SARS-CoV-2 and Immunity: Natural Infection Compared with Vaccination

Simone Vespa; Pasquale Simeone; Giulia Catitti; Davide Buca; Domenico De Bellis; Laura Pierdomenico; Damiana Pieragostino; Ilaria Cicalini; Piero Del Boccio; Luca Natale; Trevor Owens; Reza Khorooshi; Vincenzo De Laurenzi; Liborio Stuppia; Paola Lanuti

doi:10.3390/ijms23168982

SARS-CoV-2 and Immunity: Natural Infection Compared with Vaccination

Simone Vespa, Pasquale Simeone, Giulia Catitti, Davide Buca, Domenico De Bellis, Laura Pierdomenico, Damiana Pieragostino^*, Ilaria Cicalini, Piero Del Boccio, Luca Natale, Trevor Owens, Reza Khorooshi, Vincenzo De Laurenzi, Liborio Stuppia, Paola Lanuti

^*Kontaktforfatter

University of Chieti-Pescara

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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Abstract

Recently, the protective and/or pathological role of virus-specific T cells in SARS-CoV-2 infection has been the focus of many studies. We investigated the anti-spike IgG levels and SARS-CoV-2-specific T cells in 125 donors (90 vaccinated with four different vaccine platforms, 16 individuals with a previous natural infection, and 19 not vaccinated donors who did not report previous SARS-CoV-2 infections). Our data show that anti-spike IgG titers were similar between naturally infected subjects and those vaccinated with adenoviral vector vaccines. Of note, all immunized donors produced memory CD4+ and/or CD8+ T cells. A sustained polyfunctionality of SARS-CoV-2-specific T cells in all immunized donors was also demonstrated. Altogether, our data suggest that the natural infection produces an overall response like that induced by vaccination. Therefore, this detailed immunological evaluation may be relevant for other vaccine efforts especially for the monitoring of novel vaccines effective against emerging virus variants.

Originalsprog	Engelsk
Artikelnummer	8982
Tidsskrift	International Journal of Molecular Sciences
Vol/bind	23
Udgave nummer	16
ISSN	1661-6596
DOI	https://doi.org/10.3390/ijms23168982
Status	Udgivet - 2. aug. 2022

Dokumenter og links

10.3390/ijms23168982Licens: CC BY

Open access versionForlagets udgivne version, 2,57 MBLicens: CC BY

Citationsformater

Vespa, S., Simeone, P., Catitti, G., Buca, D., De Bellis, D., Pierdomenico, L., Pieragostino, D., Cicalini, I., Del Boccio, P., Natale, L., Owens, T., Khorooshi, R., De Laurenzi, V., Stuppia, L., & Lanuti, P. (2022). SARS-CoV-2 and Immunity: Natural Infection Compared with Vaccination. International Journal of Molecular Sciences , 23(16), Artikel 8982. https://doi.org/10.3390/ijms23168982

@article{658744d0b44b4bb0a03871e8a751a05f,

title = "SARS-CoV-2 and Immunity: Natural Infection Compared with Vaccination",

abstract = "Recently, the protective and/or pathological role of virus-specific T cells in SARS-CoV-2 infection has been the focus of many studies. We investigated the anti-spike IgG levels and SARS-CoV-2-specific T cells in 125 donors (90 vaccinated with four different vaccine platforms, 16 individuals with a previous natural infection, and 19 not vaccinated donors who did not report previous SARS-CoV-2 infections). Our data show that anti-spike IgG titers were similar between naturally infected subjects and those vaccinated with adenoviral vector vaccines. Of note, all immunized donors produced memory CD4+ and/or CD8+ T cells. A sustained polyfunctionality of SARS-CoV-2-specific T cells in all immunized donors was also demonstrated. Altogether, our data suggest that the natural infection produces an overall response like that induced by vaccination. Therefore, this detailed immunological evaluation may be relevant for other vaccine efforts especially for the monitoring of novel vaccines effective against emerging virus variants.",

keywords = "COVID-19 vaccines, polychromatic flow cytometry, T-cell polyfunctionality",

author = "Simone Vespa and Pasquale Simeone and Giulia Catitti and Davide Buca and {De Bellis}, Domenico and Laura Pierdomenico and Damiana Pieragostino and Ilaria Cicalini and {Del Boccio}, Piero and Luca Natale and Trevor Owens and Reza Khorooshi and {De Laurenzi}, Vincenzo and Liborio Stuppia and Paola Lanuti",

year = "2022",

month = aug,

day = "2",

doi = "10.3390/ijms23168982",

language = "English",

volume = "23",

journal = "International Journal of Molecular Sciences ",

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Vespa, S, Simeone, P, Catitti, G, Buca, D, De Bellis, D, Pierdomenico, L, Pieragostino, D, Cicalini, I, Del Boccio, P, Natale, L, Owens, T , Khorooshi, R, De Laurenzi, V, Stuppia, L & Lanuti, P 2022, 'SARS-CoV-2 and Immunity: Natural Infection Compared with Vaccination', International Journal of Molecular Sciences , bind 23, nr. 16, 8982. https://doi.org/10.3390/ijms23168982

TY - JOUR

T1 - SARS-CoV-2 and Immunity

T2 - Natural Infection Compared with Vaccination

AU - Vespa, Simone

AU - Simeone, Pasquale

AU - Catitti, Giulia

AU - Buca, Davide

AU - De Bellis, Domenico

AU - Pierdomenico, Laura

AU - Pieragostino, Damiana

AU - Cicalini, Ilaria

AU - Del Boccio, Piero

AU - Natale, Luca

AU - Owens, Trevor

AU - Khorooshi, Reza

AU - De Laurenzi, Vincenzo

AU - Stuppia, Liborio

AU - Lanuti, Paola

PY - 2022/8/2

Y1 - 2022/8/2

N2 - Recently, the protective and/or pathological role of virus-specific T cells in SARS-CoV-2 infection has been the focus of many studies. We investigated the anti-spike IgG levels and SARS-CoV-2-specific T cells in 125 donors (90 vaccinated with four different vaccine platforms, 16 individuals with a previous natural infection, and 19 not vaccinated donors who did not report previous SARS-CoV-2 infections). Our data show that anti-spike IgG titers were similar between naturally infected subjects and those vaccinated with adenoviral vector vaccines. Of note, all immunized donors produced memory CD4+ and/or CD8+ T cells. A sustained polyfunctionality of SARS-CoV-2-specific T cells in all immunized donors was also demonstrated. Altogether, our data suggest that the natural infection produces an overall response like that induced by vaccination. Therefore, this detailed immunological evaluation may be relevant for other vaccine efforts especially for the monitoring of novel vaccines effective against emerging virus variants.

AB - Recently, the protective and/or pathological role of virus-specific T cells in SARS-CoV-2 infection has been the focus of many studies. We investigated the anti-spike IgG levels and SARS-CoV-2-specific T cells in 125 donors (90 vaccinated with four different vaccine platforms, 16 individuals with a previous natural infection, and 19 not vaccinated donors who did not report previous SARS-CoV-2 infections). Our data show that anti-spike IgG titers were similar between naturally infected subjects and those vaccinated with adenoviral vector vaccines. Of note, all immunized donors produced memory CD4+ and/or CD8+ T cells. A sustained polyfunctionality of SARS-CoV-2-specific T cells in all immunized donors was also demonstrated. Altogether, our data suggest that the natural infection produces an overall response like that induced by vaccination. Therefore, this detailed immunological evaluation may be relevant for other vaccine efforts especially for the monitoring of novel vaccines effective against emerging virus variants.

KW - COVID-19 vaccines

KW - polychromatic flow cytometry

KW - T-cell polyfunctionality

U2 - 10.3390/ijms23168982

DO - 10.3390/ijms23168982

M3 - Journal article

C2 - 36012246

AN - SCOPUS:85137127116

SN - 1661-6596

VL - 23

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

IS - 16

M1 - 8982

ER -

SARS-CoV-2 and Immunity: Natural Infection Compared with Vaccination

Abstract

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