Self-assembled composite matrix in a hierarchical 3D scaffold for bone tissue engineering

M Chen, D Q S Le, Anette Baatrup, J V Nygaard, S Hein, L Bjerre, M Kassem, Xuenong Zou, Cody Bünger

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Abstrakt

It is of high clinical relevance in bone tissue engineering that scaffolds promote a high seeding efficiency of cells capable of osteogenic differentiation, such as human bone marrow-derived mesenchymal stem cells (hMSC). We evaluated the effects of a novel polycaprolactone (PCL) scaffold on hMSC seeding efficiency, proliferation, distribution, and differentiation. Porous PCL meshes prepared by fused deposition modeling (FDM) were embedded in matrix of hyaluronic acid, methylated collagen, and terpolymer via polyelectrolyte complex coacervation. Scaffolds were cultured statically and dynamically in osteogenic stimulation medium for up to 28 days. Compared to naked PCL scaffolds, embedded scaffolds provided a higher cell seeding efficiency (t-test, p
OriginalsprogEngelsk
TidsskriftActa Biomaterialia
Vol/bind7
Udgave nummer5
Sider (fra-til)2244-2255
Antal sider12
ISSN1742-7061
DOI
StatusUdgivet - 2011

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