Rubidium uptake of mononuclear leukocytes from normotensive and borderline hypertensive first degree relatives to patients with essential hypertension

Torben Johansen, J R Nielsen, L Poulsgård, T Knudsen, K E Pedersen, N A Klitgaard

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Uptake of 86Rubidium of mononuclear leukocytes (MNL) was used as a measure of cellular sodium-potassium pump activity. 86Rb-uptake was determined with the pump stimulated mainly from inside the cells by sodium as well as with a combined stimulation from inside by sodium and from outside by Rb. In the first case there was an increased pump activity in MNL from borderline hypertensive offspring of hypertensive patients (BHO), and this may be related to an increased number of pump sites observed previously (10). Estimation of maximal pump activity (Vmax) of MNL suggested that Vmax of each pump site in MNL from BHO may be decreased compared to control value of MNL from healthy normotensive subjects.
OriginalsprogEngelsk
TidsskriftActa medica Scandinavica. Supplementum
Vol/bind693
Sider (fra-til)65-8
Antal sider4
ISSN0365-463X
DOI
StatusUdgivet - 1985

Fingeraftryk

Rubidium
Sodium-Potassium-Exchanging ATPase
Essential Hypertension

Citer dette

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title = "Rubidium uptake of mononuclear leukocytes from normotensive and borderline hypertensive first degree relatives to patients with essential hypertension",
abstract = "Uptake of 86Rubidium of mononuclear leukocytes (MNL) was used as a measure of cellular sodium-potassium pump activity. 86Rb-uptake was determined with the pump stimulated mainly from inside the cells by sodium as well as with a combined stimulation from inside by sodium and from outside by Rb. In the first case there was an increased pump activity in MNL from borderline hypertensive offspring of hypertensive patients (BHO), and this may be related to an increased number of pump sites observed previously (10). Estimation of maximal pump activity (Vmax) of MNL suggested that Vmax of each pump site in MNL from BHO may be decreased compared to control value of MNL from healthy normotensive subjects.",
keywords = "Humans, Hypertension, Leukocytes, Potassium, Radioisotopes, Rubidium, Sodium",
author = "Torben Johansen and Nielsen, {J R} and L Poulsg{\aa}rd and T Knudsen and Pedersen, {K E} and Klitgaard, {N A}",
year = "1985",
doi = "10.1111/j.0954-6820.1985.tb08779.x",
language = "English",
volume = "693",
pages = "65--8",
journal = "Acta medica Scandinavica. Supplementum",
issn = "0365-463X",
publisher = "Almgvist & Wiksells",

}

Rubidium uptake of mononuclear leukocytes from normotensive and borderline hypertensive first degree relatives to patients with essential hypertension. / Johansen, Torben; Nielsen, J R; Poulsgård, L; Knudsen, T; Pedersen, K E; Klitgaard, N A.

I: Acta medica Scandinavica. Supplementum, Bind 693, 1985, s. 65-8.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Rubidium uptake of mononuclear leukocytes from normotensive and borderline hypertensive first degree relatives to patients with essential hypertension

AU - Johansen, Torben

AU - Nielsen, J R

AU - Poulsgård, L

AU - Knudsen, T

AU - Pedersen, K E

AU - Klitgaard, N A

PY - 1985

Y1 - 1985

N2 - Uptake of 86Rubidium of mononuclear leukocytes (MNL) was used as a measure of cellular sodium-potassium pump activity. 86Rb-uptake was determined with the pump stimulated mainly from inside the cells by sodium as well as with a combined stimulation from inside by sodium and from outside by Rb. In the first case there was an increased pump activity in MNL from borderline hypertensive offspring of hypertensive patients (BHO), and this may be related to an increased number of pump sites observed previously (10). Estimation of maximal pump activity (Vmax) of MNL suggested that Vmax of each pump site in MNL from BHO may be decreased compared to control value of MNL from healthy normotensive subjects.

AB - Uptake of 86Rubidium of mononuclear leukocytes (MNL) was used as a measure of cellular sodium-potassium pump activity. 86Rb-uptake was determined with the pump stimulated mainly from inside the cells by sodium as well as with a combined stimulation from inside by sodium and from outside by Rb. In the first case there was an increased pump activity in MNL from borderline hypertensive offspring of hypertensive patients (BHO), and this may be related to an increased number of pump sites observed previously (10). Estimation of maximal pump activity (Vmax) of MNL suggested that Vmax of each pump site in MNL from BHO may be decreased compared to control value of MNL from healthy normotensive subjects.

KW - Humans

KW - Hypertension

KW - Leukocytes

KW - Potassium

KW - Radioisotopes

KW - Rubidium

KW - Sodium

U2 - 10.1111/j.0954-6820.1985.tb08779.x

DO - 10.1111/j.0954-6820.1985.tb08779.x

M3 - Journal article

VL - 693

SP - 65

EP - 68

JO - Acta medica Scandinavica. Supplementum

JF - Acta medica Scandinavica. Supplementum

SN - 0365-463X

ER -