Sensory function and pain in a population of patients treated for breast cancer

O J Vilholm, S Cold, Lars Rasmussen, S H Sindrup

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Udgivelsesdato: 2009-Jul
OriginalsprogEngelsk
TidsskriftActa Anaesthesiologica Scandinavica
Vol/bind53
Udgave nummer6
Sider (fra-til)800-6
Antal sider6
ISSN0001-5172
DOI
StatusUdgivet - 1. jul. 2009

Fingeraftryk

Chronic Pain
Population
Hyperalgesia
Pain Threshold
Equipment and Supplies

Citer dette

@article{38c5fdb0a1d111de9743000ea68e967b,
title = "Sensory function and pain in a population of patients treated for breast cancer",
abstract = "BACKGROUND: Chronic pain is often reported after surgery for breast cancer. This study examined pain and sensory abnormalities in women following breast cancer surgery. METHODS: Sensory tests were carried out on the operated and contra-lateral side in 55 women with chronic pain after breast cancer treatment and in a reference group of 27 pain-free women, who had also undergone treatment for breast cancer. Testing included a numeric rating score of spontaneous pain, detection and pain threshold to thermal and dynamic mechanical stimuli and temporal summation to repetitive pinprick stimulation. The neuropathic pain symptom inventory was applied for participants with chronic pain. RESULTS: The mean age was 58.6 years for the pain patients and 60.6 years for the pain-free patients. Thermal thresholds were significantly higher on the operated side than on the contra-lateral side in both groups and side difference in warmth detection threshold was significantly higher in the pain group than in the pain-free group (mean 3.8 degrees C vs. 1.1 degrees C, P=0.01). The frequency of cold allodynia was higher in participants with pain than in pain-free participants (15/53 vs. 1/25, P=0.01), and the frequency of temporal summation evoked by repetitive pinprick was higher in participants with pain than in pain-free participants (23/53 vs. 2/25, P=0.0009). The frequency of dynamic mechanical allodynia did not differ significantly between the two groups. CONCLUSION: These findings suggest that chronic pain after surgery for breast cancer is associated with sensory hyperexcitability and is a neuropathic pain condition.",
keywords = "Breast Neoplasms, Chronic Disease, Cold Temperature, Female, Humans, Middle Aged, Pain Measurement, Pain Threshold, Pain, Postoperative, Peripheral Nervous System Diseases, Physical Stimulation, Sensation",
author = "Vilholm, {O J} and S Cold and Lars Rasmussen and Sindrup, {S H}",
year = "2009",
month = "7",
day = "1",
doi = "10.1111/j.1399-6576.2009.01938.x",
language = "English",
volume = "53",
pages = "800--6",
journal = "Acta Anaesthesiologica Scandinavica",
issn = "0001-5172",
publisher = "Wiley-Blackwell",
number = "6",

}

Sensory function and pain in a population of patients treated for breast cancer. / Vilholm, O J; Cold, S; Rasmussen, Lars; Sindrup, S H.

I: Acta Anaesthesiologica Scandinavica, Bind 53, Nr. 6, 01.07.2009, s. 800-6.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Sensory function and pain in a population of patients treated for breast cancer

AU - Vilholm, O J

AU - Cold, S

AU - Rasmussen, Lars

AU - Sindrup, S H

PY - 2009/7/1

Y1 - 2009/7/1

N2 - BACKGROUND: Chronic pain is often reported after surgery for breast cancer. This study examined pain and sensory abnormalities in women following breast cancer surgery. METHODS: Sensory tests were carried out on the operated and contra-lateral side in 55 women with chronic pain after breast cancer treatment and in a reference group of 27 pain-free women, who had also undergone treatment for breast cancer. Testing included a numeric rating score of spontaneous pain, detection and pain threshold to thermal and dynamic mechanical stimuli and temporal summation to repetitive pinprick stimulation. The neuropathic pain symptom inventory was applied for participants with chronic pain. RESULTS: The mean age was 58.6 years for the pain patients and 60.6 years for the pain-free patients. Thermal thresholds were significantly higher on the operated side than on the contra-lateral side in both groups and side difference in warmth detection threshold was significantly higher in the pain group than in the pain-free group (mean 3.8 degrees C vs. 1.1 degrees C, P=0.01). The frequency of cold allodynia was higher in participants with pain than in pain-free participants (15/53 vs. 1/25, P=0.01), and the frequency of temporal summation evoked by repetitive pinprick was higher in participants with pain than in pain-free participants (23/53 vs. 2/25, P=0.0009). The frequency of dynamic mechanical allodynia did not differ significantly between the two groups. CONCLUSION: These findings suggest that chronic pain after surgery for breast cancer is associated with sensory hyperexcitability and is a neuropathic pain condition.

AB - BACKGROUND: Chronic pain is often reported after surgery for breast cancer. This study examined pain and sensory abnormalities in women following breast cancer surgery. METHODS: Sensory tests were carried out on the operated and contra-lateral side in 55 women with chronic pain after breast cancer treatment and in a reference group of 27 pain-free women, who had also undergone treatment for breast cancer. Testing included a numeric rating score of spontaneous pain, detection and pain threshold to thermal and dynamic mechanical stimuli and temporal summation to repetitive pinprick stimulation. The neuropathic pain symptom inventory was applied for participants with chronic pain. RESULTS: The mean age was 58.6 years for the pain patients and 60.6 years for the pain-free patients. Thermal thresholds were significantly higher on the operated side than on the contra-lateral side in both groups and side difference in warmth detection threshold was significantly higher in the pain group than in the pain-free group (mean 3.8 degrees C vs. 1.1 degrees C, P=0.01). The frequency of cold allodynia was higher in participants with pain than in pain-free participants (15/53 vs. 1/25, P=0.01), and the frequency of temporal summation evoked by repetitive pinprick was higher in participants with pain than in pain-free participants (23/53 vs. 2/25, P=0.0009). The frequency of dynamic mechanical allodynia did not differ significantly between the two groups. CONCLUSION: These findings suggest that chronic pain after surgery for breast cancer is associated with sensory hyperexcitability and is a neuropathic pain condition.

KW - Breast Neoplasms

KW - Chronic Disease

KW - Cold Temperature

KW - Female

KW - Humans

KW - Middle Aged

KW - Pain Measurement

KW - Pain Threshold

KW - Pain, Postoperative

KW - Peripheral Nervous System Diseases

KW - Physical Stimulation

KW - Sensation

U2 - 10.1111/j.1399-6576.2009.01938.x

DO - 10.1111/j.1399-6576.2009.01938.x

M3 - Journal article

C2 - 19397505

VL - 53

SP - 800

EP - 806

JO - Acta Anaesthesiologica Scandinavica

JF - Acta Anaesthesiologica Scandinavica

SN - 0001-5172

IS - 6

ER -