Risk of Malignancy in FDG-Avid Thyroid Incidentalomas on PET/CT

A Prospective Study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

BACKGROUND: Due to a substantial risk of malignancy, patients with focal FDG-avid thyroid incidentalomas (FFTIs) on PET/CT are in most of Denmark referred to Head and Neck Cancer (HNC) fast track programs. The aim of this study was to determine the risk of malignancy in FFTI managed in a HNC fast track program.

METHODS: A prospective cohort study including all patients with FFTI referred to the HNC fast track program, Odense University Hospital between September 1, 2016 and August 31, 2017. Ultrasonography (US) and fine-needle aspiration biopsy (FNAB) were intended to be done in all patients. Nodules with cytology of Bethesda 1, 3, 4, 5, or 6 were planned for surgical removal.

RESULTS: A total of 104 patients were included. All patients had US and 101 patients (97%) had FNAB. Forty-two patients had benign cytology classified as Bethesda 2. The remaining 62 patients underwent surgery except from 11 patients, mainly due to comorbidity. The overall risk of malignancy for patients with FFTI referred to our HNC fast track program was calculated to be 24% (23/95) based on patients with unequivocal cytology and/or histology. The only statistically significant US characteristic to predict malignancy was the appearance of irregular margins with a sensitivity of 47% and specificity of 96%.

CONCLUSION: The risk of malignancy of FFTIs handled in our HNC fast track program is 24%.

OriginalsprogEngelsk
TidsskriftWorld Journal of Surgery
Vol/bind43
Udgave nummer10
Sider (fra-til)2454-2458
ISSN0364-2313
DOI
StatusUdgivet - okt. 2019

Fingeraftryk

Prospective Studies
Head and Neck Neoplasms
Neoplasms
Cell Biology
Ultrasonography
Denmark
Comorbidity
Cohort Studies

Citer dette

@article{a6ccc3604d054e6f8aa0ec86596c9f63,
title = "Risk of Malignancy in FDG-Avid Thyroid Incidentalomas on PET/CT: A Prospective Study",
abstract = "BACKGROUND: Due to a substantial risk of malignancy, patients with focal FDG-avid thyroid incidentalomas (FFTIs) on PET/CT are in most of Denmark referred to Head and Neck Cancer (HNC) fast track programs. The aim of this study was to determine the risk of malignancy in FFTI managed in a HNC fast track program.METHODS: A prospective cohort study including all patients with FFTI referred to the HNC fast track program, Odense University Hospital between September 1, 2016 and August 31, 2017. Ultrasonography (US) and fine-needle aspiration biopsy (FNAB) were intended to be done in all patients. Nodules with cytology of Bethesda 1, 3, 4, 5, or 6 were planned for surgical removal.RESULTS: A total of 104 patients were included. All patients had US and 101 patients (97{\%}) had FNAB. Forty-two patients had benign cytology classified as Bethesda 2. The remaining 62 patients underwent surgery except from 11 patients, mainly due to comorbidity. The overall risk of malignancy for patients with FFTI referred to our HNC fast track program was calculated to be 24{\%} (23/95) based on patients with unequivocal cytology and/or histology. The only statistically significant US characteristic to predict malignancy was the appearance of irregular margins with a sensitivity of 47{\%} and specificity of 96{\%}.CONCLUSION: The risk of malignancy of FFTIs handled in our HNC fast track program is 24{\%}.",
author = "Abdel-Halim, {Chadi Nimeh} and Tine Rosenberg and Kristine Bj{\o}rndal and Madsen, {Anders R{\o}rb{\ae}k} and John Jakobsen and Helle D{\o}ssing and Mette Bay and Anders Thomassen and Nielsen, {Anne Lerberg} and Christian Godballe",
year = "2019",
month = "10",
doi = "10.1007/s00268-019-05043-6",
language = "English",
volume = "43",
pages = "2454--2458",
journal = "World Journal of Surgery",
issn = "0364-2313",
publisher = "Springer",
number = "10",

}

TY - JOUR

T1 - Risk of Malignancy in FDG-Avid Thyroid Incidentalomas on PET/CT

T2 - A Prospective Study

AU - Abdel-Halim, Chadi Nimeh

AU - Rosenberg, Tine

AU - Bjørndal, Kristine

AU - Madsen, Anders Rørbæk

AU - Jakobsen, John

AU - Døssing, Helle

AU - Bay, Mette

AU - Thomassen, Anders

AU - Nielsen, Anne Lerberg

AU - Godballe, Christian

PY - 2019/10

Y1 - 2019/10

N2 - BACKGROUND: Due to a substantial risk of malignancy, patients with focal FDG-avid thyroid incidentalomas (FFTIs) on PET/CT are in most of Denmark referred to Head and Neck Cancer (HNC) fast track programs. The aim of this study was to determine the risk of malignancy in FFTI managed in a HNC fast track program.METHODS: A prospective cohort study including all patients with FFTI referred to the HNC fast track program, Odense University Hospital between September 1, 2016 and August 31, 2017. Ultrasonography (US) and fine-needle aspiration biopsy (FNAB) were intended to be done in all patients. Nodules with cytology of Bethesda 1, 3, 4, 5, or 6 were planned for surgical removal.RESULTS: A total of 104 patients were included. All patients had US and 101 patients (97%) had FNAB. Forty-two patients had benign cytology classified as Bethesda 2. The remaining 62 patients underwent surgery except from 11 patients, mainly due to comorbidity. The overall risk of malignancy for patients with FFTI referred to our HNC fast track program was calculated to be 24% (23/95) based on patients with unequivocal cytology and/or histology. The only statistically significant US characteristic to predict malignancy was the appearance of irregular margins with a sensitivity of 47% and specificity of 96%.CONCLUSION: The risk of malignancy of FFTIs handled in our HNC fast track program is 24%.

AB - BACKGROUND: Due to a substantial risk of malignancy, patients with focal FDG-avid thyroid incidentalomas (FFTIs) on PET/CT are in most of Denmark referred to Head and Neck Cancer (HNC) fast track programs. The aim of this study was to determine the risk of malignancy in FFTI managed in a HNC fast track program.METHODS: A prospective cohort study including all patients with FFTI referred to the HNC fast track program, Odense University Hospital between September 1, 2016 and August 31, 2017. Ultrasonography (US) and fine-needle aspiration biopsy (FNAB) were intended to be done in all patients. Nodules with cytology of Bethesda 1, 3, 4, 5, or 6 were planned for surgical removal.RESULTS: A total of 104 patients were included. All patients had US and 101 patients (97%) had FNAB. Forty-two patients had benign cytology classified as Bethesda 2. The remaining 62 patients underwent surgery except from 11 patients, mainly due to comorbidity. The overall risk of malignancy for patients with FFTI referred to our HNC fast track program was calculated to be 24% (23/95) based on patients with unequivocal cytology and/or histology. The only statistically significant US characteristic to predict malignancy was the appearance of irregular margins with a sensitivity of 47% and specificity of 96%.CONCLUSION: The risk of malignancy of FFTIs handled in our HNC fast track program is 24%.

U2 - 10.1007/s00268-019-05043-6

DO - 10.1007/s00268-019-05043-6

M3 - Journal article

VL - 43

SP - 2454

EP - 2458

JO - World Journal of Surgery

JF - World Journal of Surgery

SN - 0364-2313

IS - 10

ER -