Sentinel lymph node biopsy in breast cancer--the Aarhus experience

M C Lauridsen, J P Garne, I Hessov, Flemming Brandt Sørensen, F Melsen, A Lernevall, P Christiansen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Eighty patients, with newly diagnosed unifocal breast cancer and with no axillary metastases verified by ultrasonography, underwent sentinel lymph node (SLN) and subsequent axillary lymph node dissection. To identify the SLN, we used a combination of Tc-99m labelled colloid (Albures) and blue dye (Patent Blue V) injected peritumorally. Lymphoscintigraphy was not performed. The SLN was successfully identified in 78 out of 80 patients (97.5%); 43 patients (54%) were found to have metastatic disease. In 33 patients (77%) the SLN was the only node involved. No false-negative nodes were found, defined as SLNs that tested negative but with higher nodes that tested positive. If SLN biopsy is accepted as a routine procedure and when the exact indications are defined, the method described probably could be offered to the majority of breast cancer patients.

OriginalsprogEngelsk
TidsskriftActa Oncologica
Vol/bind39
Udgave nummer3
Sider (fra-til)421-2
Antal sider2
ISSN0284-186X
StatusUdgivet - 2000

Fingeraftryk

Sentinel Lymph Node Biopsy
Lymphoscintigraphy
Ultrasonography
Coloring Agents

Citer dette

Lauridsen, M. C., Garne, J. P., Hessov, I., Sørensen, F. B., Melsen, F., Lernevall, A., & Christiansen, P. (2000). Sentinel lymph node biopsy in breast cancer--the Aarhus experience. Acta Oncologica, 39(3), 421-2.
Lauridsen, M C ; Garne, J P ; Hessov, I ; Sørensen, Flemming Brandt ; Melsen, F ; Lernevall, A ; Christiansen, P. / Sentinel lymph node biopsy in breast cancer--the Aarhus experience. I: Acta Oncologica. 2000 ; Bind 39, Nr. 3. s. 421-2.
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title = "Sentinel lymph node biopsy in breast cancer--the Aarhus experience",
abstract = "Eighty patients, with newly diagnosed unifocal breast cancer and with no axillary metastases verified by ultrasonography, underwent sentinel lymph node (SLN) and subsequent axillary lymph node dissection. To identify the SLN, we used a combination of Tc-99m labelled colloid (Albures) and blue dye (Patent Blue V) injected peritumorally. Lymphoscintigraphy was not performed. The SLN was successfully identified in 78 out of 80 patients (97.5{\%}); 43 patients (54{\%}) were found to have metastatic disease. In 33 patients (77{\%}) the SLN was the only node involved. No false-negative nodes were found, defined as SLNs that tested negative but with higher nodes that tested positive. If SLN biopsy is accepted as a routine procedure and when the exact indications are defined, the method described probably could be offered to the majority of breast cancer patients.",
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Lauridsen, MC, Garne, JP, Hessov, I, Sørensen, FB, Melsen, F, Lernevall, A & Christiansen, P 2000, 'Sentinel lymph node biopsy in breast cancer--the Aarhus experience', Acta Oncologica, bind 39, nr. 3, s. 421-2.

Sentinel lymph node biopsy in breast cancer--the Aarhus experience. / Lauridsen, M C; Garne, J P; Hessov, I; Sørensen, Flemming Brandt; Melsen, F; Lernevall, A; Christiansen, P.

I: Acta Oncologica, Bind 39, Nr. 3, 2000, s. 421-2.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Sentinel lymph node biopsy in breast cancer--the Aarhus experience

AU - Lauridsen, M C

AU - Garne, J P

AU - Hessov, I

AU - Sørensen, Flemming Brandt

AU - Melsen, F

AU - Lernevall, A

AU - Christiansen, P

PY - 2000

Y1 - 2000

N2 - Eighty patients, with newly diagnosed unifocal breast cancer and with no axillary metastases verified by ultrasonography, underwent sentinel lymph node (SLN) and subsequent axillary lymph node dissection. To identify the SLN, we used a combination of Tc-99m labelled colloid (Albures) and blue dye (Patent Blue V) injected peritumorally. Lymphoscintigraphy was not performed. The SLN was successfully identified in 78 out of 80 patients (97.5%); 43 patients (54%) were found to have metastatic disease. In 33 patients (77%) the SLN was the only node involved. No false-negative nodes were found, defined as SLNs that tested negative but with higher nodes that tested positive. If SLN biopsy is accepted as a routine procedure and when the exact indications are defined, the method described probably could be offered to the majority of breast cancer patients.

AB - Eighty patients, with newly diagnosed unifocal breast cancer and with no axillary metastases verified by ultrasonography, underwent sentinel lymph node (SLN) and subsequent axillary lymph node dissection. To identify the SLN, we used a combination of Tc-99m labelled colloid (Albures) and blue dye (Patent Blue V) injected peritumorally. Lymphoscintigraphy was not performed. The SLN was successfully identified in 78 out of 80 patients (97.5%); 43 patients (54%) were found to have metastatic disease. In 33 patients (77%) the SLN was the only node involved. No false-negative nodes were found, defined as SLNs that tested negative but with higher nodes that tested positive. If SLN biopsy is accepted as a routine procedure and when the exact indications are defined, the method described probably could be offered to the majority of breast cancer patients.

KW - Adult

KW - Axilla

KW - Biopsy

KW - Breast Neoplasms

KW - False Negative Reactions

KW - Female

KW - Humans

KW - Lymph Node Excision

KW - Lymph Nodes

KW - Lymphatic Metastasis

KW - Neoplasm Staging

M3 - Journal article

C2 - 10987240

VL - 39

SP - 421

EP - 422

JO - Acta Oncologica

JF - Acta Oncologica

SN - 0284-186X

IS - 3

ER -

Lauridsen MC, Garne JP, Hessov I, Sørensen FB, Melsen F, Lernevall A et al. Sentinel lymph node biopsy in breast cancer--the Aarhus experience. Acta Oncologica. 2000;39(3):421-2.