TY - JOUR
T1 - Risk of cerebrovascular events in persons with and without HIV: A Danish nationwide population-based cohort study
AU - Rasmussen, Line D
AU - Engsig, Frederik Neess
AU - Christensen, Hanne
AU - Gerstoft, Jan
AU - Kronborg, Gitte
AU - Pedersen, Court
AU - Obel, Niels
PY - 2011/6/3
Y1 - 2011/6/3
N2 - OBJECTIVE:: To assess the risk of cerebrovascular events (CVE) in HIV-infected individuals and evaluate the impact of proven risk factors, injection drug abuse (IDU), immunodeficiency, highly active antiretroviral therapy (HAART) and family-related risk factors. DESIGN:: Nationwide, population-based cohort study METHODS:: The study population included all Danish HIV-infected individuals, a population based comparison cohort and parents of both cohorts - all with no prior cerebral comorbidity. We computed incidence rate ratios (IRR) of overall CVE and CVE with and without proven risk factors, stratifying the analyses on IDU. Impact of immunodeficiency, HAART, protease-inhibitors, indinavir, didanosin, tenofovir and abacavir on risk of CVE was analyzed using time-dependent Cox regression analyses. RESULTS:: HIV-infected individuals had an increased risk of CVE compared with the comparison cohorts {(non-IDU HIV adjusted IRR 1.60; 95% CI: 1.32-1.94), (IDU HIV adjusted IRR 3.94; 95% CI: 2.16-7.16)}. The risk was increased with and without proven risk factors. A CD4 count
AB - OBJECTIVE:: To assess the risk of cerebrovascular events (CVE) in HIV-infected individuals and evaluate the impact of proven risk factors, injection drug abuse (IDU), immunodeficiency, highly active antiretroviral therapy (HAART) and family-related risk factors. DESIGN:: Nationwide, population-based cohort study METHODS:: The study population included all Danish HIV-infected individuals, a population based comparison cohort and parents of both cohorts - all with no prior cerebral comorbidity. We computed incidence rate ratios (IRR) of overall CVE and CVE with and without proven risk factors, stratifying the analyses on IDU. Impact of immunodeficiency, HAART, protease-inhibitors, indinavir, didanosin, tenofovir and abacavir on risk of CVE was analyzed using time-dependent Cox regression analyses. RESULTS:: HIV-infected individuals had an increased risk of CVE compared with the comparison cohorts {(non-IDU HIV adjusted IRR 1.60; 95% CI: 1.32-1.94), (IDU HIV adjusted IRR 3.94; 95% CI: 2.16-7.16)}. The risk was increased with and without proven risk factors. A CD4 count
U2 - 10.1097/QAD.0b013e3283493fb0
DO - 10.1097/QAD.0b013e3283493fb0
M3 - Journal article
C2 - 21646903
VL - 25
SP - 1637
EP - 1646
JO - AIDS
JF - AIDS
SN - 0269-9370
IS - 13
ER -