Role of free fatty acid signaling in islet function

E Lorza-Gil Gil, Gerhard K H Przemeck, Elisabeth Rexen Ulven, Sibylle Sabrautzki, M. Panse, Felicia Gerst, H. U. Haring, Trond Ulven, Martin Hrabé de Angelis, Susanne Ullrich

Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

Abstrakt

Acute exposure of islets to long chain fatty acids amplifies glucose-stimulated insulin secretion (GSIS) in pancreatic beta-cells through activation of the free fatty acid receptor 1 (FFAR1). In accordance, palmitate-induced secretion was largely reduced in islets of Ffar1 -/- mice and of mice carrying the mutation R258W in Ffar1 gene. Glucose tolerance, however, was impaired in Ffar1 -/- mice but improved in R258W mutant mice. In Ffar1 -/- mouse islets, the mRNA level of Ffar3 was reduced. Ffar3 and Ffar2 are short chain fatty acid receptors (SCFA). Their function in beta-cells is still controversial. Here we examined the expression and role of Ffar2 and Ffar3 in beta-cells.
OriginalsprogEngelsk
TidsskriftDiabetologie und Stoffwechsel
Vol/bind13
Udgave nummerS01
Sider (fra-til)6-6
ISSN1861-9002
DOI
StatusUdgivet - 2018
BegivenhedDiabetes Kongress 2018: Diabetes Congress of the German Diabetes Association - Berlin, Tyskland
Varighed: 9. maj 201812. maj 2018
Konferencens nummer: 53

Konference

KonferenceDiabetes Kongress 2018
Nummer53
LandTyskland
ByBerlin
Periode09/05/201812/05/2018

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