Salivary agglutinin/DMBT1SAG expression is up-regulated in the presence of salivary gland tumors.

F J Bikker, J E van der Wal, A J M Ligtenberg, J Mollenhauer, J M A de Blieck-Hogervorst, I van der Waal, A Poustka, A V Nieuw Amerongen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Udgivelsesdato: 2004-Jul
OriginalsprogEngelsk
TidsskriftJournal of Dental Research
Vol/bind83
Udgave nummer7
Sider (fra-til)567-71
Antal sider4
ISSN0022-0345
StatusUdgivet - 1. jul. 2004

Fingeraftryk

Glandular and Epithelial Neoplasms
Agglutinins
Neoplasms
Gastrointestinal Tract

Citer dette

Bikker, F. J., van der Wal, J. E., Ligtenberg, A. J. M., Mollenhauer, J., de Blieck-Hogervorst, J. M. A., van der Waal, I., ... Nieuw Amerongen, A. V. (2004). Salivary agglutinin/DMBT1SAG expression is up-regulated in the presence of salivary gland tumors. Journal of Dental Research, 83(7), 567-71.
Bikker, F J ; van der Wal, J E ; Ligtenberg, A J M ; Mollenhauer, J ; de Blieck-Hogervorst, J M A ; van der Waal, I ; Poustka, A ; Nieuw Amerongen, A V. / Salivary agglutinin/DMBT1SAG expression is up-regulated in the presence of salivary gland tumors. I: Journal of Dental Research. 2004 ; Bind 83, Nr. 7. s. 567-71.
@article{c864a5f057fb11ddb1a1000ea68e967b,
title = "Salivary agglutinin/DMBT1SAG expression is up-regulated in the presence of salivary gland tumors.",
abstract = "Salivary agglutinin (SAG) is encoded by the gene Deleted in Malignant Brain Tumors 1 (DMBT1) and represents the salivary variant of DMBT1 (DMBT1(SAG)). While SAG is a bona fide anti-caries factor, DMBT1 was proposed as a candidate tumor-suppressor for brain, digestive tract, and lung cancer. Though DMBT1(SAG) is expressed in the salivary glands, its expression in salivary gland tumors is unknown. Here we analyzed DMBT1(SAG) expression in 20 salivary gland tumors and 14 tumor-flanking tissues by immunohistochemistry. DMBT1(SAG) in salivary gland tumors resembles the changes of expression levels known from DMBT1 in tumors in other cancer types. Particularly, DMBT1(SAG) was up-regulated in 10/14 tumor-flanking tissues, and a strong staining of the luminal content in the tumor and/or the tumor-flanking tissue was observed in 14/20 cases. This suggests that, in addition to its role in caries defense, SAG may serve as a potential tumor indicator and/or tumor suppressor in salivary gland tissue.",
keywords = "Agglutinins, Biopsy, Carcinoma, Gene Expression Regulation, Neoplastic, Humans, Immunohistochemistry, Neoplasm Proteins, Receptors, Cell Surface, Receptors, Immunologic, Salivary Gland Neoplasms, Salivary Glands, Salivary Proteins, Tumor Markers, Biological, Up-Regulation",
author = "Bikker, {F J} and {van der Wal}, {J E} and Ligtenberg, {A J M} and J Mollenhauer and {de Blieck-Hogervorst}, {J M A} and {van der Waal}, I and A Poustka and {Nieuw Amerongen}, {A V}",
year = "2004",
month = "7",
day = "1",
language = "English",
volume = "83",
pages = "567--71",
journal = "Journal of Dental Research",
issn = "0022-0345",
publisher = "SAGE Publications",
number = "7",

}

Bikker, FJ, van der Wal, JE, Ligtenberg, AJM, Mollenhauer, J, de Blieck-Hogervorst, JMA, van der Waal, I, Poustka, A & Nieuw Amerongen, AV 2004, 'Salivary agglutinin/DMBT1SAG expression is up-regulated in the presence of salivary gland tumors.', Journal of Dental Research, bind 83, nr. 7, s. 567-71.

Salivary agglutinin/DMBT1SAG expression is up-regulated in the presence of salivary gland tumors. / Bikker, F J; van der Wal, J E; Ligtenberg, A J M; Mollenhauer, J; de Blieck-Hogervorst, J M A; van der Waal, I; Poustka, A; Nieuw Amerongen, A V.

I: Journal of Dental Research, Bind 83, Nr. 7, 01.07.2004, s. 567-71.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Salivary agglutinin/DMBT1SAG expression is up-regulated in the presence of salivary gland tumors.

AU - Bikker, F J

AU - van der Wal, J E

AU - Ligtenberg, A J M

AU - Mollenhauer, J

AU - de Blieck-Hogervorst, J M A

AU - van der Waal, I

AU - Poustka, A

AU - Nieuw Amerongen, A V

PY - 2004/7/1

Y1 - 2004/7/1

N2 - Salivary agglutinin (SAG) is encoded by the gene Deleted in Malignant Brain Tumors 1 (DMBT1) and represents the salivary variant of DMBT1 (DMBT1(SAG)). While SAG is a bona fide anti-caries factor, DMBT1 was proposed as a candidate tumor-suppressor for brain, digestive tract, and lung cancer. Though DMBT1(SAG) is expressed in the salivary glands, its expression in salivary gland tumors is unknown. Here we analyzed DMBT1(SAG) expression in 20 salivary gland tumors and 14 tumor-flanking tissues by immunohistochemistry. DMBT1(SAG) in salivary gland tumors resembles the changes of expression levels known from DMBT1 in tumors in other cancer types. Particularly, DMBT1(SAG) was up-regulated in 10/14 tumor-flanking tissues, and a strong staining of the luminal content in the tumor and/or the tumor-flanking tissue was observed in 14/20 cases. This suggests that, in addition to its role in caries defense, SAG may serve as a potential tumor indicator and/or tumor suppressor in salivary gland tissue.

AB - Salivary agglutinin (SAG) is encoded by the gene Deleted in Malignant Brain Tumors 1 (DMBT1) and represents the salivary variant of DMBT1 (DMBT1(SAG)). While SAG is a bona fide anti-caries factor, DMBT1 was proposed as a candidate tumor-suppressor for brain, digestive tract, and lung cancer. Though DMBT1(SAG) is expressed in the salivary glands, its expression in salivary gland tumors is unknown. Here we analyzed DMBT1(SAG) expression in 20 salivary gland tumors and 14 tumor-flanking tissues by immunohistochemistry. DMBT1(SAG) in salivary gland tumors resembles the changes of expression levels known from DMBT1 in tumors in other cancer types. Particularly, DMBT1(SAG) was up-regulated in 10/14 tumor-flanking tissues, and a strong staining of the luminal content in the tumor and/or the tumor-flanking tissue was observed in 14/20 cases. This suggests that, in addition to its role in caries defense, SAG may serve as a potential tumor indicator and/or tumor suppressor in salivary gland tissue.

KW - Agglutinins

KW - Biopsy

KW - Carcinoma

KW - Gene Expression Regulation, Neoplastic

KW - Humans

KW - Immunohistochemistry

KW - Neoplasm Proteins

KW - Receptors, Cell Surface

KW - Receptors, Immunologic

KW - Salivary Gland Neoplasms

KW - Salivary Glands

KW - Salivary Proteins

KW - Tumor Markers, Biological

KW - Up-Regulation

M3 - Journal article

VL - 83

SP - 567

EP - 571

JO - Journal of Dental Research

JF - Journal of Dental Research

SN - 0022-0345

IS - 7

ER -

Bikker FJ, van der Wal JE, Ligtenberg AJM, Mollenhauer J, de Blieck-Hogervorst JMA, van der Waal I et al. Salivary agglutinin/DMBT1SAG expression is up-regulated in the presence of salivary gland tumors. Journal of Dental Research. 2004 jul 1;83(7):567-71.