TY - JOUR
T1 - Risk of disability pension for patients diagnosed with haematological malignancies
T2 - a register-based cohort study
AU - Horsboel, Trine A
AU - Nielsen, Claus V.
AU - Andersen, Niels T
AU - Nielsen, Bendt
AU - de Thurah, Annette
PY - 2014/6
Y1 - 2014/6
N2 - UNLABELLED: Patients with haematological malignancies are at increased risk of experiencing work-related problems. The aims of this study were to compare the risk of disability pension (DP) among patients diagnosed with eight subtypes of haematological malignancies to a reference cohort, and to determine if relative risks differ between these subtypes; to evaluate the influence of socioeconomic factors, demographic factors, and clinical factors on the risk of DP; and to investigate if these associations differ between the reference cohort and the patient cohort.MATERIAL AND METHODS: We combined data from national registers on Danish patients diagnosed with haematological malignancies between 2000 and 2007 and a reference cohort without a history of these diseases. A total of 3194 patients and 28 627 reference individuals were followed until DP, emigration, old age pension or anticipatory pension, death or 26 February 2012, whichever came first.RESULTS: A total of 550 (17%) patients and 1511 (5%) reference individuals were granted DP. Age- and gender-adjusted relative risks differed significantly between the subgroups of haematological malignancies and ranged from 2.64 (95% CI 1.84-3.78) for patients with Hodgkin lymphoma to 12.53 (95% CI 10.57-14.85) for patients with multiple myeloma. In the patient cohort we found that gender, age, comorbidity, ethnicity, educational level, household income, history of long-term sick leave, and need of treatment with anxiolytics or antidepressants after diagnosis were associated with receiving DP. However, most of these associations were stronger in the reference cohort.CONCLUSION: All eight subtypes of haematological malignancies were associated with an increased risk of DP compared to the reference cohort. The relative risks differed according to subtype, and patients with multiple myeloma had the highest risk of DP. Furthermore, most socioeconomic, demographic and clinical factors had a stronger impact on the risk of DP in the reference cohort than in the patient cohort.
AB - UNLABELLED: Patients with haematological malignancies are at increased risk of experiencing work-related problems. The aims of this study were to compare the risk of disability pension (DP) among patients diagnosed with eight subtypes of haematological malignancies to a reference cohort, and to determine if relative risks differ between these subtypes; to evaluate the influence of socioeconomic factors, demographic factors, and clinical factors on the risk of DP; and to investigate if these associations differ between the reference cohort and the patient cohort.MATERIAL AND METHODS: We combined data from national registers on Danish patients diagnosed with haematological malignancies between 2000 and 2007 and a reference cohort without a history of these diseases. A total of 3194 patients and 28 627 reference individuals were followed until DP, emigration, old age pension or anticipatory pension, death or 26 February 2012, whichever came first.RESULTS: A total of 550 (17%) patients and 1511 (5%) reference individuals were granted DP. Age- and gender-adjusted relative risks differed significantly between the subgroups of haematological malignancies and ranged from 2.64 (95% CI 1.84-3.78) for patients with Hodgkin lymphoma to 12.53 (95% CI 10.57-14.85) for patients with multiple myeloma. In the patient cohort we found that gender, age, comorbidity, ethnicity, educational level, household income, history of long-term sick leave, and need of treatment with anxiolytics or antidepressants after diagnosis were associated with receiving DP. However, most of these associations were stronger in the reference cohort.CONCLUSION: All eight subtypes of haematological malignancies were associated with an increased risk of DP compared to the reference cohort. The relative risks differed according to subtype, and patients with multiple myeloma had the highest risk of DP. Furthermore, most socioeconomic, demographic and clinical factors had a stronger impact on the risk of DP in the reference cohort than in the patient cohort.
KW - Adult
KW - Age Factors
KW - Anti-Anxiety Agents/therapeutic use
KW - Antidepressive Agents/therapeutic use
KW - Anxiety/drug therapy
KW - Cohort Studies
KW - Denmark/epidemiology
KW - Depression/drug therapy
KW - Disability Evaluation
KW - Educational Status
KW - Female
KW - Hematologic Neoplasms/epidemiology
KW - Hodgkin Disease/epidemiology
KW - Humans
KW - Income/statistics & numerical data
KW - Leukemia, Lymphoid/epidemiology
KW - Leukemia, Myeloid/epidemiology
KW - Lymphoma, Follicular/epidemiology
KW - Lymphoma, Large B-Cell, Diffuse/epidemiology
KW - Male
KW - Middle Aged
KW - Multiple Myeloma/epidemiology
KW - Pensions/statistics & numerical data
KW - Registries
KW - Retirement/statistics & numerical data
KW - Retrospective Studies
KW - Risk Factors
KW - Sex Factors
KW - Sick Leave/statistics & numerical data
KW - Socioeconomic Factors
KW - Survivors/statistics & numerical data
KW - Young Adult
U2 - 10.3109/0284186X.2013.875625
DO - 10.3109/0284186X.2013.875625
M3 - Journal article
C2 - 24456498
VL - 53
SP - 724
EP - 734
JO - Acta Oncologica
JF - Acta Oncologica
SN - 0284-186X
IS - 6
ER -