Scoring the tumor-stroma ratio in colon cancer: procedure and recommendations

G. W. van Pelt, S. Kjær-Frifeldt, J. H.J.M. van Krieken, R. Al Dieri, H. Morreau, R. A.E.M. Tollenaar, F. B. Sørensen, W. E. Mesker*

*Kontaktforfatter for dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

104 Downloads (Pure)

Abstrakt

The tumor-stroma ratio (TSR) has been reported as a strong, independent prognostic parameter in colon cancer as well as in other epithelial cancer types, and may be implemented to routine pathology diagnostics. The TSR is an easy technique, based on routine hematoxylin and eosin stained histological sections, estimating the amount of stroma present in the primary tumor. It links tumors with high stromal content to poor prognosis. The analysis time is less than 2 min with a low inter-observer variation. Scoring of the TSR has been validated in a number of independent international studies. In this manuscript, we provide a detailed technical description of estimating the TSR in colon cancer, including examples, pitfalls, and recommendations.

OriginalsprogEngelsk
TidsskriftVirchows Archiv
Vol/bind473
Udgave nummer4
Sider (fra-til)405-412
ISSN0945-6317
DOI
StatusUdgivet - 1. okt. 2018

Fingeraftryk

Dyk ned i forskningsemnerne om 'Scoring the tumor-stroma ratio in colon cancer: procedure and recommendations'. Sammen danner de et unikt fingeraftryk.

Citationsformater