Senescence of skeletal stem cells and their contribution to age-related bone loss

Eva M. Wölfel; Paula Fernandez-Guerra; Mikkel Ørnfeldt Nørgård; Shakespeare Jeromdesella; Pernille Kirkegaard Kjær; Anna Sofie Elkjær; Moustapha Kassem; Florence Figeac

doi:10.1016/j.mad.2024.111976

Senescence of skeletal stem cells and their contribution to age-related bone loss

Eva M. Wölfel^*, Paula Fernandez-Guerra, Mikkel Ørnfeldt Nørgård, Shakespeare Jeromdesella, Pernille Kirkegaard Kjær, Anna Sofie Elkjær, Moustapha Kassem, Florence Figeac

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Københavns Universitet

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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Abstract

Human aging is linked to bone loss, resulting in bone fragility and an increased risk of fractures. This is primarily due to an age-related decline in the function of bone-forming osteoblastic cells and accelerated cellular senescence within the bone microenvironment. Here, we provide a detailed discussion of the hypothesis that age-related defective bone formation is caused by senescence of skeletal stem cells, as they are the main source of bone forming osteoblastic cells and influence the composition of bone microenvironment. Furthermore, this review discusses potential strategies to target cellular senescence as an emerging approach to treat age-related bone loss.

Originalsprog	Engelsk
Artikelnummer	111976
Tidsskrift	Mechanisms of Ageing and Development
Vol/bind	221
ISSN	0047-6374
DOI	https://doi.org/10.1016/j.mad.2024.111976
Status	Udgivet - okt. 2024

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10.1016/j.mad.2024.111976Licens: CC BY

Open Access VersionForlagets udgivne version, 926 KBLicens: CC BY

Citationsformater

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abstract = "Human aging is linked to bone loss, resulting in bone fragility and an increased risk of fractures. This is primarily due to an age-related decline in the function of bone-forming osteoblastic cells and accelerated cellular senescence within the bone microenvironment. Here, we provide a detailed discussion of the hypothesis that age-related defective bone formation is caused by senescence of skeletal stem cells, as they are the main source of bone forming osteoblastic cells and influence the composition of bone microenvironment. Furthermore, this review discusses potential strategies to target cellular senescence as an emerging approach to treat age-related bone loss.",

keywords = "Age-related bone disease, Cellular senescence, Marrow stromal stem cells, Skeletal stem cells",

author = "W{\"o}lfel, {Eva M.} and Paula Fernandez-Guerra and N{\o}rg{\aa}rd, {Mikkel {\O}rnfeldt} and Shakespeare Jeromdesella and Kj{\ae}r, {Pernille Kirkegaard} and Elkj{\ae}r, {Anna Sofie} and Moustapha Kassem and Florence Figeac",

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AU - Wölfel, Eva M.

AU - Fernandez-Guerra, Paula

AU - Nørgård, Mikkel Ørnfeldt

AU - Jeromdesella, Shakespeare

AU - Kjær, Pernille Kirkegaard

AU - Elkjær, Anna Sofie

AU - Kassem, Moustapha

AU - Figeac, Florence

PY - 2024/10

Y1 - 2024/10

N2 - Human aging is linked to bone loss, resulting in bone fragility and an increased risk of fractures. This is primarily due to an age-related decline in the function of bone-forming osteoblastic cells and accelerated cellular senescence within the bone microenvironment. Here, we provide a detailed discussion of the hypothesis that age-related defective bone formation is caused by senescence of skeletal stem cells, as they are the main source of bone forming osteoblastic cells and influence the composition of bone microenvironment. Furthermore, this review discusses potential strategies to target cellular senescence as an emerging approach to treat age-related bone loss.

AB - Human aging is linked to bone loss, resulting in bone fragility and an increased risk of fractures. This is primarily due to an age-related decline in the function of bone-forming osteoblastic cells and accelerated cellular senescence within the bone microenvironment. Here, we provide a detailed discussion of the hypothesis that age-related defective bone formation is caused by senescence of skeletal stem cells, as they are the main source of bone forming osteoblastic cells and influence the composition of bone microenvironment. Furthermore, this review discusses potential strategies to target cellular senescence as an emerging approach to treat age-related bone loss.

KW - Age-related bone disease

KW - Cellular senescence

KW - Marrow stromal stem cells

KW - Skeletal stem cells

U2 - 10.1016/j.mad.2024.111976

DO - 10.1016/j.mad.2024.111976

M3 - Journal article

C2 - 39111640

AN - SCOPUS:85201399150

SN - 0047-6374

VL - 221

JO - Mechanisms of Ageing and Development

JF - Mechanisms of Ageing and Development

M1 - 111976

ER -

Senescence of skeletal stem cells and their contribution to age-related bone loss

Abstract

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