Sensitization profile in hazelnut allergic children: Are co-sensitization to peanut and tree-nut relevant?

Background: Hazelnut is the most frequent cause of tree-nut allergy, where the most promising serological markers reported are cor a 9 and cor a 14. To understand the implication of component resolved diagnostics (CRD) in clinical hazelnut allergy, the course and comorbidity in hazelnut allergic patients' needs to be addressed. Method: All children ( 17.5 kU/l and Grass > 3 ISU. Sensitization to walnut, sesame and profilins were less common (15-30%) and mainly in low/moderate levels (1-3 ISU). Sensitization to other three-nuts, except for those 3 children with proven cashew and brazil nut allergy, and sensitization to LTP were insignificant. Conclusion: Hazelnut allergic children were sensitized to cor a 9, cor a 14 as well as birch and grass components, whereas sensitization to other tree-nuts are less frequent. Concomitant peanut allergy is common, but can be identified in the sensitization profile. One-third of children with hazelnut allergy will outgrew it, and half of those with concomitant peanut allergy will lose this as well.