Risk of cancer after blood transfusion from donors with subclinical cancer: a retrospective cohort study

Gustaf Edgren, Henrik Hjalgrim, Marie Reilly, Trung Nam Tran, Klaus Rostgaard, Agneta Shanwell, Kjell Titlestad, Johanna Adami, Agneta Wikman, Casper Jersild, Gloria Gridley, Louise Wideroff, Olof Nyrén, Mads Melbye

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

BACKGROUND: Although mechanisms for detection of short-term complications after blood transfusions are well developed, complications with delayed onset, notably transmission of chronic diseases such as cancer, have been difficult to assess. Our aim was to investigate the possible risk of cancer transmission from blood donors to recipients through blood transfusion. METHODS: We did a register-based retrospective cohort study of cancer incidence among patients who received blood from donors deemed to have a subclinical cancer at the time of donation. These precancerous donors were diagnosed with a cancer within 5 years of the donation. Data from all computerised blood bank registers in Sweden and Denmark gathered between 1968 and 2002 were merged into a common database. Demographic and medical data, including mortality and cancer incidence, were ascertained through linkages with nationwide, and essentially complete, population and health-care registers. The risk of cancer in exposed recipients relative to that in recipients who received blood from non-cancerous donors was estimated with multivariate Poisson regression, adjusting for potential confounding factors. FINDINGS: Of the 354 094 transfusion recipients eligible for this analysis, 12,012 (3%) were exposed to blood products from precancerous donors. There was no excess risk of cancer overall (adjusted relative risk 1.00, 95% CI 0.94-1.07) or in crude anatomical subsites among recipients of blood from precancerous donors compared with recipients of blood from non-cancerous donors. INTERPRETATION: Our data provide no evidence that blood transfusions from precancerous blood donors are associated with increased risk of cancer among recipients compared with transfusions from non-cancerous donors
Udgivelsesdato: 2007-May-19
OriginalsprogEngelsk
TidsskriftLancet
Vol/bind369
Udgave nummer9574
Sider (fra-til)1724-30
Antal sider7
ISSN0140-6736
DOI
StatusUdgivet - 19. maj 2007

Citer dette

Edgren, G., Hjalgrim, H., Reilly, M., Tran, T. N., Rostgaard, K., Shanwell, A., ... Melbye, M. (2007). Risk of cancer after blood transfusion from donors with subclinical cancer: a retrospective cohort study. Lancet, 369(9574), 1724-30. https://doi.org/10.1016/S0140-6736(07)60779-X
Edgren, Gustaf ; Hjalgrim, Henrik ; Reilly, Marie ; Tran, Trung Nam ; Rostgaard, Klaus ; Shanwell, Agneta ; Titlestad, Kjell ; Adami, Johanna ; Wikman, Agneta ; Jersild, Casper ; Gridley, Gloria ; Wideroff, Louise ; Nyrén, Olof ; Melbye, Mads. / Risk of cancer after blood transfusion from donors with subclinical cancer: a retrospective cohort study. I: Lancet. 2007 ; Bind 369, Nr. 9574. s. 1724-30.
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title = "Risk of cancer after blood transfusion from donors with subclinical cancer: a retrospective cohort study",
abstract = "BACKGROUND: Although mechanisms for detection of short-term complications after blood transfusions are well developed, complications with delayed onset, notably transmission of chronic diseases such as cancer, have been difficult to assess. Our aim was to investigate the possible risk of cancer transmission from blood donors to recipients through blood transfusion. METHODS: We did a register-based retrospective cohort study of cancer incidence among patients who received blood from donors deemed to have a subclinical cancer at the time of donation. These precancerous donors were diagnosed with a cancer within 5 years of the donation. Data from all computerised blood bank registers in Sweden and Denmark gathered between 1968 and 2002 were merged into a common database. Demographic and medical data, including mortality and cancer incidence, were ascertained through linkages with nationwide, and essentially complete, population and health-care registers. The risk of cancer in exposed recipients relative to that in recipients who received blood from non-cancerous donors was estimated with multivariate Poisson regression, adjusting for potential confounding factors. FINDINGS: Of the 354 094 transfusion recipients eligible for this analysis, 12,012 (3{\%}) were exposed to blood products from precancerous donors. There was no excess risk of cancer overall (adjusted relative risk 1.00, 95{\%} CI 0.94-1.07) or in crude anatomical subsites among recipients of blood from precancerous donors compared with recipients of blood from non-cancerous donors. INTERPRETATION: Our data provide no evidence that blood transfusions from precancerous blood donors are associated with increased risk of cancer among recipients compared with transfusions from non-cancerous donors Udgivelsesdato: 2007-May-19",
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author = "Gustaf Edgren and Henrik Hjalgrim and Marie Reilly and Tran, {Trung Nam} and Klaus Rostgaard and Agneta Shanwell and Kjell Titlestad and Johanna Adami and Agneta Wikman and Casper Jersild and Gloria Gridley and Louise Wideroff and Olof Nyr{\'e}n and Mads Melbye",
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Edgren, G, Hjalgrim, H, Reilly, M, Tran, TN, Rostgaard, K, Shanwell, A, Titlestad, K, Adami, J, Wikman, A, Jersild, C, Gridley, G, Wideroff, L, Nyrén, O & Melbye, M 2007, 'Risk of cancer after blood transfusion from donors with subclinical cancer: a retrospective cohort study', Lancet, bind 369, nr. 9574, s. 1724-30. https://doi.org/10.1016/S0140-6736(07)60779-X

Risk of cancer after blood transfusion from donors with subclinical cancer: a retrospective cohort study. / Edgren, Gustaf; Hjalgrim, Henrik; Reilly, Marie; Tran, Trung Nam; Rostgaard, Klaus; Shanwell, Agneta; Titlestad, Kjell; Adami, Johanna; Wikman, Agneta; Jersild, Casper; Gridley, Gloria; Wideroff, Louise; Nyrén, Olof; Melbye, Mads.

I: Lancet, Bind 369, Nr. 9574, 19.05.2007, s. 1724-30.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Risk of cancer after blood transfusion from donors with subclinical cancer: a retrospective cohort study

AU - Edgren, Gustaf

AU - Hjalgrim, Henrik

AU - Reilly, Marie

AU - Tran, Trung Nam

AU - Rostgaard, Klaus

AU - Shanwell, Agneta

AU - Titlestad, Kjell

AU - Adami, Johanna

AU - Wikman, Agneta

AU - Jersild, Casper

AU - Gridley, Gloria

AU - Wideroff, Louise

AU - Nyrén, Olof

AU - Melbye, Mads

PY - 2007/5/19

Y1 - 2007/5/19

N2 - BACKGROUND: Although mechanisms for detection of short-term complications after blood transfusions are well developed, complications with delayed onset, notably transmission of chronic diseases such as cancer, have been difficult to assess. Our aim was to investigate the possible risk of cancer transmission from blood donors to recipients through blood transfusion. METHODS: We did a register-based retrospective cohort study of cancer incidence among patients who received blood from donors deemed to have a subclinical cancer at the time of donation. These precancerous donors were diagnosed with a cancer within 5 years of the donation. Data from all computerised blood bank registers in Sweden and Denmark gathered between 1968 and 2002 were merged into a common database. Demographic and medical data, including mortality and cancer incidence, were ascertained through linkages with nationwide, and essentially complete, population and health-care registers. The risk of cancer in exposed recipients relative to that in recipients who received blood from non-cancerous donors was estimated with multivariate Poisson regression, adjusting for potential confounding factors. FINDINGS: Of the 354 094 transfusion recipients eligible for this analysis, 12,012 (3%) were exposed to blood products from precancerous donors. There was no excess risk of cancer overall (adjusted relative risk 1.00, 95% CI 0.94-1.07) or in crude anatomical subsites among recipients of blood from precancerous donors compared with recipients of blood from non-cancerous donors. INTERPRETATION: Our data provide no evidence that blood transfusions from precancerous blood donors are associated with increased risk of cancer among recipients compared with transfusions from non-cancerous donors Udgivelsesdato: 2007-May-19

AB - BACKGROUND: Although mechanisms for detection of short-term complications after blood transfusions are well developed, complications with delayed onset, notably transmission of chronic diseases such as cancer, have been difficult to assess. Our aim was to investigate the possible risk of cancer transmission from blood donors to recipients through blood transfusion. METHODS: We did a register-based retrospective cohort study of cancer incidence among patients who received blood from donors deemed to have a subclinical cancer at the time of donation. These precancerous donors were diagnosed with a cancer within 5 years of the donation. Data from all computerised blood bank registers in Sweden and Denmark gathered between 1968 and 2002 were merged into a common database. Demographic and medical data, including mortality and cancer incidence, were ascertained through linkages with nationwide, and essentially complete, population and health-care registers. The risk of cancer in exposed recipients relative to that in recipients who received blood from non-cancerous donors was estimated with multivariate Poisson regression, adjusting for potential confounding factors. FINDINGS: Of the 354 094 transfusion recipients eligible for this analysis, 12,012 (3%) were exposed to blood products from precancerous donors. There was no excess risk of cancer overall (adjusted relative risk 1.00, 95% CI 0.94-1.07) or in crude anatomical subsites among recipients of blood from precancerous donors compared with recipients of blood from non-cancerous donors. INTERPRETATION: Our data provide no evidence that blood transfusions from precancerous blood donors are associated with increased risk of cancer among recipients compared with transfusions from non-cancerous donors Udgivelsesdato: 2007-May-19

KW - Blood Transfusion

KW - Cohort Studies

KW - Denmark

KW - Female

KW - Humans

KW - Male

KW - Neoplasms

KW - Registries

KW - Retrospective Studies

KW - Risk Factors

KW - Sweden

U2 - 10.1016/S0140-6736(07)60779-X

DO - 10.1016/S0140-6736(07)60779-X

M3 - Journal article

C2 - 17512857

VL - 369

SP - 1724

EP - 1730

JO - Lancet

JF - Lancet

SN - 0140-6736

IS - 9574

ER -

Edgren G, Hjalgrim H, Reilly M, Tran TN, Rostgaard K, Shanwell A et al. Risk of cancer after blood transfusion from donors with subclinical cancer: a retrospective cohort study. Lancet. 2007 maj 19;369(9574):1724-30. https://doi.org/10.1016/S0140-6736(07)60779-X