Scoping review—the association between asthma and environmental chemicals

Tiina Mattila*, Tiina Santonen, Helle Raun Andersen, Andromachi Katsonouri, Tamás Szigeti, Maria Uhl, Wojciech Wąsowicz, Rosa Lange, Beatrice Bocca, Flavia Ruggieri, Marike Kolossa-Gehring, Denis A. Sarigiannis, Hanna Tolonen

*Kontaktforfatter for dette arbejde

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    Asthma is one of the most common chronic diseases worldwide affecting all age groups from children to the elderly. In addition to other factors such as smoking, air pollution and atopy, some environmental chemicals are shown or suspected to increase the risk of asthma, exacerbate asthma symptoms and cause other respiratory symptoms. In this scoping review, we report environmental chemicals, prioritized for investigation in the European Human Biomonitoring Initiative (HBM4EU), which are associated or possibly associated with asthma. The substance groups con-sidered to cause asthma through specific sensitization include: diisocyanates, hexavalent chromium Cr(VI) and possibly p-phenylenediamine (p-PDA). In epidemiological studies, polyaromatic hydrocarbons (PAHs) and organophosphate insecticides are associated with asthma, and phthalates, per-and polyfluoroalkyl substances (PFASs), pyrethroid insecticides, mercury, cad-mium, arsenic and lead are only potentially associated with asthma. As a conclusion, exposure to PAHs and some pesticides are associated with increased risk of asthma. Diisocyanates and Cr(VI) cause asthma with specific sensitization. For many environmental chemicals, current studies have provided contradicting results in relation to increased risk of asthma. Therefore, more research about exposure to environmental chemicals and risk of asthma is needed.

    TidsskriftInternational Journal of Environmental Research and Public Health
    Udgave nummer3
    StatusUdgivet - 1. feb. 2021

    Bibliografisk note

    Funding Information:
    Funding: The HBM4EU project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 733032 and received co-funding from the authors´ organizations.

    Publisher Copyright:
    © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

    Copyright 2021 Elsevier B.V., All rights reserved.

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