Resistance to first-line anti-TB drugs is associated with reduced nitric oxide susceptibility in Mycobacterium tuberculosis

Jonna Idh, Mekidim Mekonnen, Ebba Abate, Wassihun Wedajo, Jim Werngren, Kristian Ängeby, Maria Lerm, Daniel Elias, Tommy Sundqvist, Abraham Aseffa, Olle Stendahl, Thomas Schön

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Abstrakt

The relative contribution of nitric oxide (NO) to the killing of Mycobacterium tuberculosis in human tuberculosis (TB) is controversial, although this has been firmly established in rodents. Studies have demonstrated that clinical strains of M. tuberculosis differ in susceptibility to NO, but how this correlates to drug susceptibility and clinical outcome is not known.
OriginalsprogEngelsk
TidsskriftP L o S One
Vol/bind7
Udgave nummer6
Sider (fra-til)e39891
ISSN1932-6203
DOI
StatusUdgivet - 2012

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Citationsformater

Idh, J., Mekonnen, M., Abate, E., Wedajo, W., Werngren, J., Ängeby, K., Lerm, M., Elias, D., Sundqvist, T., Aseffa, A., Stendahl, O., & Schön, T. (2012). Resistance to first-line anti-TB drugs is associated with reduced nitric oxide susceptibility in Mycobacterium tuberculosis. P L o S One, 7(6), e39891. https://doi.org/10.1371/journal.pone.0039891