Role of acylCoA binding protein in acylCoA transport, metabolism and cell signaling

J Knudsen, M V Jensen, J K Hansen, Nils J. Færgeman, T B Neergaard, B Gaigg

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Long chain acylCoA esters (LCAs) act both as substrates and intermediates in intermediary metabolism and as regulators in various intracellular functions. AcylCoA binding protein (ACBP) binds LCAs with high affinity and is believed to play an important role in intracellular acylCoA transport and pool formation and therefore also for the function of LCAs as metabolites and regulators of cellular functions [1]. The major factors controlling the free concentration of cytosol long chain acylCoA ester (LCA) include ACBP [2], sterol carrier protein 2 (SCP2) [3] and fatty acid binding protein (FABP) [4]. Additional factors affecting the concentration of free LCA include feed back inhibition of the acylCoA synthetase [5], binding to acylCoA receptors (LCA-regulated molecules and enzymes), binding to membranes and the activity of acylCoA hydrolases [6].
OriginalsprogEngelsk
TidsskriftMolecular and Cellular Biochemistry
Vol/bind192
Udgave nummer1-2
Sider (fra-til)95-103
Antal sider9
ISSN0300-8177
StatusUdgivet - 1999

Fingeraftryk

Cell signaling
Metabolism
Carrier Proteins
Esters
Fatty Acid-Binding Proteins
Hydrolases
Ligases
Metabolites
Cytosol
Membranes
Feedback
Molecules
Substrates
Enzymes

Citer dette

Knudsen, J., Jensen, M. V., Hansen, J. K., Færgeman, N. J., Neergaard, T. B., & Gaigg, B. (1999). Role of acylCoA binding protein in acylCoA transport, metabolism and cell signaling. Molecular and Cellular Biochemistry, 192(1-2), 95-103.
Knudsen, J ; Jensen, M V ; Hansen, J K ; Færgeman, Nils J. ; Neergaard, T B ; Gaigg, B. / Role of acylCoA binding protein in acylCoA transport, metabolism and cell signaling. I: Molecular and Cellular Biochemistry. 1999 ; Bind 192, Nr. 1-2. s. 95-103.
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title = "Role of acylCoA binding protein in acylCoA transport, metabolism and cell signaling",
abstract = "Long chain acylCoA esters (LCAs) act both as substrates and intermediates in intermediary metabolism and as regulators in various intracellular functions. AcylCoA binding protein (ACBP) binds LCAs with high affinity and is believed to play an important role in intracellular acylCoA transport and pool formation and therefore also for the function of LCAs as metabolites and regulators of cellular functions [1]. The major factors controlling the free concentration of cytosol long chain acylCoA ester (LCA) include ACBP [2], sterol carrier protein 2 (SCP2) [3] and fatty acid binding protein (FABP) [4]. Additional factors affecting the concentration of free LCA include feed back inhibition of the acylCoA synthetase [5], binding to acylCoA receptors (LCA-regulated molecules and enzymes), binding to membranes and the activity of acylCoA hydrolases [6].",
keywords = "Acyl Coenzyme A, Animals, Carrier Proteins, Cytosol, Diazepam Binding Inhibitor, Escherichia coli, Gene Expression Regulation, Bacterial, Gene Expression Regulation, Fungal, Models, Biological, Rats, Saccharomyces cerevisiae, Sequence Homology, Amino Acid, Signal Transduction, Tissue Distribution",
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Knudsen, J, Jensen, MV, Hansen, JK, Færgeman, NJ, Neergaard, TB & Gaigg, B 1999, 'Role of acylCoA binding protein in acylCoA transport, metabolism and cell signaling', Molecular and Cellular Biochemistry, bind 192, nr. 1-2, s. 95-103.

Role of acylCoA binding protein in acylCoA transport, metabolism and cell signaling. / Knudsen, J; Jensen, M V; Hansen, J K; Færgeman, Nils J.; Neergaard, T B; Gaigg, B.

I: Molecular and Cellular Biochemistry, Bind 192, Nr. 1-2, 1999, s. 95-103.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Role of acylCoA binding protein in acylCoA transport, metabolism and cell signaling

AU - Knudsen, J

AU - Jensen, M V

AU - Hansen, J K

AU - Færgeman, Nils J.

AU - Neergaard, T B

AU - Gaigg, B

PY - 1999

Y1 - 1999

N2 - Long chain acylCoA esters (LCAs) act both as substrates and intermediates in intermediary metabolism and as regulators in various intracellular functions. AcylCoA binding protein (ACBP) binds LCAs with high affinity and is believed to play an important role in intracellular acylCoA transport and pool formation and therefore also for the function of LCAs as metabolites and regulators of cellular functions [1]. The major factors controlling the free concentration of cytosol long chain acylCoA ester (LCA) include ACBP [2], sterol carrier protein 2 (SCP2) [3] and fatty acid binding protein (FABP) [4]. Additional factors affecting the concentration of free LCA include feed back inhibition of the acylCoA synthetase [5], binding to acylCoA receptors (LCA-regulated molecules and enzymes), binding to membranes and the activity of acylCoA hydrolases [6].

AB - Long chain acylCoA esters (LCAs) act both as substrates and intermediates in intermediary metabolism and as regulators in various intracellular functions. AcylCoA binding protein (ACBP) binds LCAs with high affinity and is believed to play an important role in intracellular acylCoA transport and pool formation and therefore also for the function of LCAs as metabolites and regulators of cellular functions [1]. The major factors controlling the free concentration of cytosol long chain acylCoA ester (LCA) include ACBP [2], sterol carrier protein 2 (SCP2) [3] and fatty acid binding protein (FABP) [4]. Additional factors affecting the concentration of free LCA include feed back inhibition of the acylCoA synthetase [5], binding to acylCoA receptors (LCA-regulated molecules and enzymes), binding to membranes and the activity of acylCoA hydrolases [6].

KW - Acyl Coenzyme A

KW - Animals

KW - Carrier Proteins

KW - Cytosol

KW - Diazepam Binding Inhibitor

KW - Escherichia coli

KW - Gene Expression Regulation, Bacterial

KW - Gene Expression Regulation, Fungal

KW - Models, Biological

KW - Rats

KW - Saccharomyces cerevisiae

KW - Sequence Homology, Amino Acid

KW - Signal Transduction

KW - Tissue Distribution

M3 - Journal article

C2 - 10331663

VL - 192

SP - 95

EP - 103

JO - Molecular and Cellular Biochemistry

JF - Molecular and Cellular Biochemistry

SN - 0300-8177

IS - 1-2

ER -