; Thameem, Farook; Wilson, Gregory; Wong, Tien Yin; Njølstad, Pål Rasmus; Levy, Jonathan C; Mangino, Massimo; Bonnycastle, Lori L; Schwarzmayr, Thomas; Fadista, João; Surdulescu, Gabriela L; Herder, Christian; Groves, Christopher J; Wieland, Thomas; Bork-Jensen, Jette; Brandslund, Ivan; Christensen, Cramer; Koistinen, Heikki A; Doney, Alex S F; Kinnunen, Leena; Esko, Tõnu; Farmer, Andrew J; Hakaste, Liisa; Hodgkiss, Dylan; Kravic, Jasmina; Lyssenko, Valeri; Hollensted, Mette; Jørgensen, Marit E; Jørgensen, Torben; Ladenvall, Claes; Justesen, Johanne Marie; Käräjämäki, Annemari; Kriebel, Jennifer; Rathmann, Wolfgang; Lannfelt, Lars; Lauritzen, Torsten; Narisu, Narisu; Linneberg, Allan; Melander, Olle; Milani, Lili; Neville, Matt; Orho-Melander, Marju; Qi, Lu; Qi, Qibin; Roden, Michael; Rolandsson, Olov; Swift, Amy; Rosengren, Anders H; Stirrups, Kathleen; Wood, Andrew R; Mihailov, Evelin; Blancher, Christine; Carneiro, Mauricio O; Maguire, Jared; Poplin, Ryan; Shakir, Khalid; Fennell, Timothy; DePristo, Mark; de Angelis, Martin Hrabé; Deloukas, Panos; Gjesing, Anette P; Jun, Goo; Nilsson, Peter; Murphy, Jacquelyn; Onofrio, Robert; Thorand, Barbara; Hansen, Torben; Meisinger, Christa; Hu, Frank B; Isomaa, Bo; Karpe, Fredrik; Liang, Liming; Peters, Annette; Huth, Cornelia; O'Rahilly, Stephen P; Palmer, Colin N A; Pedersen, Oluf; Rauramaa, Rainer; Tuomilehto, Jaakko; Salomaa, Veikko; Watanabe, Richard M; Syvänen, Ann-Christine; Bergman, Richard N; Bharadwaj, Dwaipayan; Bottinger, Erwin P; Cho, Yoon Shin; Chandak, Giriraj R; Chan, Juliana Cn; Chia, Kee Seng; Daly, Mark J; Ebrahim, Shah B; Langenberg, Claudia; Elliott, Paul; Jablonski, Kathleen A; Lehman, Donna M; Jia, Weiping; Ma, Ronald C W; Pollin, Toni I; Sandhu, Manjinder; Tandon, Nikhil; Froguel, Philippe; Barroso, Inês; Teo, Yik Ying; Zeggini, Eleftheria; Loos, Ruth J F; Small, Kerrin S; Ried, Janina S; DeFronzo, Ralph A; Grallert, Harald; Glaser, Benjamin; Metspalu, Andres; Wareham, Nicholas J; Walker, Mark; Banks, Eric; Gieger, Christian; Ingelsson, Erik; Im, Hae Kyung; Illig, Thomas; Franks, Paul W; Buck, Gemma; Trakalo, Joseph; Buck, David; Prokopenko, Inga; Mägi, Reedik; Lind, Lars; Farjoun, Yossi; Owen, Katharine R; Gloyn, Anna L; Strauch, Konstantin; Tuomi, Tiinamaija; Kooner, Jaspal Singh; Lee, Jong-Young; Park, Taesung; Donnelly, Peter; Morris, Andrew D; Hattersley, Andrew T; Bowden, Donald W; Collins, Francis S; Atzmon, Gil; Chambers, John C; Spector, Timothy D; Laakso, Markku; Strom, Tim M; Bell, Graeme I; Blangero, John; Duggirala, Ravindranath; Tai, E Shyong; McVean, Gilean; Hanis, Craig L; Wilson, James G; Seielstad, Mark; Frayling, Timothy M; Meigs, James B; Cox, Nancy J; Sladek, Rob; Lander, Eric S; Gabriel, Stacey; Mohlke, Karen L; Meitinger, Thomas; Groop, Leif; Abecasis, Goncalo; Scott, Laura J; Morris, Andrew P; Kang, Hyun Min; Altshuler, David; Burtt, Noël P; Florez, Jose C; Boehnke, Michael; McCarthy, Mark I.

I: Scientific Data, Bind 4, 170179, 2017.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

AU - Jason, Flannick

AU - Fuchsberger, Christian

AU - Mahajan, Anubha

AU - Teslovich, Tanya M

AU - Agarwala, Vineeta

AU - Gaulton, Kyle J

AU - Caulkins, Lizz

AU - Koesterer, Ryan

AU - Ma, Clement

AU - Moutsianas, Loukas

AU - McCarthy, Davis J

AU - Rivas, Manuel A

AU - Perry, John R B

AU - Sim, Xueling

AU - Blackwell, Thomas W

AU - Robertson, Neil R

AU - Rayner, N William

AU - Cingolani, Pablo

AU - Locke, Adam E

AU - Tajes, Juan Fernandez

AU - Highland, Heather M

AU - Dupuis, Josee

AU - Chines, Peter S

AU - Lindgren, Cecilia M

AU - Hartl, Christopher

AU - Jackson, Anne U

AU - Chen, Han

AU - Huyghe, Jeroen R

AU - van de Bunt, Martijn

AU - Pearson, Richard D

AU - Kumar, Ashish

AU - Müller-Nurasyid, Martina

AU - Grarup, Niels

AU - Stringham, Heather M

AU - Gamazon, Eric R

AU - Lee, Jaehoon

AU - Chen, Yuhui

AU - Scott, Robert A

AU - Below, Jennifer E

AU - Chen, Peng

AU - Huang, Jinyan

AU - Go, Min Jin

AU - Stitzel, Michael L

AU - Pasko, Dorota

AU - Parker, Stephen C J

AU - Varga, Tibor V

AU - Green, Todd

AU - Beer, Nicola L

AU - Day-Williams, Aaron G

AU - Ferreira, Teresa

AU - Fingerlin, Tasha

AU - Horikoshi, Momoko

AU - Hu, Cheng

AU - Huh, Iksoo

AU - Ikram, Mohammad Kamran

AU - Kim, Bong-Jo

AU - Kim, Yongkang

AU - Kim, Young Jin

AU - Kwon, Min-Seok

AU - Lee, Juyoung

AU - Lee, Selyeong

AU - Lin, Keng-Han

AU - Maxwell, Taylor J

AU - Nagai, Yoshihiko

AU - Wang, Xu

AU - Welch, Ryan P

AU - Yoon, Joon

AU - Zhang, Weihua

AU - Barzilai, Nir

AU - Voight, Benjamin F

AU - Han, Bok-Ghee

AU - Jenkinson, Christopher P

AU - Kuulasmaa, Teemu

AU - Kuusisto, Johanna

AU - Manning, Alisa

AU - Ng, Maggie C Y

AU - Palmer, Nicholette D

AU - Balkau, Beverley

AU - Stančáková, Alena

AU - Abboud, Hanna E

AU - Boeing, Heiner

AU - Giedraitis, Vilmantas

AU - Prabhakaran, Dorairaj

AU - Gottesman, Omri

AU - Scott, James

AU - Carey, Jason

AU - Kwan, Phoenix

AU - Grant, George

AU - Smith, Joshua D

AU - Neale, Benjamin M

AU - Purcell, Shaun

AU - Butterworth, Adam S

AU - Howson, Joanna M M

AU - Lee, Heung Man

AU - Lu, Yingchang

AU - Kwak, Soo-Heon

AU - Zhao, Wei

AU - Danesh, John

AU - Lam, Vincent K L

AU - Park, Kyong Soo

AU - Saleheen, Danish

AU - So, Wing Yee

AU - Tam, Claudia H T

AU - Afzal, Uzma

AU - Aguilar, David

AU - Arya, Rector

AU - Aung, Tin

AU - Chan, Edmund

AU - Navarro, Carmen

AU - Cheng, Ching-Yu

AU - Palli, Domenico

AU - Correa, Adolfo

AU - Curran, Joanne E

AU - Rybin, Dennis

AU - Farook, Vidya S

AU - Fowler, Sharon P

AU - Freedman, Barry I

AU - Griswold, Michael

AU - Hale, Daniel Esten

AU - Hicks, Pamela J

AU - Khor, Chiea-Chuen

AU - Kumar, Satish

AU - Lehne, Benjamin

AU - Thuillier, Dorothée

AU - Lim, Wei Yen

AU - Liu, Jianjun

AU - Loh, Marie

AU - Musani, Solomon K

AU - Puppala, Sobha

AU - Scott, William R

AU - Yengo, Loïc

AU - Tan, Sian-Tsung

AU - Taylor, Herman A

AU - Thameem, Farook

AU - Wilson, Gregory

AU - Wong, Tien Yin

AU - Njølstad, Pål Rasmus

AU - Levy, Jonathan C

AU - Mangino, Massimo

AU - Bonnycastle, Lori L

AU - Schwarzmayr, Thomas

AU - Fadista, João

AU - Surdulescu, Gabriela L

AU - Herder, Christian

AU - Groves, Christopher J

AU - Wieland, Thomas

AU - Bork-Jensen, Jette

AU - Brandslund, Ivan

AU - Christensen, Cramer

AU - Koistinen, Heikki A

AU - Doney, Alex S F

AU - Kinnunen, Leena

AU - Esko, Tõnu

AU - Farmer, Andrew J

AU - Hakaste, Liisa

AU - Hodgkiss, Dylan

AU - Kravic, Jasmina

AU - Lyssenko, Valeri

AU - Hollensted, Mette

AU - Jørgensen, Marit E

AU - Jørgensen, Torben

AU - Ladenvall, Claes

AU - Justesen, Johanne Marie

AU - Käräjämäki, Annemari

AU - Kriebel, Jennifer

AU - Rathmann, Wolfgang

AU - Lannfelt, Lars

AU - Lauritzen, Torsten

AU - Narisu, Narisu

AU - Linneberg, Allan

AU - Melander, Olle

AU - Milani, Lili

AU - Neville, Matt

AU - Orho-Melander, Marju

AU - Qi, Lu

AU - Qi, Qibin

AU - Roden, Michael

AU - Rolandsson, Olov

AU - Swift, Amy

AU - Rosengren, Anders H

AU - Stirrups, Kathleen

AU - Wood, Andrew R

AU - Mihailov, Evelin

AU - Blancher, Christine

AU - Carneiro, Mauricio O

AU - Maguire, Jared

AU - Poplin, Ryan

AU - Shakir, Khalid

AU - Fennell, Timothy

AU - DePristo, Mark

AU - de Angelis, Martin Hrabé

AU - Deloukas, Panos

AU - Gjesing, Anette P

AU - Jun, Goo

AU - Nilsson, Peter

AU - Murphy, Jacquelyn

AU - Onofrio, Robert

AU - Thorand, Barbara

AU - Hansen, Torben

AU - Meisinger, Christa

AU - Hu, Frank B

AU - Isomaa, Bo

AU - Karpe, Fredrik

AU - Liang, Liming

AU - Peters, Annette

AU - Huth, Cornelia

AU - O'Rahilly, Stephen P

AU - Palmer, Colin N A

AU - Pedersen, Oluf

AU - Rauramaa, Rainer

AU - Tuomilehto, Jaakko

AU - Salomaa, Veikko

AU - Watanabe, Richard M

AU - Syvänen, Ann-Christine

AU - Bergman, Richard N

AU - Bharadwaj, Dwaipayan

AU - Bottinger, Erwin P

AU - Cho, Yoon Shin

AU - Chandak, Giriraj R

AU - Chan, Juliana Cn

AU - Chia, Kee Seng

AU - Daly, Mark J

AU - Ebrahim, Shah B

AU - Langenberg, Claudia

AU - Elliott, Paul

AU - Jablonski, Kathleen A

AU - Lehman, Donna M

AU - Jia, Weiping

AU - Ma, Ronald C W

AU - Pollin, Toni I

AU - Sandhu, Manjinder

AU - Tandon, Nikhil

AU - Froguel, Philippe

AU - Barroso, Inês

AU - Teo, Yik Ying

AU - Zeggini, Eleftheria

AU - Loos, Ruth J F

AU - Small, Kerrin S

AU - Ried, Janina S

AU - DeFronzo, Ralph A

AU - Grallert, Harald

AU - Glaser, Benjamin

AU - Metspalu, Andres

AU - Wareham, Nicholas J

AU - Walker, Mark

AU - Banks, Eric

AU - Gieger, Christian

AU - Ingelsson, Erik

AU - Im, Hae Kyung

AU - Illig, Thomas

AU - Franks, Paul W

AU - Buck, Gemma

AU - Trakalo, Joseph

AU - Buck, David

AU - Prokopenko, Inga

AU - Mägi, Reedik

AU - Lind, Lars

AU - Farjoun, Yossi

AU - Owen, Katharine R

AU - Gloyn, Anna L

AU - Strauch, Konstantin

AU - Tuomi, Tiinamaija

AU - Kooner, Jaspal Singh

AU - Lee, Jong-Young

AU - Park, Taesung

AU - Donnelly, Peter

AU - Morris, Andrew D

AU - Hattersley, Andrew T

AU - Bowden, Donald W

AU - Collins, Francis S

AU - Atzmon, Gil

AU - Chambers, John C

AU - Spector, Timothy D

AU - Laakso, Markku

AU - Strom, Tim M

AU - Bell, Graeme I

AU - Blangero, John

AU - Duggirala, Ravindranath

AU - Tai, E Shyong

AU - McVean, Gilean

AU - Hanis, Craig L

AU - Wilson, James G

AU - Seielstad, Mark

AU - Frayling, Timothy M

AU - Meigs, James B

AU - Cox, Nancy J

AU - Sladek, Rob

AU - Lander, Eric S

AU - Gabriel, Stacey

AU - Mohlke, Karen L

AU - Meitinger, Thomas

AU - Groop, Leif

AU - Abecasis, Goncalo

AU - Scott, Laura J

AU - Morris, Andrew P

AU - Kang, Hyun Min

AU - Altshuler, David

AU - Burtt, Noël P

AU - Florez, Jose C

AU - Boehnke, Michael

AU - McCarthy, Mark I

PY - 2017

Y1 - 2017

N2 - To investigate the genetic basis of type 2 diabetes (T2D) to high resolution, the GoT2D and T2D-GENES consortia catalogued variation from whole-genome sequencing of 2,657 European individuals and exome sequencing of 12,940 individuals of multiple ancestries. Over 27M SNPs, indels, and structural variants were identified, including 99% of low-frequency (minor allele frequency [MAF] 0.1-5%) non-coding variants in the whole-genome sequenced individuals and 99.7% of low-frequency coding variants in the whole-exome sequenced individuals. Each variant was tested for association with T2D in the sequenced individuals, and, to increase power, most were tested in larger numbers of individuals (>80% of low-frequency coding variants in ~82 K Europeans via the exome chip, and ~90% of low-frequency non-coding variants in ~44 K Europeans via genotype imputation). The variants, genotypes, and association statistics from these analyses provide the largest reference to date of human genetic information relevant to T2D, for use in activities such as T2D-focused genotype imputation, functional characterization of variants or genes, and other novel analyses to detect associations between sequence variation and T2D.

AB - To investigate the genetic basis of type 2 diabetes (T2D) to high resolution, the GoT2D and T2D-GENES consortia catalogued variation from whole-genome sequencing of 2,657 European individuals and exome sequencing of 12,940 individuals of multiple ancestries. Over 27M SNPs, indels, and structural variants were identified, including 99% of low-frequency (minor allele frequency [MAF] 0.1-5%) non-coding variants in the whole-genome sequenced individuals and 99.7% of low-frequency coding variants in the whole-exome sequenced individuals. Each variant was tested for association with T2D in the sequenced individuals, and, to increase power, most were tested in larger numbers of individuals (>80% of low-frequency coding variants in ~82 K Europeans via the exome chip, and ~90% of low-frequency non-coding variants in ~44 K Europeans via genotype imputation). The variants, genotypes, and association statistics from these analyses provide the largest reference to date of human genetic information relevant to T2D, for use in activities such as T2D-focused genotype imputation, functional characterization of variants or genes, and other novel analyses to detect associations between sequence variation and T2D.

KW - Journal Article

UR - https://doi.org/10.1038/sdata.2018.2

U2 - 10.1038/sdata.2017.179

DO - 10.1038/sdata.2017.179

M3 - Journal article

VL - 4

JO - Scientific Data

JF - Scientific Data

SN - 2052-4463

M1 - 170179

ER -

Jason F, Fuchsberger C, Mahajan A, Teslovich TM, Agarwala V, Gaulton KJ et al. Sequence data and association statistics from 12,940 type 2 diabetes cases and controls. Scientific Data. 2017;4. 170179. https://doi.org/10.1038/sdata.2017.179