Abstract
Purpose
To evaluate if retinal vascular fractal dimensions are predictive for long-term progression to proliferative diabetic retinopathy (PDR) in patients with no or minimal diabetic retinopathy (DR).
Methods
This was a register-based case-control study with 11 years of follow-up, in which we identified eyes with progression from International Clinical Diabetic Retinopathy (ICDR) level 0 or 1 to PDR (cases) and compared these to eyes without any progression of DR (controls). Every case was matched to two control patients on age, sex, type of diabetes, ICDR-level at baseline and time from first to last screening episode.
The semi-automatic software VAMPIRE (version 3.2; Vessel Assessment and Measurement Platform for Images of the Retina; The Vampire Group; Edinburgh United Kingdom) was applied for retinal image analysis.
Results
We included 38 eyes from 27 cases and 62 eyes from 49 controls. In a multivariable logistic regression model with cluster robust standard error, venular fractal dimension (vFD) (OR 2.14 per standard-deviation; 95%-CI: 1.17 to 3.94; p=0.01), triglyceride (OR 1.27 per 1 mmol/L; 95%-CI: 1.06 to 1.52; p = 0.009), serum-creatinine (OR 1.03 per 1 µmol/L; 95%-CI: 1.01 to 1-05; p=0.04) and duration of diabetes (OR 1.06 per year; 95%-CI: 1.02 to 1.11; p=0.006) were associated to increased risk of PDR progression.
Conclusions
In this case-control study with 11 years of observation time, vFD independently predicted long-term incidence of PDR along with well-known risk factors like triglyceride, serum-creatinine and duration of diabetes.
To evaluate if retinal vascular fractal dimensions are predictive for long-term progression to proliferative diabetic retinopathy (PDR) in patients with no or minimal diabetic retinopathy (DR).
Methods
This was a register-based case-control study with 11 years of follow-up, in which we identified eyes with progression from International Clinical Diabetic Retinopathy (ICDR) level 0 or 1 to PDR (cases) and compared these to eyes without any progression of DR (controls). Every case was matched to two control patients on age, sex, type of diabetes, ICDR-level at baseline and time from first to last screening episode.
The semi-automatic software VAMPIRE (version 3.2; Vessel Assessment and Measurement Platform for Images of the Retina; The Vampire Group; Edinburgh United Kingdom) was applied for retinal image analysis.
Results
We included 38 eyes from 27 cases and 62 eyes from 49 controls. In a multivariable logistic regression model with cluster robust standard error, venular fractal dimension (vFD) (OR 2.14 per standard-deviation; 95%-CI: 1.17 to 3.94; p=0.01), triglyceride (OR 1.27 per 1 mmol/L; 95%-CI: 1.06 to 1.52; p = 0.009), serum-creatinine (OR 1.03 per 1 µmol/L; 95%-CI: 1.01 to 1-05; p=0.04) and duration of diabetes (OR 1.06 per year; 95%-CI: 1.02 to 1.11; p=0.006) were associated to increased risk of PDR progression.
Conclusions
In this case-control study with 11 years of observation time, vFD independently predicted long-term incidence of PDR along with well-known risk factors like triglyceride, serum-creatinine and duration of diabetes.
| Originalsprog | Engelsk |
|---|---|
| Publikationsdato | 2023 |
| Status | Udgivet - 2023 |
| Begivenhed | Euretina 2023 - RAI Amsterdam, Amsterdam, Holland Varighed: 5. okt. 2023 → 8. okt. 2023 https://euretina.org/amsterdam-2023/information/ |
Konference
| Konference | Euretina 2023 |
|---|---|
| Lokation | RAI Amsterdam |
| Land/Område | Holland |
| By | Amsterdam |
| Periode | 05/10/2023 → 08/10/2023 |
| Internetadresse |