Revascularisation of fresh compared with demineralised bone grafts in rats

E Solheim, E M Pinholt, O Talsnes, T B Larsen, O J Kirkeby

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstract

Revascularisation of bone grafts is influenced by both the anatomical origin and the pre-implantation processing of the graft. We investigated the revascularisation by entrapment of 141Ce (cerium)-labelled microspheres in large, fresh and demineralised syngeneic grafts of predominantly cancellous (iliac bone) or cortical (tibial diaphysis) bone three weeks after heterotopic implantation in rats. The mean (SD) 141Ce deposition index (counts per minute (cpm) of mg recovered implant/cpm of mg host iliac bone) was higher in fresh iliac bone grafts, 0.98 (0.46) compared to that of demineralised iliac bone, 0.32 (0.20), p <0.001, and fresh tibial bone grafts, 0.51 (0.27), p = 0.007. We found no significant difference in the mean 141Ce deposition index between fresh tibial bone grafts and demineralised tibial bone grafts, 0.35 (0.42), p = 0.4, or between demineralised tibial grafts and demineralised iliac bone grafts, p = 0.8. The results suggest that whereas fresh cancellous grafts are revascularised more completely than fresh cortical grafts, there is no difference in the revascularisation of demineralised cancellous and cortical grafts. In addition, fresh cancellous bone is revascularised more completely than demineralised cancellous bone, whereas there is no difference between fresh and demineralised cortical bone.
OriginalsprogEngelsk
TidsskriftScandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery
Vol/bind35
Udgave nummer2
Sider (fra-til)113-116
DOI
StatusUdgivet - 1. jun. 2001
Udgivet eksterntJa

Fingeraftryk

Dyk ned i forskningsemnerne om 'Revascularisation of fresh compared with demineralised bone grafts in rats'. Sammen danner de et unikt fingeraftryk.

Citationsformater