Self-rated health (SRH) and mortality in patients with mild Alzheimer's disease: A prospective study with 36 months follow-up

Frans Boch Waldorff, Volkert Siersma, Anni Brit Sternhagen Nielsen, Gunhild Waldemar

Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskning


Objectives and Study: In both epidemiological studies and in clinical trials the patients' own health perception, measured by a single question, known as perceived health, self-assessed health, or self-rated health (SRH). SRH has constantly been associated with future use of health care service and mortality independently of objective health measurements in various populations. The aim of this study was to investigate self-reported health and mortality among patients with mild Alzheimer's disease (AD) during a 36 month follow-up period in order to evaluate the potential of SRH as an overall health assesment measurement for this group of patients.

Methods: The data used in this study was part of the Danish Alzheimer Intervention study (DAISY). DAISY was a 3-year muliti-center single-blinded randomised controlled trial, with randomisation to an intensive support and counselling program or to usual care. SRH and potential counfounders were investigated in Cox proportional hazard models.

Results: A total of 321 patients with mild AD participated in this study. The mean age of the patients at baseline was 76.2 years (range 54-92), 46% were males and the average MMSE at baseline was 24.0, ranging from 20 to 30. A total of 208 (65%) rated their SRH as excellent or good, whereas 113 (35 %) rated their SRH as fair, poor or very poor. During the study period 54 patients died. After adjusting for portiential confounders poor SRH was not associated with subsequent mortality (HR 1.39, 95% CI: 0.74; 2.60).

Conclusions: SRH does not predict subsequent mortality in a population of patients with mild AD as compared to epidemiological studies. Based on our results we would be cautious in suggesting SRH as a global health score in patients suffering from mild AD, since SRH may not reflect the patients' mental disease severity.

StatusUdgivet - 2010
Udgivet eksterntJa
BegivenhedInternational Conference of Alzheimer's Disease - Thessaloniki, Grækenland
Varighed: 10. mar. 201013. mar. 2010
Konferencens nummer: 25


KonferenceInternational Conference of Alzheimer's Disease


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