Risk factors for incident asthma and COPD in a cohort of young adults

Lisbet Krogh Traulsen*, Jesper Bælum, Anders Halling, Gert Thomsen, Trine Thilsing, David Lee Sherson, Torben Sigsgaard, Øyvind Omland, Tine Halsen Malling, Lars Rauff Skadhauge

*Kontaktforfatter for dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

82 Downloads (Pure)

Resumé

Introduction: The aim of the study was to describe potential shared risk factors for incident asthma and COPD in a population-based, 9-year follow-up study. Methods: From a cohort of 1191 individuals, aged 20-44, who participated in baseline survey including spirometry, bronchial challenge, and skin prick test (SPT) 742 subjects (62%) were reexamined at follow-up in 2012-2014. Results: A total of 27 incident cases of asthma and 22 cases of COPD were identified at follow-up corresponding to an incidence rate of 5.8 (95% CI 3.9-8.4) and 3.5 (2.2-5.3) per 1000 person years, respectively. Among the identified COPD cases a total of 12 were Asthma-COPD Overlap Syndrome (ACOS). Atopy defined by positive SPT was a risk factor for asthma in males (OR 7.54; 95% CI 1.24-45.90), whereas risk factors in females were nasal allergy (3.81; 1.20-12.11), FEV1<100% predicted (3.96; 1.07-14.62) and parental asthma (3.06; 1.00-9.40). Risk factors for COPD in males were bronchial hyperresponsiveness (23.13; 1.41-380.50) and FEV1<100% predicted (all male cases had FEV1<100% predicted) and in females current smoking (3.34; 1.16-9.59) and asthma at baseline (5.21; 1.48-18.34). Conclusions: No shared risk factors for incident asthma and COPD were found. Despite low power when stratifying by sex risk factors for incident asthma and COPD emphasize considerable gender differences.

OriginalsprogEngelsk
TidsskriftClinical Respiratory Journal
Vol/bind12
Udgave nummer3
Sider (fra-til)1021-1029
ISSN1752-6981
DOI
StatusUdgivet - mar. 2018

Fingeraftryk

Chronic Obstructive Pulmonary Disease
Young Adult
Sex Factors
Nose
Hypersensitivity
Smoking
Incidence
Population

Citer dette

Traulsen, Lisbet Krogh ; Bælum, Jesper ; Halling, Anders ; Thomsen, Gert ; Thilsing, Trine ; Lee Sherson, David ; Sigsgaard, Torben ; Omland, Øyvind ; Malling, Tine Halsen ; Skadhauge, Lars Rauff. / Risk factors for incident asthma and COPD in a cohort of young adults. I: Clinical Respiratory Journal. 2018 ; Bind 12, Nr. 3. s. 1021-1029.
@article{54f2f43f1425431db1f07a2420dd3d3c,
title = "Risk factors for incident asthma and COPD in a cohort of young adults",
abstract = "Introduction: The aim of the study was to describe potential shared risk factors for incident asthma and COPD in a population-based, 9-year follow-up study. Methods: From a cohort of 1191 individuals, aged 20-44, who participated in baseline survey including spirometry, bronchial challenge, and skin prick test (SPT) 742 subjects (62{\%}) were reexamined at follow-up in 2012-2014. Results: A total of 27 incident cases of asthma and 22 cases of COPD were identified at follow-up corresponding to an incidence rate of 5.8 (95{\%} CI 3.9-8.4) and 3.5 (2.2-5.3) per 1000 person years, respectively. Among the identified COPD cases a total of 12 were Asthma-COPD Overlap Syndrome (ACOS). Atopy defined by positive SPT was a risk factor for asthma in males (OR 7.54; 95{\%} CI 1.24-45.90), whereas risk factors in females were nasal allergy (3.81; 1.20-12.11), FEV1<100{\%} predicted (3.96; 1.07-14.62) and parental asthma (3.06; 1.00-9.40). Risk factors for COPD in males were bronchial hyperresponsiveness (23.13; 1.41-380.50) and FEV1<100{\%} predicted (all male cases had FEV1<100{\%} predicted) and in females current smoking (3.34; 1.16-9.59) and asthma at baseline (5.21; 1.48-18.34). Conclusions: No shared risk factors for incident asthma and COPD were found. Despite low power when stratifying by sex risk factors for incident asthma and COPD emphasize considerable gender differences.",
keywords = "Adult, Asthma/diagnosis, Comorbidity/trends, Denmark/epidemiology, Female, Follow-Up Studies, Forced Expiratory Volume, Humans, Incidence, Male, Population Surveillance/methods, Pulmonary Disease, Chronic Obstructive/diagnosis, Risk Assessment, Risk Factors, Sex Factors, Skin Tests, Spirometry, Time Factors, Vital Capacity, Young Adult, cohort study, epidemiology, asthma, risk factor, adult, COPD",
author = "Traulsen, {Lisbet Krogh} and Jesper B{\ae}lum and Anders Halling and Gert Thomsen and Trine Thilsing and {Lee Sherson}, David and Torben Sigsgaard and {\O}yvind Omland and Malling, {Tine Halsen} and Skadhauge, {Lars Rauff}",
note = "This is the peer reviewed version of the following article: Risk factors for incident asthma and COPD in a cohort of young adults, which has been published in final form at 10.1111/crj.12622. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving",
year = "2018",
month = "3",
doi = "10.1111/crj.12622",
language = "English",
volume = "12",
pages = "1021--1029",
journal = "Clinical Respiratory Journal",
issn = "1752-6981",
publisher = "Wiley-Blackwell",
number = "3",

}

Risk factors for incident asthma and COPD in a cohort of young adults. / Traulsen, Lisbet Krogh; Bælum, Jesper; Halling, Anders; Thomsen, Gert; Thilsing, Trine; Lee Sherson, David; Sigsgaard, Torben; Omland, Øyvind; Malling, Tine Halsen; Skadhauge, Lars Rauff.

I: Clinical Respiratory Journal, Bind 12, Nr. 3, 03.2018, s. 1021-1029.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Risk factors for incident asthma and COPD in a cohort of young adults

AU - Traulsen, Lisbet Krogh

AU - Bælum, Jesper

AU - Halling, Anders

AU - Thomsen, Gert

AU - Thilsing, Trine

AU - Lee Sherson, David

AU - Sigsgaard, Torben

AU - Omland, Øyvind

AU - Malling, Tine Halsen

AU - Skadhauge, Lars Rauff

N1 - This is the peer reviewed version of the following article: Risk factors for incident asthma and COPD in a cohort of young adults, which has been published in final form at 10.1111/crj.12622. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving

PY - 2018/3

Y1 - 2018/3

N2 - Introduction: The aim of the study was to describe potential shared risk factors for incident asthma and COPD in a population-based, 9-year follow-up study. Methods: From a cohort of 1191 individuals, aged 20-44, who participated in baseline survey including spirometry, bronchial challenge, and skin prick test (SPT) 742 subjects (62%) were reexamined at follow-up in 2012-2014. Results: A total of 27 incident cases of asthma and 22 cases of COPD were identified at follow-up corresponding to an incidence rate of 5.8 (95% CI 3.9-8.4) and 3.5 (2.2-5.3) per 1000 person years, respectively. Among the identified COPD cases a total of 12 were Asthma-COPD Overlap Syndrome (ACOS). Atopy defined by positive SPT was a risk factor for asthma in males (OR 7.54; 95% CI 1.24-45.90), whereas risk factors in females were nasal allergy (3.81; 1.20-12.11), FEV1<100% predicted (3.96; 1.07-14.62) and parental asthma (3.06; 1.00-9.40). Risk factors for COPD in males were bronchial hyperresponsiveness (23.13; 1.41-380.50) and FEV1<100% predicted (all male cases had FEV1<100% predicted) and in females current smoking (3.34; 1.16-9.59) and asthma at baseline (5.21; 1.48-18.34). Conclusions: No shared risk factors for incident asthma and COPD were found. Despite low power when stratifying by sex risk factors for incident asthma and COPD emphasize considerable gender differences.

AB - Introduction: The aim of the study was to describe potential shared risk factors for incident asthma and COPD in a population-based, 9-year follow-up study. Methods: From a cohort of 1191 individuals, aged 20-44, who participated in baseline survey including spirometry, bronchial challenge, and skin prick test (SPT) 742 subjects (62%) were reexamined at follow-up in 2012-2014. Results: A total of 27 incident cases of asthma and 22 cases of COPD were identified at follow-up corresponding to an incidence rate of 5.8 (95% CI 3.9-8.4) and 3.5 (2.2-5.3) per 1000 person years, respectively. Among the identified COPD cases a total of 12 were Asthma-COPD Overlap Syndrome (ACOS). Atopy defined by positive SPT was a risk factor for asthma in males (OR 7.54; 95% CI 1.24-45.90), whereas risk factors in females were nasal allergy (3.81; 1.20-12.11), FEV1<100% predicted (3.96; 1.07-14.62) and parental asthma (3.06; 1.00-9.40). Risk factors for COPD in males were bronchial hyperresponsiveness (23.13; 1.41-380.50) and FEV1<100% predicted (all male cases had FEV1<100% predicted) and in females current smoking (3.34; 1.16-9.59) and asthma at baseline (5.21; 1.48-18.34). Conclusions: No shared risk factors for incident asthma and COPD were found. Despite low power when stratifying by sex risk factors for incident asthma and COPD emphasize considerable gender differences.

KW - Adult

KW - Asthma/diagnosis

KW - Comorbidity/trends

KW - Denmark/epidemiology

KW - Female

KW - Follow-Up Studies

KW - Forced Expiratory Volume

KW - Humans

KW - Incidence

KW - Male

KW - Population Surveillance/methods

KW - Pulmonary Disease, Chronic Obstructive/diagnosis

KW - Risk Assessment

KW - Risk Factors

KW - Sex Factors

KW - Skin Tests

KW - Spirometry

KW - Time Factors

KW - Vital Capacity

KW - Young Adult

KW - cohort study

KW - epidemiology

KW - asthma

KW - risk factor

KW - adult

KW - COPD

U2 - 10.1111/crj.12622

DO - 10.1111/crj.12622

M3 - Journal article

VL - 12

SP - 1021

EP - 1029

JO - Clinical Respiratory Journal

JF - Clinical Respiratory Journal

SN - 1752-6981

IS - 3

ER -