Risk of childhood otitis media with focus on potentially modifiable factors: A Danish follow-up cohort study

Asbjørn Kørvel-Hanquist*, Anders Koch, Jørgen Lous, Sjurdur Frodi Olsen, Preben Homøe

*Kontaktforfatter for dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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Resumé

Introduction Otitis media is the primary cause of antibiotic prescription in children. Two-thirds of all children experience at least one episode of otitis media before the age of 7 years. The aim of this study was to characterise the attributable effect of several modifiable risk exposures on the risk of >3 episodes of otitis media at age 18 months and 7 years within a large prospective national birth cohort. Methods The study used the Danish National Birth Cohort comprising information about otitis media and risk exposures from more than 50,000 mother-child pairs from the period 1996–2002. Logistic regression models were used to estimate odds ratios for the risk factors and to calculate the population attributable fraction. Results Short time with breastfeeding, early introduction to daycare, cesarean section, and low compliance to the national vaccination program were all associated with an increased risk of >3 episodes of otitis media at 18 months of age and at 7 years of age. The fraction of children with otitis media attributed from breastfeeding lasting for less than 6 months was 10%. Introduction to daycare before the age of 12 months attributed with 20% of the cases of >3 episodes of otitis media. Conclusions Short duration of breastfeeding, early introduction into daycare, cesarean section, and low compliance with the national vaccination program increased the risk of experiencing >3 episodes of otitis media at 18 months, and at 7 years of age. These are factors that all can be modulated.

OriginalsprogEngelsk
TidsskriftInternational Journal of Pediatric Otorhinolaryngology
Vol/bind106
Sider (fra-til)1-9
ISSN0165-5876
DOI
StatusUdgivet - mar. 2018

Fingeraftryk

Otitis Media
Cohort Studies
Logistic Models
Prescriptions
Odds Ratio
Mothers
Population

Citer dette

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title = "Risk of childhood otitis media with focus on potentially modifiable factors: A Danish follow-up cohort study",
abstract = "Introduction Otitis media is the primary cause of antibiotic prescription in children. Two-thirds of all children experience at least one episode of otitis media before the age of 7 years. The aim of this study was to characterise the attributable effect of several modifiable risk exposures on the risk of >3 episodes of otitis media at age 18 months and 7 years within a large prospective national birth cohort. Methods The study used the Danish National Birth Cohort comprising information about otitis media and risk exposures from more than 50,000 mother-child pairs from the period 1996–2002. Logistic regression models were used to estimate odds ratios for the risk factors and to calculate the population attributable fraction. Results Short time with breastfeeding, early introduction to daycare, cesarean section, and low compliance to the national vaccination program were all associated with an increased risk of >3 episodes of otitis media at 18 months of age and at 7 years of age. The fraction of children with otitis media attributed from breastfeeding lasting for less than 6 months was 10{\%}. Introduction to daycare before the age of 12 months attributed with 20{\%} of the cases of >3 episodes of otitis media. Conclusions Short duration of breastfeeding, early introduction into daycare, cesarean section, and low compliance with the national vaccination program increased the risk of experiencing >3 episodes of otitis media at 18 months, and at 7 years of age. These are factors that all can be modulated.",
keywords = "Child, Child, Preschool, Cohort Studies, Denmark/epidemiology, Female, Follow-Up Studies, Humans, Infant, Logistic Models, Male, Odds Ratio, Otitis Media/epidemiology, Pregnancy, Prospective Studies, Risk Factors",
author = "Asbj{\o}rn K{\o}rvel-Hanquist and Anders Koch and J{\o}rgen Lous and Olsen, {Sjurdur Frodi} and Preben Hom{\o}e",
year = "2018",
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language = "English",
volume = "106",
pages = "1--9",
journal = "International Journal of Pediatric Otorhinolaryngology",
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Risk of childhood otitis media with focus on potentially modifiable factors : A Danish follow-up cohort study. / Kørvel-Hanquist, Asbjørn; Koch, Anders; Lous, Jørgen; Olsen, Sjurdur Frodi; Homøe, Preben.

I: International Journal of Pediatric Otorhinolaryngology, Bind 106, 03.2018, s. 1-9.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Risk of childhood otitis media with focus on potentially modifiable factors

T2 - A Danish follow-up cohort study

AU - Kørvel-Hanquist, Asbjørn

AU - Koch, Anders

AU - Lous, Jørgen

AU - Olsen, Sjurdur Frodi

AU - Homøe, Preben

PY - 2018/3

Y1 - 2018/3

N2 - Introduction Otitis media is the primary cause of antibiotic prescription in children. Two-thirds of all children experience at least one episode of otitis media before the age of 7 years. The aim of this study was to characterise the attributable effect of several modifiable risk exposures on the risk of >3 episodes of otitis media at age 18 months and 7 years within a large prospective national birth cohort. Methods The study used the Danish National Birth Cohort comprising information about otitis media and risk exposures from more than 50,000 mother-child pairs from the period 1996–2002. Logistic regression models were used to estimate odds ratios for the risk factors and to calculate the population attributable fraction. Results Short time with breastfeeding, early introduction to daycare, cesarean section, and low compliance to the national vaccination program were all associated with an increased risk of >3 episodes of otitis media at 18 months of age and at 7 years of age. The fraction of children with otitis media attributed from breastfeeding lasting for less than 6 months was 10%. Introduction to daycare before the age of 12 months attributed with 20% of the cases of >3 episodes of otitis media. Conclusions Short duration of breastfeeding, early introduction into daycare, cesarean section, and low compliance with the national vaccination program increased the risk of experiencing >3 episodes of otitis media at 18 months, and at 7 years of age. These are factors that all can be modulated.

AB - Introduction Otitis media is the primary cause of antibiotic prescription in children. Two-thirds of all children experience at least one episode of otitis media before the age of 7 years. The aim of this study was to characterise the attributable effect of several modifiable risk exposures on the risk of >3 episodes of otitis media at age 18 months and 7 years within a large prospective national birth cohort. Methods The study used the Danish National Birth Cohort comprising information about otitis media and risk exposures from more than 50,000 mother-child pairs from the period 1996–2002. Logistic regression models were used to estimate odds ratios for the risk factors and to calculate the population attributable fraction. Results Short time with breastfeeding, early introduction to daycare, cesarean section, and low compliance to the national vaccination program were all associated with an increased risk of >3 episodes of otitis media at 18 months of age and at 7 years of age. The fraction of children with otitis media attributed from breastfeeding lasting for less than 6 months was 10%. Introduction to daycare before the age of 12 months attributed with 20% of the cases of >3 episodes of otitis media. Conclusions Short duration of breastfeeding, early introduction into daycare, cesarean section, and low compliance with the national vaccination program increased the risk of experiencing >3 episodes of otitis media at 18 months, and at 7 years of age. These are factors that all can be modulated.

KW - Child

KW - Child, Preschool

KW - Cohort Studies

KW - Denmark/epidemiology

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Infant

KW - Logistic Models

KW - Male

KW - Odds Ratio

KW - Otitis Media/epidemiology

KW - Pregnancy

KW - Prospective Studies

KW - Risk Factors

U2 - 10.1016/j.ijporl.2017.12.027

DO - 10.1016/j.ijporl.2017.12.027

M3 - Journal article

C2 - 29447878

AN - SCOPUS:85039938495

VL - 106

SP - 1

EP - 9

JO - International Journal of Pediatric Otorhinolaryngology

JF - International Journal of Pediatric Otorhinolaryngology

SN - 0165-5876

ER -