Sacroiliac Joint Asymmetry Regarding Inflammation and Bone Turnover: Assessment by FDG and NaF PET/CT

Abdullah Al-Zaghal, Dani P Yellanki, Esha Kothekar, Thomas J Werner, Poul F Høilund-Carlsen, Abass Alavi

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Objectives: This study was undertaken to determine the role of computed tomography (CT)-based methodology to segment the SI joint and quantify the metabolic activity using positron emission tomography (PET). We measured tracer uptake in the right and left SI joints independently to look for differences between the two sides. Further, we correlated tracer uptake with BMI and studied the inter-observer variation with regard to estimated tracer uptake in the SI joints.

Methods: In this retrospective study, a total of 103 subjects (48 females, 55 males) from the CAMONA study database collected 2012-2016 at Odense University Hospital in Denmark were included. Mean age was 48±14.59 years, mean BMI was 26.68±4.31 kg/m2. The SI joints were segmented on fused PET/CT images using a 3D growing algorithm with adjustable upper and lower Hounsfield Units (HU) thresholds. The metabolic activities on the two sides were correlated with BMI.

Results: For FDG, we found a higher average SUVmean on the right side (right: 1.3±0.33, left: 1.13±0.30; <0.0001). Similarly, for NaF, the uptake was higher on the right side (right: 5.9±1.29, left: 4.27±1.23; <0.0001). Positive correlations were present between BMI and FDG uptake (P<0.01) as well as NaF uptake (P<0.01).

Conclusion: The PET-based molecular imaging probes along with the CT-based segmentation techniques revealed a significant difference in the metabolic activity between the two SI joints with higher inflammation and reactive bone formation on the right side. FDG and NaF uptakes correlated significantly and positively with BMI.

OriginalsprogEngelsk
TidsskriftAsia Oceania Journal of Nuclear Medicine and Biology
Vol/bind7
Udgave nummer2
Sider (fra-til)108-114
ISSN2322-5718
DOI
StatusUdgivet - 2019

Fingeraftryk

Sacroiliac Joint
Joints
Observer Variation
Denmark
Osteogenesis
Retrospective Studies
Positron Emission Tomography Computed Tomography
Databases

Citer dette

Al-Zaghal, Abdullah ; Yellanki, Dani P ; Kothekar, Esha ; Werner, Thomas J ; Høilund-Carlsen, Poul F ; Alavi, Abass. / Sacroiliac Joint Asymmetry Regarding Inflammation and Bone Turnover : Assessment by FDG and NaF PET/CT. I: Asia Oceania Journal of Nuclear Medicine and Biology. 2019 ; Bind 7, Nr. 2. s. 108-114.
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title = "Sacroiliac Joint Asymmetry Regarding Inflammation and Bone Turnover: Assessment by FDG and NaF PET/CT",
abstract = "Objectives: This study was undertaken to determine the role of computed tomography (CT)-based methodology to segment the SI joint and quantify the metabolic activity using positron emission tomography (PET). We measured tracer uptake in the right and left SI joints independently to look for differences between the two sides. Further, we correlated tracer uptake with BMI and studied the inter-observer variation with regard to estimated tracer uptake in the SI joints.Methods: In this retrospective study, a total of 103 subjects (48 females, 55 males) from the CAMONA study database collected 2012-2016 at Odense University Hospital in Denmark were included. Mean age was 48±14.59 years, mean BMI was 26.68±4.31 kg/m2. The SI joints were segmented on fused PET/CT images using a 3D growing algorithm with adjustable upper and lower Hounsfield Units (HU) thresholds. The metabolic activities on the two sides were correlated with BMI.Results: For FDG, we found a higher average SUVmean on the right side (right: 1.3±0.33, left: 1.13±0.30; <0.0001). Similarly, for NaF, the uptake was higher on the right side (right: 5.9±1.29, left: 4.27±1.23; <0.0001). Positive correlations were present between BMI and FDG uptake (P<0.01) as well as NaF uptake (P<0.01).Conclusion: The PET-based molecular imaging probes along with the CT-based segmentation techniques revealed a significant difference in the metabolic activity between the two SI joints with higher inflammation and reactive bone formation on the right side. FDG and NaF uptakes correlated significantly and positively with BMI.",
author = "Abdullah Al-Zaghal and Yellanki, {Dani P} and Esha Kothekar and Werner, {Thomas J} and H{\o}ilund-Carlsen, {Poul F} and Abass Alavi",
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doi = "10.22038/AOJNMB.2019.40820.1275",
language = "English",
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pages = "108--114",
journal = "Asia Oceania Journal of Nuclear Medicine and Biology",
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Sacroiliac Joint Asymmetry Regarding Inflammation and Bone Turnover : Assessment by FDG and NaF PET/CT. / Al-Zaghal, Abdullah; Yellanki, Dani P; Kothekar, Esha; Werner, Thomas J; Høilund-Carlsen, Poul F; Alavi, Abass.

I: Asia Oceania Journal of Nuclear Medicine and Biology, Bind 7, Nr. 2, 2019, s. 108-114.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Sacroiliac Joint Asymmetry Regarding Inflammation and Bone Turnover

T2 - Assessment by FDG and NaF PET/CT

AU - Al-Zaghal, Abdullah

AU - Yellanki, Dani P

AU - Kothekar, Esha

AU - Werner, Thomas J

AU - Høilund-Carlsen, Poul F

AU - Alavi, Abass

PY - 2019

Y1 - 2019

N2 - Objectives: This study was undertaken to determine the role of computed tomography (CT)-based methodology to segment the SI joint and quantify the metabolic activity using positron emission tomography (PET). We measured tracer uptake in the right and left SI joints independently to look for differences between the two sides. Further, we correlated tracer uptake with BMI and studied the inter-observer variation with regard to estimated tracer uptake in the SI joints.Methods: In this retrospective study, a total of 103 subjects (48 females, 55 males) from the CAMONA study database collected 2012-2016 at Odense University Hospital in Denmark were included. Mean age was 48±14.59 years, mean BMI was 26.68±4.31 kg/m2. The SI joints were segmented on fused PET/CT images using a 3D growing algorithm with adjustable upper and lower Hounsfield Units (HU) thresholds. The metabolic activities on the two sides were correlated with BMI.Results: For FDG, we found a higher average SUVmean on the right side (right: 1.3±0.33, left: 1.13±0.30; <0.0001). Similarly, for NaF, the uptake was higher on the right side (right: 5.9±1.29, left: 4.27±1.23; <0.0001). Positive correlations were present between BMI and FDG uptake (P<0.01) as well as NaF uptake (P<0.01).Conclusion: The PET-based molecular imaging probes along with the CT-based segmentation techniques revealed a significant difference in the metabolic activity between the two SI joints with higher inflammation and reactive bone formation on the right side. FDG and NaF uptakes correlated significantly and positively with BMI.

AB - Objectives: This study was undertaken to determine the role of computed tomography (CT)-based methodology to segment the SI joint and quantify the metabolic activity using positron emission tomography (PET). We measured tracer uptake in the right and left SI joints independently to look for differences between the two sides. Further, we correlated tracer uptake with BMI and studied the inter-observer variation with regard to estimated tracer uptake in the SI joints.Methods: In this retrospective study, a total of 103 subjects (48 females, 55 males) from the CAMONA study database collected 2012-2016 at Odense University Hospital in Denmark were included. Mean age was 48±14.59 years, mean BMI was 26.68±4.31 kg/m2. The SI joints were segmented on fused PET/CT images using a 3D growing algorithm with adjustable upper and lower Hounsfield Units (HU) thresholds. The metabolic activities on the two sides were correlated with BMI.Results: For FDG, we found a higher average SUVmean on the right side (right: 1.3±0.33, left: 1.13±0.30; <0.0001). Similarly, for NaF, the uptake was higher on the right side (right: 5.9±1.29, left: 4.27±1.23; <0.0001). Positive correlations were present between BMI and FDG uptake (P<0.01) as well as NaF uptake (P<0.01).Conclusion: The PET-based molecular imaging probes along with the CT-based segmentation techniques revealed a significant difference in the metabolic activity between the two SI joints with higher inflammation and reactive bone formation on the right side. FDG and NaF uptakes correlated significantly and positively with BMI.

U2 - 10.22038/AOJNMB.2019.40820.1275

DO - 10.22038/AOJNMB.2019.40820.1275

M3 - Journal article

C2 - 31380449

VL - 7

SP - 108

EP - 114

JO - Asia Oceania Journal of Nuclear Medicine and Biology

JF - Asia Oceania Journal of Nuclear Medicine and Biology

SN - 2322-5718

IS - 2

ER -