Response inhibition is associated with white matter microstructure in children

Kathrine Skak Madsen, William F C Baaré, Martin Vestergaard, Arnold Skimminge, Lisser Rye Ejersbo, Thomas Z Ramsøy, Christian Gerlach, Per Akeson, Olaf B Paulson, Terry L Jernigan

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Cognitive control of thoughts, actions and emotions is important for normal behaviour and the development of such control continues throughout childhood and adolescence. Several lines of evidence suggest that response inhibition is primarily mediated by a right-lateralized network involving inferior frontal gyrus (IFG), presupplementary motor cortex (preSMA), and subthalamic nucleus. Though the brain's fibre tracts are known to develop during childhood, little is known about how fibre tract development within this network relates to developing behavioural control. Here we examined the relationship between response inhibition, as measured with the stop-signal task, and indices of regional white matter microstructure in typically-developing children. We hypothesized that better response inhibition performance would be associated with higher fractional anisotropy (FA) in fibre tracts within right IFG and preSMA after controlling for age. Mean FA and diffusivity values were extracted from right and left IFG and preSMA. As hypothesized, faster response inhibition was significantly associated with higher FA and lower perpendicular diffusivity in both the right IFG and the right preSMA, possibly reflecting faster speed of neural conduction within more densely packed or better myelinated fibre tracts. Moreover, both of these effects remained significant after controlling for age and whole brain estimates of these DTI parameters. Interestingly, right IFG and preSMA FA contributed additively to the prediction of performance variability. Observed associations may be related to variation in phase of maturation, to activity-dependent alterations in the network subserving response inhibition, or to stable individual differences in underlying neural system connectivity.

OriginalsprogEngelsk
TidsskriftNeuropsychologia
Vol/bind48
Udgave nummer4
Sider (fra-til)854-62
Antal sider9
ISSN0028-3932
DOI
StatusUdgivet - mar. 2010

Fingeraftryk

Anisotropy
Subthalamic Nucleus
Motor Cortex
Individuality
White Matter

Citer dette

Madsen, K. S., Baaré, W. F. C., Vestergaard, M., Skimminge, A., Ejersbo, L. R., Ramsøy, T. Z., ... Jernigan, T. L. (2010). Response inhibition is associated with white matter microstructure in children. Neuropsychologia, 48(4), 854-62. https://doi.org/10.1016/j.neuropsychologia.2009.11.001
Madsen, Kathrine Skak ; Baaré, William F C ; Vestergaard, Martin ; Skimminge, Arnold ; Ejersbo, Lisser Rye ; Ramsøy, Thomas Z ; Gerlach, Christian ; Akeson, Per ; Paulson, Olaf B ; Jernigan, Terry L. / Response inhibition is associated with white matter microstructure in children. I: Neuropsychologia. 2010 ; Bind 48, Nr. 4. s. 854-62.
@article{e89c43b3389245d3aa98bfb2538a6588,
title = "Response inhibition is associated with white matter microstructure in children",
abstract = "Cognitive control of thoughts, actions and emotions is important for normal behaviour and the development of such control continues throughout childhood and adolescence. Several lines of evidence suggest that response inhibition is primarily mediated by a right-lateralized network involving inferior frontal gyrus (IFG), presupplementary motor cortex (preSMA), and subthalamic nucleus. Though the brain's fibre tracts are known to develop during childhood, little is known about how fibre tract development within this network relates to developing behavioural control. Here we examined the relationship between response inhibition, as measured with the stop-signal task, and indices of regional white matter microstructure in typically-developing children. We hypothesized that better response inhibition performance would be associated with higher fractional anisotropy (FA) in fibre tracts within right IFG and preSMA after controlling for age. Mean FA and diffusivity values were extracted from right and left IFG and preSMA. As hypothesized, faster response inhibition was significantly associated with higher FA and lower perpendicular diffusivity in both the right IFG and the right preSMA, possibly reflecting faster speed of neural conduction within more densely packed or better myelinated fibre tracts. Moreover, both of these effects remained significant after controlling for age and whole brain estimates of these DTI parameters. Interestingly, right IFG and preSMA FA contributed additively to the prediction of performance variability. Observed associations may be related to variation in phase of maturation, to activity-dependent alterations in the network subserving response inhibition, or to stable individual differences in underlying neural system connectivity.",
keywords = "Adolescent, Age Factors, Brain, Child, Female, Frontal Lobe, Functional Laterality, Humans, Image Processing, Computer-Assisted, Inhibition (Psychology), Linear Models, Magnetic Resonance Imaging, Male, Motor Cortex, Neural Pathways, Neuropsychological Tests, Psychomotor Performance, Reaction Time",
author = "Madsen, {Kathrine Skak} and Baar{\'e}, {William F C} and Martin Vestergaard and Arnold Skimminge and Ejersbo, {Lisser Rye} and Rams{\o}y, {Thomas Z} and Christian Gerlach and Per Akeson and Paulson, {Olaf B} and Jernigan, {Terry L}",
note = "Copyright (c) 2009 Elsevier Ltd. All rights reserved.",
year = "2010",
month = "3",
doi = "10.1016/j.neuropsychologia.2009.11.001",
language = "English",
volume = "48",
pages = "854--62",
journal = "Neuropsychologia",
issn = "0028-3932",
publisher = "Pergamon Press",
number = "4",

}

Madsen, KS, Baaré, WFC, Vestergaard, M, Skimminge, A, Ejersbo, LR, Ramsøy, TZ, Gerlach, C, Akeson, P, Paulson, OB & Jernigan, TL 2010, 'Response inhibition is associated with white matter microstructure in children', Neuropsychologia, bind 48, nr. 4, s. 854-62. https://doi.org/10.1016/j.neuropsychologia.2009.11.001

Response inhibition is associated with white matter microstructure in children. / Madsen, Kathrine Skak; Baaré, William F C; Vestergaard, Martin; Skimminge, Arnold; Ejersbo, Lisser Rye; Ramsøy, Thomas Z; Gerlach, Christian; Akeson, Per; Paulson, Olaf B; Jernigan, Terry L.

I: Neuropsychologia, Bind 48, Nr. 4, 03.2010, s. 854-62.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Response inhibition is associated with white matter microstructure in children

AU - Madsen, Kathrine Skak

AU - Baaré, William F C

AU - Vestergaard, Martin

AU - Skimminge, Arnold

AU - Ejersbo, Lisser Rye

AU - Ramsøy, Thomas Z

AU - Gerlach, Christian

AU - Akeson, Per

AU - Paulson, Olaf B

AU - Jernigan, Terry L

N1 - Copyright (c) 2009 Elsevier Ltd. All rights reserved.

PY - 2010/3

Y1 - 2010/3

N2 - Cognitive control of thoughts, actions and emotions is important for normal behaviour and the development of such control continues throughout childhood and adolescence. Several lines of evidence suggest that response inhibition is primarily mediated by a right-lateralized network involving inferior frontal gyrus (IFG), presupplementary motor cortex (preSMA), and subthalamic nucleus. Though the brain's fibre tracts are known to develop during childhood, little is known about how fibre tract development within this network relates to developing behavioural control. Here we examined the relationship between response inhibition, as measured with the stop-signal task, and indices of regional white matter microstructure in typically-developing children. We hypothesized that better response inhibition performance would be associated with higher fractional anisotropy (FA) in fibre tracts within right IFG and preSMA after controlling for age. Mean FA and diffusivity values were extracted from right and left IFG and preSMA. As hypothesized, faster response inhibition was significantly associated with higher FA and lower perpendicular diffusivity in both the right IFG and the right preSMA, possibly reflecting faster speed of neural conduction within more densely packed or better myelinated fibre tracts. Moreover, both of these effects remained significant after controlling for age and whole brain estimates of these DTI parameters. Interestingly, right IFG and preSMA FA contributed additively to the prediction of performance variability. Observed associations may be related to variation in phase of maturation, to activity-dependent alterations in the network subserving response inhibition, or to stable individual differences in underlying neural system connectivity.

AB - Cognitive control of thoughts, actions and emotions is important for normal behaviour and the development of such control continues throughout childhood and adolescence. Several lines of evidence suggest that response inhibition is primarily mediated by a right-lateralized network involving inferior frontal gyrus (IFG), presupplementary motor cortex (preSMA), and subthalamic nucleus. Though the brain's fibre tracts are known to develop during childhood, little is known about how fibre tract development within this network relates to developing behavioural control. Here we examined the relationship between response inhibition, as measured with the stop-signal task, and indices of regional white matter microstructure in typically-developing children. We hypothesized that better response inhibition performance would be associated with higher fractional anisotropy (FA) in fibre tracts within right IFG and preSMA after controlling for age. Mean FA and diffusivity values were extracted from right and left IFG and preSMA. As hypothesized, faster response inhibition was significantly associated with higher FA and lower perpendicular diffusivity in both the right IFG and the right preSMA, possibly reflecting faster speed of neural conduction within more densely packed or better myelinated fibre tracts. Moreover, both of these effects remained significant after controlling for age and whole brain estimates of these DTI parameters. Interestingly, right IFG and preSMA FA contributed additively to the prediction of performance variability. Observed associations may be related to variation in phase of maturation, to activity-dependent alterations in the network subserving response inhibition, or to stable individual differences in underlying neural system connectivity.

KW - Adolescent

KW - Age Factors

KW - Brain

KW - Child

KW - Female

KW - Frontal Lobe

KW - Functional Laterality

KW - Humans

KW - Image Processing, Computer-Assisted

KW - Inhibition (Psychology)

KW - Linear Models

KW - Magnetic Resonance Imaging

KW - Male

KW - Motor Cortex

KW - Neural Pathways

KW - Neuropsychological Tests

KW - Psychomotor Performance

KW - Reaction Time

U2 - 10.1016/j.neuropsychologia.2009.11.001

DO - 10.1016/j.neuropsychologia.2009.11.001

M3 - Journal article

VL - 48

SP - 854

EP - 862

JO - Neuropsychologia

JF - Neuropsychologia

SN - 0028-3932

IS - 4

ER -

Madsen KS, Baaré WFC, Vestergaard M, Skimminge A, Ejersbo LR, Ramsøy TZ et al. Response inhibition is associated with white matter microstructure in children. Neuropsychologia. 2010 mar;48(4):854-62. https://doi.org/10.1016/j.neuropsychologia.2009.11.001