Abstract
Aims: To estimate the risks of 12 types of somatic disease—alcohol-related, blood, cancer, circulatory, digestive, endocrine and metabolic, genitourinary, infectious, musculoskeletal, nervous, respiratory and skin—in individuals with parental alcohol use disorder (AUD) versus a reference population, and to estimate the risks of all-cause mortality and of death from an alcohol-related cause. Design: Matched cohort study followed-up through nation-wide health registries. Cox proportional hazards models were used to estimate hazard ratios (HRs) with 95% confidence intervals (CIs). Setting: Denmark. Participants: A total of 14 008 individuals born 1962–2003 of parents with AUD and 139 087 reference offspring randomly selected from the Danish Civil Registration System were followed from their 15th birthday and onward during 1970–2018. Follow-up time ranged between 2 423 955 and 3 208 366 person-years for somatic diseases and was 3 214 411 person-years for all-cause and alcohol-related mortality. Measurements: Information on somatic disease was obtained from the Danish National Patient Registry. Causes of death were obtained from the Danish Cause of Death Registry. Findings: Individuals of parents with AUD had a higher risk of alcohol-related diseases (HR = 2.70, 95% CI = 2.24–3.24) compared with the reference individuals. Higher HRs among individuals with parental AUD compared with reference individuals were also observed in all other somatic diseases except for cancer. All-cause mortality (HR = 1.80, 95% CI = 1.63–2.00) and alcohol-related mortality (HR = 3.28, 95% CI = 2.11–5.08) were higher among individuals of parents with AUD compared with the reference individuals. No significant differences were found in relation to the gender of either parents or offspring. Conclusions: In Denmark, parental alcohol use disorder appears to predict alcohol-related and non-alcohol-related somatic morbidity and mortality in offspring.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Addiction |
| Vol/bind | 117 |
| Udgave nummer | 4 |
| Sider (fra-til) | 905-912 |
| ISSN | 0965-2140 |
| DOI | |
| Status | Udgivet - apr. 2022 |
Bibliografisk note
Funding Information:This study was funded by Innovation Fund Denmark grant number 603‐00520B. The funding sources had no role in the design and conduct of the study; collection, management, analysis and interpretation of the data; preparation, review or approval of the manuscript and decision to submit the manuscript for publication. The researchers were independent from the funder, and all authors had full access to all the data (including statistical reports and tables) in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Publisher Copyright:
© 2021 Society for the Study of Addiction
Finansiering
This study was funded by Innovation Fund Denmark grant number 603‐00520B. The funding sources had no role in the design and conduct of the study; collection, management, analysis and interpretation of the data; preparation, review or approval of the manuscript and decision to submit the manuscript for publication. The researchers were independent from the funder, and all authors had full access to all the data (including statistical reports and tables) in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
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