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Maria Kjærgaard, Katrine Prier Lindvig, Katrine Holtz Thorhauge, Stine Johansen, Johanne Kragh Hansen, Peter Andersen, Camilla Dalby Hansen, Helle Lindholm Schnefeld, Katrine Tholstrup Bech, Nikolaj Christian Torp, Mads Israelsen, Sönke Detlefsen, Isabel Graupera, Pere Ginès, Aleksander Krag*, Maja Thiele
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Background and Aims: Early detection of liver fibrosis is believed to promote lifestyle changes. We evaluated self-reported changes in alcohol intake, diet, exercise, and weight after participating in a screening study for liver fibrosis. Methods: We conducted a prospective screening study of individuals at risk of alcohol-related liver disease (ALD) or metabolic dysfunction–associated steatotic liver disease (MASLD). We provided lifestyle advice to all participants and evaluated lifestyle changes by questionnaires after 1 week and 6 months, with re-examination of a subgroup after 2 years. Results: A total of 1850 at risk of ALD and 2946 at risk of MASLD were included, of whom 383 (8%) were screening positive (transient elastography ≥8 kPa). A total of 84% replied to the 6-month questionnaire. In ALD participants, excessive drinking decreased from 46% to 32% after 6 months. Only 15% reported increased drinking, without differences between screening positive and negative individuals (P = .698). In high-risk drinkers, a positive screening test predicted abstinence or decreased alcohol use after 6 months (odds ratio, 2.45; 95% confidence interval, 1.32–4.57; P = .005). After 2 years, excessive drinking decreased from 52% to 41% in a subgroup of 752 individuals and a positive screening test predicted abstinence or decreased alcohol use after 2 years (odds ratio, 1.84; 95% confidence interval, 1.09–3.11, P = .023). MASLD participants showed similar improvements: 35% improved their diet, 22% exercised more, and 13% reported a weight loss ≥5% after 6 months. Conclusions: Screening for liver fibrosis is associated with sustained improvements in alcohol consumption, diet, weight, and exercise in at-risk ALD and MASLD. The changes are most pronounced in screening positive participants but not limited to this group.
Originalsprog | Engelsk |
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Tidsskrift | Clinical Gastroenterology and Hepatology |
Vol/bind | 22 |
Udgave nummer | 5 |
Sider (fra-til) | 1037-1047.e9 |
ISSN | 1542-3565 |
DOI | |
Status | Udgivet - maj 2024 |
Publikation: Afhandling › Ph.d.-afhandling