Risici ved brug af selektive serotoningenoptagelseshæmmere til gravide

Terje Martens, Per Damkier, Poul Videbech

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Depression in pregnancy is common and may have serious consequences for the mother and foetus when untreated.
In this review, we discuss selective serotonin reuptake inhibitor (SSRI) intake in pregnancy, which has been associated with increased risk of several unwanted events. However, the evidence indicating a causal relationship between the intake of SSRI in pregnancy and most investigated outcomes is of very low certainty. Confounding by indication likely accounts for most of the observed correlations. If, for any outcomes, an increased risk exists, the number needed to harm is high, and the clinical significance is unclear.
OriginalsprogDansk
ArtikelnummerV06190338
TidsskriftUgeskrift for Laeger
Vol/bind181
ISSN0041-5782
StatusE-pub ahead of print - 2. dec. 2019

Fingeraftryk

Serotonin Uptake Inhibitors
Fetus

Citer dette

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title = "Risici ved brug af selektive serotoningenoptagelsesh{\ae}mmere til gravide",
abstract = "Depression in pregnancy is common and may have serious consequences for the mother and foetus when untreated.In this review, we discuss selective serotonin reuptake inhibitor (SSRI) intake in pregnancy, which has been associated with increased risk of several unwanted events. However, the evidence indicating a causal relationship between the intake of SSRI in pregnancy and most investigated outcomes is of very low certainty. Confounding by indication likely accounts for most of the observed correlations. If, for any outcomes, an increased risk exists, the number needed to harm is high, and the clinical significance is unclear.",
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Risici ved brug af selektive serotoningenoptagelseshæmmere til gravide. / Martens, Terje; Damkier, Per; Videbech, Poul.

I: Ugeskrift for Laeger, Bind 181, V06190338, 02.12.2019.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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AU - Martens, Terje

AU - Damkier, Per

AU - Videbech, Poul

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N2 - Depression in pregnancy is common and may have serious consequences for the mother and foetus when untreated.In this review, we discuss selective serotonin reuptake inhibitor (SSRI) intake in pregnancy, which has been associated with increased risk of several unwanted events. However, the evidence indicating a causal relationship between the intake of SSRI in pregnancy and most investigated outcomes is of very low certainty. Confounding by indication likely accounts for most of the observed correlations. If, for any outcomes, an increased risk exists, the number needed to harm is high, and the clinical significance is unclear.

AB - Depression in pregnancy is common and may have serious consequences for the mother and foetus when untreated.In this review, we discuss selective serotonin reuptake inhibitor (SSRI) intake in pregnancy, which has been associated with increased risk of several unwanted events. However, the evidence indicating a causal relationship between the intake of SSRI in pregnancy and most investigated outcomes is of very low certainty. Confounding by indication likely accounts for most of the observed correlations. If, for any outcomes, an increased risk exists, the number needed to harm is high, and the clinical significance is unclear.

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JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

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