Risk factors of major infections in schizophrenia

A nationwide Danish register study

M. Pankiewicz-Dulacz*, E. Stenager, M. Chen, E. N. Stenager

*Kontaktforfatter for dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Background: Risk of infections is elevated in patients with schizophrenia. Predicting their occurrence is essential, as infections in this group of patients are associated with prolonged hospital admission and increased mortality. The objective of the current investigation was to identify the potential risk factors of major infection after diagnosis with schizophrenia. Methods: This national prospective observational cohort study included 7788 people with schizophrenia born in Denmark between 1975 and 1990. Socio-demographic, psychiatric and health related data were obtained from Danish national registers. The Cox regression model was used for data analyses. Crude and adjusted hazard ratios (HRs) with 95% confidence intervals (95%CIs) are presented. Results: The most significant risk factors associated with the development of major infections included young age, female gender, medical comorbidity and substance abuse. A history of treatment with antipsychotics preceding the diagnosis was negatively associated with such morbidity. Conclusion: This study reports several factors that might increase the risk of infections in individuals with schizophrenia. Early intervention towards infections should be considered in the subpopulation of schizophrenia patients who are at increased risk of infections.

OriginalsprogEngelsk
TidsskriftJournal of Psychosomatic Research
Vol/bind121
Sider (fra-til)60-67
ISSN0022-3999
DOI
StatusUdgivet - jun. 2019

Fingeraftryk

Denmark
Proportional Hazards Models
Comorbidity
Cohort Studies
Confidence Intervals
Health

Citer dette

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title = "Risk factors of major infections in schizophrenia: A nationwide Danish register study",
abstract = "Background: Risk of infections is elevated in patients with schizophrenia. Predicting their occurrence is essential, as infections in this group of patients are associated with prolonged hospital admission and increased mortality. The objective of the current investigation was to identify the potential risk factors of major infection after diagnosis with schizophrenia. Methods: This national prospective observational cohort study included 7788 people with schizophrenia born in Denmark between 1975 and 1990. Socio-demographic, psychiatric and health related data were obtained from Danish national registers. The Cox regression model was used for data analyses. Crude and adjusted hazard ratios (HRs) with 95{\%} confidence intervals (95{\%}CIs) are presented. Results: The most significant risk factors associated with the development of major infections included young age, female gender, medical comorbidity and substance abuse. A history of treatment with antipsychotics preceding the diagnosis was negatively associated with such morbidity. Conclusion: This study reports several factors that might increase the risk of infections in individuals with schizophrenia. Early intervention towards infections should be considered in the subpopulation of schizophrenia patients who are at increased risk of infections.",
keywords = "Epidemiology, Major infections, Risk factors, Schizophrenia",
author = "M. Pankiewicz-Dulacz and E. Stenager and M. Chen and Stenager, {E. N.}",
year = "2019",
month = "6",
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Risk factors of major infections in schizophrenia : A nationwide Danish register study. / Pankiewicz-Dulacz, M.; Stenager, E. ; Chen, M.; Stenager, E. N.

I: Journal of Psychosomatic Research, Bind 121, 06.2019, s. 60-67.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Risk factors of major infections in schizophrenia

T2 - A nationwide Danish register study

AU - Pankiewicz-Dulacz, M.

AU - Stenager, E.

AU - Chen, M.

AU - Stenager, E. N.

PY - 2019/6

Y1 - 2019/6

N2 - Background: Risk of infections is elevated in patients with schizophrenia. Predicting their occurrence is essential, as infections in this group of patients are associated with prolonged hospital admission and increased mortality. The objective of the current investigation was to identify the potential risk factors of major infection after diagnosis with schizophrenia. Methods: This national prospective observational cohort study included 7788 people with schizophrenia born in Denmark between 1975 and 1990. Socio-demographic, psychiatric and health related data were obtained from Danish national registers. The Cox regression model was used for data analyses. Crude and adjusted hazard ratios (HRs) with 95% confidence intervals (95%CIs) are presented. Results: The most significant risk factors associated with the development of major infections included young age, female gender, medical comorbidity and substance abuse. A history of treatment with antipsychotics preceding the diagnosis was negatively associated with such morbidity. Conclusion: This study reports several factors that might increase the risk of infections in individuals with schizophrenia. Early intervention towards infections should be considered in the subpopulation of schizophrenia patients who are at increased risk of infections.

AB - Background: Risk of infections is elevated in patients with schizophrenia. Predicting their occurrence is essential, as infections in this group of patients are associated with prolonged hospital admission and increased mortality. The objective of the current investigation was to identify the potential risk factors of major infection after diagnosis with schizophrenia. Methods: This national prospective observational cohort study included 7788 people with schizophrenia born in Denmark between 1975 and 1990. Socio-demographic, psychiatric and health related data were obtained from Danish national registers. The Cox regression model was used for data analyses. Crude and adjusted hazard ratios (HRs) with 95% confidence intervals (95%CIs) are presented. Results: The most significant risk factors associated with the development of major infections included young age, female gender, medical comorbidity and substance abuse. A history of treatment with antipsychotics preceding the diagnosis was negatively associated with such morbidity. Conclusion: This study reports several factors that might increase the risk of infections in individuals with schizophrenia. Early intervention towards infections should be considered in the subpopulation of schizophrenia patients who are at increased risk of infections.

KW - Epidemiology

KW - Major infections

KW - Risk factors

KW - Schizophrenia

U2 - 10.1016/j.jpsychores.2019.04.003

DO - 10.1016/j.jpsychores.2019.04.003

M3 - Journal article

VL - 121

SP - 60

EP - 67

JO - Journal of Psychosomatic Research

JF - Journal of Psychosomatic Research

SN - 0022-3999

ER -