Retinopathy in severe malaria in Ghanaian children--overlap between fundus changes in cerebral and non-cerebral malaria

Vera A Essuman; Christine T Ntim-Amponsah; Birgitte Schmidt Astrup; George O Adjei; Jorgen A L Kurtzhals; Thomas A Ndanu; Bamenla Goka

doi:10.1186/1475-2875-9-232

Retinopathy in severe malaria in Ghanaian children--overlap between fundus changes in cerebral and non-cerebral malaria

Vera A Essuman
, Christine T Ntim-Amponsah
, Birgitte Schmidt Astrup
, George O Adjei
, Jorgen A L Kurtzhals
, Thomas A Ndanu
, Bamenla Goka

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Abstract

In malaria-endemic areas, reliably establishing parasitaemia for diagnosis of malaria can be difficult. A retinopathy with some features unique to severe malaria with a predictive value on prognosis, has been described. Detection of this retinopathy could be a useful diagnostic tool. This study was designed to determine the diagnostic usefulness of retinopathy on ophthalmoscopy in severe malaria syndromes: Cerebral malaria (CM) and non-cerebral severe malaria (non-CM), i.e. malaria with respiratory distress (RD) and malaria with severe anaemia (SA), in Ghanaian children. Secondly, to determine any association between retinopathy and the occurrence of convulsions in patients with CM.

Originalsprog	Engelsk
Tidsskrift	Malaria Journal
Vol/bind	9
Sider (fra-til)	232
ISSN	1475-2875
DOI	https://doi.org/10.1186/1475-2875-9-232
Status	Udgivet - 1. jan. 2010

Dokumenter og links

10.1186/1475-2875-9-232

SDU link

Tjek adgangen til materialet i Syddansk Universitetsbiblioteks søgemaskine

Citationsformater

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title = "Retinopathy in severe malaria in Ghanaian children--overlap between fundus changes in cerebral and non-cerebral malaria",

abstract = "In malaria-endemic areas, reliably establishing parasitaemia for diagnosis of malaria can be difficult. A retinopathy with some features unique to severe malaria with a predictive value on prognosis, has been described. Detection of this retinopathy could be a useful diagnostic tool. This study was designed to determine the diagnostic usefulness of retinopathy on ophthalmoscopy in severe malaria syndromes: Cerebral malaria (CM) and non-cerebral severe malaria (non-CM), i.e. malaria with respiratory distress (RD) and malaria with severe anaemia (SA), in Ghanaian children. Secondly, to determine any association between retinopathy and the occurrence of convulsions in patients with CM.",

keywords = "African Continental Ancestry Group, Antimalarials, Brain Ischemia, Child, Child, Preschool, Cross-Sectional Studies, Female, Follow-Up Studies, Ghana, Humans, Infant, Malaria, Malaria, Cerebral, Male, Ophthalmoscopy, Parasitemia, Plasmodium falciparum, Prognosis, Quinine, Retinal Diseases, Severity of Illness Index",

author = "Essuman, \{Vera A\} and Ntim-Amponsah, \{Christine T\} and Astrup, \{Birgitte Schmidt\} and Adjei, \{George O\} and Kurtzhals, \{Jorgen A L\} and Ndanu, \{Thomas A\} and Bamenla Goka",

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doi = "10.1186/1475-2875-9-232",

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TY - JOUR

T1 - Retinopathy in severe malaria in Ghanaian children--overlap between fundus changes in cerebral and non-cerebral malaria

AU - Essuman, Vera A

AU - Ntim-Amponsah, Christine T

AU - Astrup, Birgitte Schmidt

AU - Adjei, George O

AU - Kurtzhals, Jorgen A L

AU - Ndanu, Thomas A

AU - Goka, Bamenla

PY - 2010/1/1

Y1 - 2010/1/1

N2 - In malaria-endemic areas, reliably establishing parasitaemia for diagnosis of malaria can be difficult. A retinopathy with some features unique to severe malaria with a predictive value on prognosis, has been described. Detection of this retinopathy could be a useful diagnostic tool. This study was designed to determine the diagnostic usefulness of retinopathy on ophthalmoscopy in severe malaria syndromes: Cerebral malaria (CM) and non-cerebral severe malaria (non-CM), i.e. malaria with respiratory distress (RD) and malaria with severe anaemia (SA), in Ghanaian children. Secondly, to determine any association between retinopathy and the occurrence of convulsions in patients with CM.

AB - In malaria-endemic areas, reliably establishing parasitaemia for diagnosis of malaria can be difficult. A retinopathy with some features unique to severe malaria with a predictive value on prognosis, has been described. Detection of this retinopathy could be a useful diagnostic tool. This study was designed to determine the diagnostic usefulness of retinopathy on ophthalmoscopy in severe malaria syndromes: Cerebral malaria (CM) and non-cerebral severe malaria (non-CM), i.e. malaria with respiratory distress (RD) and malaria with severe anaemia (SA), in Ghanaian children. Secondly, to determine any association between retinopathy and the occurrence of convulsions in patients with CM.

KW - African Continental Ancestry Group

KW - Antimalarials

KW - Brain Ischemia

KW - Child

KW - Child, Preschool

KW - Cross-Sectional Studies

KW - Female

KW - Follow-Up Studies

KW - Ghana

KW - Humans

KW - Infant

KW - Malaria

KW - Malaria, Cerebral

KW - Male

KW - Ophthalmoscopy

KW - Parasitemia

KW - Plasmodium falciparum

KW - Prognosis

KW - Quinine

KW - Retinal Diseases

KW - Severity of Illness Index

U2 - 10.1186/1475-2875-9-232

DO - 10.1186/1475-2875-9-232

M3 - Journal article

C2 - 20704742

SN - 1475-2875

VL - 9

SP - 232

JO - Malaria Journal

JF - Malaria Journal

ER -

Retinopathy in severe malaria in Ghanaian children--overlap between fundus changes in cerebral and non-cerebral malaria

Abstract

Dokumenter og links

SDU link

Fingeraftryk

Citationsformater