Role of charged lipids in membrane structures — Insight given by simulations

Sanja Pöyry, Ilpo Vattulainen*

*Kontaktforfatter for dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Lipids and proteins are the main components of cell membranes. It is becoming increasingly clear that lipids, in addition to providing an environment for proteins to work in, are in many cases also able to modulate the structure and function of those proteins. Particularly charged lipids such as phosphatidylinositols and phosphatidylserines are involved in several examples of such effects. Molecular dynamics simulations have proved an invaluable tool in exploring these aspects. This so-called computational microscope can provide both complementing explanations for the experimental results and guide experiments to fruitful directions. In this paper, we review studies that have utilized molecular dynamics simulations to unravel the roles of charged lipids in membrane structures. We focus on lipids as active constituents of the membranes, affecting both general membrane properties as well as non-lipid membrane components, mainly proteins. This article is part of a Special Issue entitled: Biosimulations edited by Ilpo Vattulainen and Tomasz Róg.

OriginalsprogEngelsk
TidsskriftBiochimica et Biophysica Acta - Biomembranes
Vol/bind1858
Udgave nummer10
Sider (fra-til)2322-2333
ISSN0005-2736
DOI
StatusUdgivet - 2016

Fingeraftryk

Membrane structures
Membrane Lipids
Lipids
Molecular Dynamics Simulation
Membranes
Proteins
Molecular dynamics
Phosphatidylserines
Computer simulation
Cell membranes
Phosphatidylinositols
Cell Membrane
Microscopes
Experiments

Citer dette

Pöyry, Sanja ; Vattulainen, Ilpo. / Role of charged lipids in membrane structures — Insight given by simulations. I: Biochimica et Biophysica Acta - Biomembranes. 2016 ; Bind 1858, Nr. 10. s. 2322-2333.
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abstract = "Lipids and proteins are the main components of cell membranes. It is becoming increasingly clear that lipids, in addition to providing an environment for proteins to work in, are in many cases also able to modulate the structure and function of those proteins. Particularly charged lipids such as phosphatidylinositols and phosphatidylserines are involved in several examples of such effects. Molecular dynamics simulations have proved an invaluable tool in exploring these aspects. This so-called computational microscope can provide both complementing explanations for the experimental results and guide experiments to fruitful directions. In this paper, we review studies that have utilized molecular dynamics simulations to unravel the roles of charged lipids in membrane structures. We focus on lipids as active constituents of the membranes, affecting both general membrane properties as well as non-lipid membrane components, mainly proteins. This article is part of a Special Issue entitled: Biosimulations edited by Ilpo Vattulainen and Tomasz R{\'o}g.",
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Role of charged lipids in membrane structures — Insight given by simulations. / Pöyry, Sanja; Vattulainen, Ilpo.

I: Biochimica et Biophysica Acta - Biomembranes, Bind 1858, Nr. 10, 2016, s. 2322-2333.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Role of charged lipids in membrane structures — Insight given by simulations

AU - Pöyry, Sanja

AU - Vattulainen, Ilpo

PY - 2016

Y1 - 2016

N2 - Lipids and proteins are the main components of cell membranes. It is becoming increasingly clear that lipids, in addition to providing an environment for proteins to work in, are in many cases also able to modulate the structure and function of those proteins. Particularly charged lipids such as phosphatidylinositols and phosphatidylserines are involved in several examples of such effects. Molecular dynamics simulations have proved an invaluable tool in exploring these aspects. This so-called computational microscope can provide both complementing explanations for the experimental results and guide experiments to fruitful directions. In this paper, we review studies that have utilized molecular dynamics simulations to unravel the roles of charged lipids in membrane structures. We focus on lipids as active constituents of the membranes, affecting both general membrane properties as well as non-lipid membrane components, mainly proteins. This article is part of a Special Issue entitled: Biosimulations edited by Ilpo Vattulainen and Tomasz Róg.

AB - Lipids and proteins are the main components of cell membranes. It is becoming increasingly clear that lipids, in addition to providing an environment for proteins to work in, are in many cases also able to modulate the structure and function of those proteins. Particularly charged lipids such as phosphatidylinositols and phosphatidylserines are involved in several examples of such effects. Molecular dynamics simulations have proved an invaluable tool in exploring these aspects. This so-called computational microscope can provide both complementing explanations for the experimental results and guide experiments to fruitful directions. In this paper, we review studies that have utilized molecular dynamics simulations to unravel the roles of charged lipids in membrane structures. We focus on lipids as active constituents of the membranes, affecting both general membrane properties as well as non-lipid membrane components, mainly proteins. This article is part of a Special Issue entitled: Biosimulations edited by Ilpo Vattulainen and Tomasz Róg.

KW - Cardiolipin

KW - Lipid membrane

KW - Lipid–protein interactions

KW - Phosphatidylinositol

KW - Phosphatidylserine

U2 - 10.1016/j.bbamem.2016.03.016

DO - 10.1016/j.bbamem.2016.03.016

M3 - Journal article

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AN - SCOPUS:84961924291

VL - 1858

SP - 2322

EP - 2333

JO - B B A - Biomembranes

JF - B B A - Biomembranes

SN - 0005-2736

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