Vitamin D3 supplementation and treatment outcomes in patients with depression

Bidragets oversatte titel: Resultater af Add-on D3 vitamin til patienter med depression

Jens Peter Hansen, Manan Pareek, Allan Hvolby, Anne Schmedes, Tomas Toft, Erik Dahl, Connie Thurøe Nielsen

Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskningpeer review


Objective: To examine whether vitamin D supplementation in patients with depression would result in a reduction in Hamilton D-17 depression score (primary outcome) at 3 and 6 months compared to controls and to explore the correlations between serum vitamin D and symptoms of depression, wellbeing, systolic blood pressure, and waist circumference. Background: Prior evidence indicates that vitamin D supplementation might have potential benefits as an add-on treatment among patients with depression, particularly during the winter period when levels are low. However, no studies have explored the use of vitamin-D as add-on in regular depression praxis. Materials and Methods: In this outpatient multicentre study conducted between 2010 and 2013, patients, 18–65 years old, diagnosed with mild to severe depression were randomly assigned to receive D supplementation 70 micrograms daily or placebo on top of standard treatment. Participants, care givers and those assessing the outcomes were blinded to group assignment. Results and Conclusions: Results: At baseline, 23 patients had a normal 25(OH)D level, 22 had insufficiency (<25 nmol/l), and 17 had deficiency (25–50 nmol/l). No significant reduction in depression was seen after vitamin D supplementation compared to placebo at Hamilton (18.4-18.0; P=0.73 at 12 weeks). Vitamin D supplementation did not provide a reduction in symptom score among patients with depression.
Bidragets oversatte titelResultater af Add-on D3 vitamin til patienter med depression
StatusUdgivet - 2019
Begivenhed19th WPA World Congress of Psychyatry - Lisbon, Lisbon, Portugal
Varighed: 21. aug. 201924. nov. 2019
Konferencens nummer: 19


Konference19th WPA World Congress of Psychyatry