Risk of asthma in adult twins with type 2 diabetes and increased body mass index

Simon Francis Thomsen, D L Duffy, K O Kyvik, A Skytthe, Vibeke Backer

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Aim: To examine the relationship between asthma, type 2 diabetes and increased body mass index (BMI) in adult twins.
Methods: We performed record linkage between questionnaire-defined asthma and BMI, and hospital discharge diagnoses of type 2 diabetes in 34,782 Danish twins, 20-71years of age.
Results: The risk of asthma was increased in subjects with type 2 diabetes relative to nondiabetic subjects both in men (13.5%vs 7.5%), P=0.001 and in women (16.6%vs 9.6%), P=0.001. The result remained significant after adjustment for age, BMI, smoking, symptoms of chronic bronchitis, marital status and zygosity, men: OR=1.70 (1.07-2.70), P=0.026; women: OR=1.88 (1.24-2.85), P=0.003. In this analysis, BMI remained a highly significant predictor for asthma independently of diabetes status in women, P<0.000 but not in men, P=0.336. Significant positive genetic correlations were found between asthma and type 2 diabetes, 0.20 (0.01-0.40), P=0.047; between asthma and BMI in women, 0.15 (0.07-0.22), P<0.000; and between BMI and type 2 diabetes, 0.40 (0.29-0.43), P<0.000.
Conclusions: Asthma, type 2 diabetes and increased BMI are strongly associated in adults, particularly in women. These results suggest a common aetiology for asthma and metabolic syndrome.
OriginalsprogEngelsk
TidsskriftAllergy
Vol/bind66
Udgave nummer4
Sider (fra-til)562-8
DOI
StatusUdgivet - 2011

Fingeraftryk

Type 2 Diabetes Mellitus
Body Mass Index
Women's Rights
Chronic Bronchitis
Marital Status
Hypersensitivity
Smoking

Citer dette

Thomsen, Simon Francis ; Duffy, D L ; Kyvik, K O ; Skytthe, A ; Backer, Vibeke. / Risk of asthma in adult twins with type 2 diabetes and increased body mass index. I: Allergy. 2011 ; Bind 66, Nr. 4. s. 562-8.
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title = "Risk of asthma in adult twins with type 2 diabetes and increased body mass index",
abstract = "To cite this article: Thomsen SF, Duffy DL, Kyvik KO, Skytthe A, Backer V. Risk of asthma in adult twins with type 2 diabetes and increased body mass index. Allergy 2010; DOI: 10.1111/j.1398-9995.2010.02504.x. ABSTRACT: Aim:  To examine the relationship between asthma, type 2 diabetes and increased body mass index (BMI) in adult twins. Methods:  We performed record linkage between questionnaire-defined asthma and BMI, and hospital discharge diagnoses of type 2 diabetes in 34 782 Danish twins, 20-71 years of age. Results:  The risk of asthma was increased in subjects with type 2 diabetes relative to nondiabetic subjects both in men (13.5{\%}vs 7.5{\%}), P = 0.001 and in women (16.6{\%}vs 9.6{\%}), P = 0.001. The result remained significant after adjustment for age, BMI, smoking, symptoms of chronic bronchitis, marital status and zygosity, men: OR = 1.70 (1.07-2.70), P = 0.026; women: OR = 1.88 (1.24-2.85), P = 0.003. In this analysis, BMI remained a highly significant predictor for asthma independently of diabetes status in women, P ",
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Risk of asthma in adult twins with type 2 diabetes and increased body mass index. / Thomsen, Simon Francis; Duffy, D L; Kyvik, K O; Skytthe, A; Backer, Vibeke.

I: Allergy, Bind 66, Nr. 4, 2011, s. 562-8.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Risk of asthma in adult twins with type 2 diabetes and increased body mass index

AU - Thomsen, Simon Francis

AU - Duffy, D L

AU - Kyvik, K O

AU - Skytthe, A

AU - Backer, Vibeke

N1 - © 2010 John Wiley & Sons A/S.

PY - 2011

Y1 - 2011

N2 - To cite this article: Thomsen SF, Duffy DL, Kyvik KO, Skytthe A, Backer V. Risk of asthma in adult twins with type 2 diabetes and increased body mass index. Allergy 2010; DOI: 10.1111/j.1398-9995.2010.02504.x. ABSTRACT: Aim:  To examine the relationship between asthma, type 2 diabetes and increased body mass index (BMI) in adult twins. Methods:  We performed record linkage between questionnaire-defined asthma and BMI, and hospital discharge diagnoses of type 2 diabetes in 34 782 Danish twins, 20-71 years of age. Results:  The risk of asthma was increased in subjects with type 2 diabetes relative to nondiabetic subjects both in men (13.5%vs 7.5%), P = 0.001 and in women (16.6%vs 9.6%), P = 0.001. The result remained significant after adjustment for age, BMI, smoking, symptoms of chronic bronchitis, marital status and zygosity, men: OR = 1.70 (1.07-2.70), P = 0.026; women: OR = 1.88 (1.24-2.85), P = 0.003. In this analysis, BMI remained a highly significant predictor for asthma independently of diabetes status in women, P 

AB - To cite this article: Thomsen SF, Duffy DL, Kyvik KO, Skytthe A, Backer V. Risk of asthma in adult twins with type 2 diabetes and increased body mass index. Allergy 2010; DOI: 10.1111/j.1398-9995.2010.02504.x. ABSTRACT: Aim:  To examine the relationship between asthma, type 2 diabetes and increased body mass index (BMI) in adult twins. Methods:  We performed record linkage between questionnaire-defined asthma and BMI, and hospital discharge diagnoses of type 2 diabetes in 34 782 Danish twins, 20-71 years of age. Results:  The risk of asthma was increased in subjects with type 2 diabetes relative to nondiabetic subjects both in men (13.5%vs 7.5%), P = 0.001 and in women (16.6%vs 9.6%), P = 0.001. The result remained significant after adjustment for age, BMI, smoking, symptoms of chronic bronchitis, marital status and zygosity, men: OR = 1.70 (1.07-2.70), P = 0.026; women: OR = 1.88 (1.24-2.85), P = 0.003. In this analysis, BMI remained a highly significant predictor for asthma independently of diabetes status in women, P 

U2 - 10.1111/j.1398-9995.2010.02504.x

DO - 10.1111/j.1398-9995.2010.02504.x

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JO - Allergy: European Journal of Allergy and Clinical Immunology

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