Early onset type 2 diabetes: Age gradient in clinical and behavioural risk factors in 5115 persons with newly diagnosed type 2 diabetes—Results from the DD2 study

Bidragets oversatte titel: Results from the DD2 study

A Bo, R W Thomsen, J S Nielsen, Sia Kromann Nicolaisen, H Beck-Nielsen, J Rungby, H T Sørensen, T K Hansen, J Søndergaard, S Friborg, T Lauritzen, H T Maindal

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Aim: To examine the association between early onset of type 2 diabetes mellitus (DM) and clinical and behavioural risk factors for later complications of diabetes. Methods: We conducted a cross-sectional study of 5115 persons with incident type 2 DM enrolled during 2010-2015 in the Danish Centre for Strategic Research in Type 2 Diabetes-cohort. We compared risk factors at time of diagnosis among those diagnosed at ≤45 years (early onset) with diagnosis age 46 to 55, 56 to 65 (average onset = reference), 66 to 75, and >75 years (late onset). Prevalence ratios (PRs) were computed by using Poisson regression. Results: Poor glucose control, ie, HbA1c ≥ 75 mmol/mol (≥9.0%) in the early-, average-, and late-onset groups was observed in 12%, 7%, and 1%, respectively (PR 1.70 [95% confidence intervals (CI) 1.27, 2.28] and PR 0.17 [95% CI 0.06, 0.45]). A similar age gradient was observed for severe obesity (body mass index > 40 kg/m 2: 19% vs. 8% vs. 2%; PR 2.41 [95% CI 1.83, 3.18] and 0.21 (95% CI 0.08, 0.57]), dyslipidemia (90% vs. 79% vs. 68%; PR 1.14 [95% CI 1.10, 1.19] and 0.86 [95% CI 0.79, 0.93]), and low-grade inflammation (C-reactive protein > 3.0 mg/L: 53% vs. 38% vs. 26%; PR 1.41 [95% CI 1.12, 1.78] and 0.68 [95% CI 0.42, 1.11]). Daily smoking was more frequent and meeting physical activity recommendations less likely in persons with early-onset type 2 DM. Conclusions: We found a clear age gradient, with increasing prevalence of clinical and behavioural risk factors the younger the onset age of type 2 DM. Younger persons with early-onset type 2 DM need clinical awareness and support.

OriginalsprogEngelsk
Artikelnummere2968
TidsskriftDiabetes - Metabolism: Research and Reviews (Print Edition)
Vol/bind34
Udgave nummer3
Antal sider9
ISSN1520-7552
DOI
StatusUdgivet - mar. 2018

Fingeraftryk

Medical problems
Type 2 Diabetes Mellitus
Confidence Intervals
Morbid Obesity
C-Reactive Protein
Diabetes Complications
Dyslipidemias
Age of Onset
Body Mass Index
Cross-Sectional Studies
Smoking
Glucose
Research

Citer dette

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title = "Early onset type 2 diabetes: Age gradient in clinical and behavioural risk factors in 5115 persons with newly diagnosed type 2 diabetes—Results from the DD2 study",
abstract = "Aim: To examine the association between early onset of type 2 diabetes mellitus (DM) and clinical and behavioural risk factors for later complications of diabetes. Methods: We conducted a cross-sectional study of 5115 persons with incident type 2 DM enrolled during 2010-2015 in the Danish Centre for Strategic Research in Type 2 Diabetes-cohort. We compared risk factors at time of diagnosis among those diagnosed at ≤45 years (early onset) with diagnosis age 46 to 55, 56 to 65 (average onset = reference), 66 to 75, and >75 years (late onset). Prevalence ratios (PRs) were computed by using Poisson regression. Results: Poor glucose control, ie, HbA1c ≥ 75 mmol/mol (≥9.0{\%}) in the early-, average-, and late-onset groups was observed in 12{\%}, 7{\%}, and 1{\%}, respectively (PR 1.70 [95{\%} confidence intervals (CI) 1.27, 2.28] and PR 0.17 [95{\%} CI 0.06, 0.45]). A similar age gradient was observed for severe obesity (body mass index > 40 kg/m 2: 19{\%} vs. 8{\%} vs. 2{\%}; PR 2.41 [95{\%} CI 1.83, 3.18] and 0.21 (95{\%} CI 0.08, 0.57]), dyslipidemia (90{\%} vs. 79{\%} vs. 68{\%}; PR 1.14 [95{\%} CI 1.10, 1.19] and 0.86 [95{\%} CI 0.79, 0.93]), and low-grade inflammation (C-reactive protein > 3.0 mg/L: 53{\%} vs. 38{\%} vs. 26{\%}; PR 1.41 [95{\%} CI 1.12, 1.78] and 0.68 [95{\%} CI 0.42, 1.11]). Daily smoking was more frequent and meeting physical activity recommendations less likely in persons with early-onset type 2 DM. Conclusions: We found a clear age gradient, with increasing prevalence of clinical and behavioural risk factors the younger the onset age of type 2 DM. Younger persons with early-onset type 2 DM need clinical awareness and support.",
keywords = "Journal Article, DD2 study, risk factors, cross sections study, early onset type 2 diabetes, health behaviour, Body Mass Index, Prognosis, Age Factors, Cross-Sectional Studies, Follow-Up Studies, Humans, Middle Aged, Risk Factors, Male, Diabetes Mellitus, Type 2/diagnosis, Age of Onset, Female, Aged",
author = "A Bo and Thomsen, {R W} and Nielsen, {J S} and Nicolaisen, {Sia Kromann} and H Beck-Nielsen and J Rungby and S{\o}rensen, {H T} and Hansen, {T K} and J S{\o}ndergaard and S Friborg and T Lauritzen and Maindal, {H T}",
note = "This article is protected by copyright. All rights reserved.",
year = "2018",
month = "3",
doi = "10.1002/dmrr.2968",
language = "English",
volume = "34",
journal = "Diabetes - Metabolism: Research and Reviews (Print Edition)",
issn = "1520-7552",
publisher = "John Wiley & Sons Ltd",
number = "3",

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Early onset type 2 diabetes : Age gradient in clinical and behavioural risk factors in 5115 persons with newly diagnosed type 2 diabetes—Results from the DD2 study. / Bo, A; Thomsen, R W; Nielsen, J S; Nicolaisen, Sia Kromann; Beck-Nielsen, H; Rungby, J; Sørensen, H T; Hansen, T K; Søndergaard, J; Friborg, S; Lauritzen, T; Maindal, H T.

I: Diabetes - Metabolism: Research and Reviews (Print Edition), Bind 34, Nr. 3, e2968, 03.2018.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Early onset type 2 diabetes

T2 - Age gradient in clinical and behavioural risk factors in 5115 persons with newly diagnosed type 2 diabetes—Results from the DD2 study

AU - Bo, A

AU - Thomsen, R W

AU - Nielsen, J S

AU - Nicolaisen, Sia Kromann

AU - Beck-Nielsen, H

AU - Rungby, J

AU - Sørensen, H T

AU - Hansen, T K

AU - Søndergaard, J

AU - Friborg, S

AU - Lauritzen, T

AU - Maindal, H T

N1 - This article is protected by copyright. All rights reserved.

PY - 2018/3

Y1 - 2018/3

N2 - Aim: To examine the association between early onset of type 2 diabetes mellitus (DM) and clinical and behavioural risk factors for later complications of diabetes. Methods: We conducted a cross-sectional study of 5115 persons with incident type 2 DM enrolled during 2010-2015 in the Danish Centre for Strategic Research in Type 2 Diabetes-cohort. We compared risk factors at time of diagnosis among those diagnosed at ≤45 years (early onset) with diagnosis age 46 to 55, 56 to 65 (average onset = reference), 66 to 75, and >75 years (late onset). Prevalence ratios (PRs) were computed by using Poisson regression. Results: Poor glucose control, ie, HbA1c ≥ 75 mmol/mol (≥9.0%) in the early-, average-, and late-onset groups was observed in 12%, 7%, and 1%, respectively (PR 1.70 [95% confidence intervals (CI) 1.27, 2.28] and PR 0.17 [95% CI 0.06, 0.45]). A similar age gradient was observed for severe obesity (body mass index > 40 kg/m 2: 19% vs. 8% vs. 2%; PR 2.41 [95% CI 1.83, 3.18] and 0.21 (95% CI 0.08, 0.57]), dyslipidemia (90% vs. 79% vs. 68%; PR 1.14 [95% CI 1.10, 1.19] and 0.86 [95% CI 0.79, 0.93]), and low-grade inflammation (C-reactive protein > 3.0 mg/L: 53% vs. 38% vs. 26%; PR 1.41 [95% CI 1.12, 1.78] and 0.68 [95% CI 0.42, 1.11]). Daily smoking was more frequent and meeting physical activity recommendations less likely in persons with early-onset type 2 DM. Conclusions: We found a clear age gradient, with increasing prevalence of clinical and behavioural risk factors the younger the onset age of type 2 DM. Younger persons with early-onset type 2 DM need clinical awareness and support.

AB - Aim: To examine the association between early onset of type 2 diabetes mellitus (DM) and clinical and behavioural risk factors for later complications of diabetes. Methods: We conducted a cross-sectional study of 5115 persons with incident type 2 DM enrolled during 2010-2015 in the Danish Centre for Strategic Research in Type 2 Diabetes-cohort. We compared risk factors at time of diagnosis among those diagnosed at ≤45 years (early onset) with diagnosis age 46 to 55, 56 to 65 (average onset = reference), 66 to 75, and >75 years (late onset). Prevalence ratios (PRs) were computed by using Poisson regression. Results: Poor glucose control, ie, HbA1c ≥ 75 mmol/mol (≥9.0%) in the early-, average-, and late-onset groups was observed in 12%, 7%, and 1%, respectively (PR 1.70 [95% confidence intervals (CI) 1.27, 2.28] and PR 0.17 [95% CI 0.06, 0.45]). A similar age gradient was observed for severe obesity (body mass index > 40 kg/m 2: 19% vs. 8% vs. 2%; PR 2.41 [95% CI 1.83, 3.18] and 0.21 (95% CI 0.08, 0.57]), dyslipidemia (90% vs. 79% vs. 68%; PR 1.14 [95% CI 1.10, 1.19] and 0.86 [95% CI 0.79, 0.93]), and low-grade inflammation (C-reactive protein > 3.0 mg/L: 53% vs. 38% vs. 26%; PR 1.41 [95% CI 1.12, 1.78] and 0.68 [95% CI 0.42, 1.11]). Daily smoking was more frequent and meeting physical activity recommendations less likely in persons with early-onset type 2 DM. Conclusions: We found a clear age gradient, with increasing prevalence of clinical and behavioural risk factors the younger the onset age of type 2 DM. Younger persons with early-onset type 2 DM need clinical awareness and support.

KW - Journal Article

KW - DD2 study

KW - risk factors

KW - cross sections study

KW - early onset type 2 diabetes

KW - health behaviour

KW - Body Mass Index

KW - Prognosis

KW - Age Factors

KW - Cross-Sectional Studies

KW - Follow-Up Studies

KW - Humans

KW - Middle Aged

KW - Risk Factors

KW - Male

KW - Diabetes Mellitus, Type 2/diagnosis

KW - Age of Onset

KW - Female

KW - Aged

U2 - 10.1002/dmrr.2968

DO - 10.1002/dmrr.2968

M3 - Journal article

C2 - 29172021

VL - 34

JO - Diabetes - Metabolism: Research and Reviews (Print Edition)

JF - Diabetes - Metabolism: Research and Reviews (Print Edition)

SN - 1520-7552

IS - 3

M1 - e2968

ER -