TY - JOUR
T1 - Role of RhoA-ROCK signaling in Parkinson's disease
AU - Iyer, Mahalaxmi
AU - Subramaniam, Mohana Devi
AU - Venkatesan, Dhivya
AU - Cho, Ssang-Goo
AU - Ryding, Matias
AU - Meyer, Morten
AU - Vellingiri, Balachandar
N1 - Copyright © 2020 Elsevier B.V. All rights reserved.
PY - 2021/3/5
Y1 - 2021/3/5
N2 - Parkinson's disease (PD) is a complex and widespread neurodegenerative disease characterized by depletion of midbrain dopaminergic (DA) neurons. Key issues are the development of therapies that can stop or reverse the disease progression, identification of dependable biomarkers, and better understanding of the pathophysiological mechanisms of PD. RhoA-ROCK signals appear to have an important role in PD symptoms, making it a possible approach for PD treatment strategies. Activation of RhoA-ROCK (Rho-associated coiled-coil containing protein kinase) appears to stimulate various PD risk factors including aggregation of alpha-synuclein (αSyn), dysregulation of autophagy, and activation of apoptosis. This manuscript reviews current updates about the biology and function of the RhoA-ROCK pathway and discusses the possible role of this signaling pathway in causing the pathogenesis of PD. We conclude that inhibition of the RhoA-ROCK signaling pathway may have high translational potential and could be a promising therapeutic target in PD.
AB - Parkinson's disease (PD) is a complex and widespread neurodegenerative disease characterized by depletion of midbrain dopaminergic (DA) neurons. Key issues are the development of therapies that can stop or reverse the disease progression, identification of dependable biomarkers, and better understanding of the pathophysiological mechanisms of PD. RhoA-ROCK signals appear to have an important role in PD symptoms, making it a possible approach for PD treatment strategies. Activation of RhoA-ROCK (Rho-associated coiled-coil containing protein kinase) appears to stimulate various PD risk factors including aggregation of alpha-synuclein (αSyn), dysregulation of autophagy, and activation of apoptosis. This manuscript reviews current updates about the biology and function of the RhoA-ROCK pathway and discusses the possible role of this signaling pathway in causing the pathogenesis of PD. We conclude that inhibition of the RhoA-ROCK signaling pathway may have high translational potential and could be a promising therapeutic target in PD.
U2 - 10.1016/j.ejphar.2020.173815
DO - 10.1016/j.ejphar.2020.173815
M3 - Journal article
C2 - 33345850
SN - 0014-2999
VL - 894
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
M1 - 173815
ER -