Reproducibility of semi-automatic coronary plaque quantification in coronary CT angiography with sub-mSv radiation dose

K. A. Ovrehus, A. Schuhbaeck, Mohamed Marwan, Stephan Achenbach, B. L. Norgaard, H. E. Botker, D. Dey

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Introduction: Coronary computed tomographic angiography (CTA) can characterize coronary atherosclerotic plaque components as calcified and non-calcified. Quantitative measurements of coronary plaque burden by coronary CTA may play a role in serial studies to determine disease progression or response to medical therapies. The reproducibility from repeated assessment of such quantitative measurements from low-radiation dose coronary CTA has not been previously assessed. Purpose: To evaluate the interscan, interobserver and intraobserver reproducibility for coronary plaque volume assessment using semi-automatic plaque analyses algorithm in low radiation dose coronary CTA. Methods: In 50 consecutive patients undergoing two 128-slice dual source CT scans within 12 days with a mean radiation dose of 0.7 mSv per coronary CTA, the interscan, interobserver and intraobserver reproducibility of coronary plaque assessment using validated software (AutoPlaq) were evaluated. Results: Interscan, interobserver and intraobserver agreement for non-calcified and calcified plaque volumes were excellent (Spearman rho 0.87-0.99). Interscan mean percentage difference in non-calcified and calcified plaque volumes were 0.1% (p = 0.8) and 1.9% (p = 0.19) with limits of agreement of +/- 11% and +/- 48.5%; per inter-and intraobserver mean percentage differences were 0.1% (p = 0.25) and 0.3% (p = 0.001), and 0.3% (p = 0.33) and 0.4% (p = 0.59) with limits of agreement of +/- 7% and +/- 32.9%, and +/- 6.6% and +/- 32.1%, respectively. Conclusion: A semi-automatic plaque assessment algorithm in repeated low radiation dose coronary CTA allows for high reproducibility of coronary plaque characterization and quantification measures. (C) 2016 Society of Cardiovascular Computed Tomography. Published by Elsevier Inc. All rights reserved.
OriginalsprogEngelsk
TidsskriftJournal of Cardiovascular Computed Tomography
Vol/bind10
Udgave nummer2
Sider (fra-til)114-120
ISSN1934-5925
DOI
StatusUdgivet - 2016

Fingeraftryk

Coronary Angiography
Atherosclerotic Plaques
Computed Tomography Angiography

Citer dette

Ovrehus, K. A. ; Schuhbaeck, A. ; Marwan, Mohamed ; Achenbach, Stephan ; Norgaard, B. L. ; Botker, H. E. ; Dey, D. / Reproducibility of semi-automatic coronary plaque quantification in coronary CT angiography with sub-mSv radiation dose. I: Journal of Cardiovascular Computed Tomography. 2016 ; Bind 10, Nr. 2. s. 114-120.
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title = "Reproducibility of semi-automatic coronary plaque quantification in coronary CT angiography with sub-mSv radiation dose",
abstract = "Introduction: Coronary computed tomographic angiography (CTA) can characterize coronary atherosclerotic plaque components as calcified and non-calcified. Quantitative measurements of coronary plaque burden by coronary CTA may play a role in serial studies to determine disease progression or response to medical therapies. The reproducibility from repeated assessment of such quantitative measurements from low-radiation dose coronary CTA has not been previously assessed. Purpose: To evaluate the interscan, interobserver and intraobserver reproducibility for coronary plaque volume assessment using semi-automatic plaque analyses algorithm in low radiation dose coronary CTA. Methods: In 50 consecutive patients undergoing two 128-slice dual source CT scans within 12 days with a mean radiation dose of 0.7 mSv per coronary CTA, the interscan, interobserver and intraobserver reproducibility of coronary plaque assessment using validated software (AutoPlaq) were evaluated. Results: Interscan, interobserver and intraobserver agreement for non-calcified and calcified plaque volumes were excellent (Spearman rho 0.87-0.99). Interscan mean percentage difference in non-calcified and calcified plaque volumes were 0.1{\%} (p = 0.8) and 1.9{\%} (p = 0.19) with limits of agreement of +/- 11{\%} and +/- 48.5{\%}; per inter-and intraobserver mean percentage differences were 0.1{\%} (p = 0.25) and 0.3{\%} (p = 0.001), and 0.3{\%} (p = 0.33) and 0.4{\%} (p = 0.59) with limits of agreement of +/- 7{\%} and +/- 32.9{\%}, and +/- 6.6{\%} and +/- 32.1{\%}, respectively. Conclusion: A semi-automatic plaque assessment algorithm in repeated low radiation dose coronary CTA allows for high reproducibility of coronary plaque characterization and quantification measures. (C) 2016 Society of Cardiovascular Computed Tomography. Published by Elsevier Inc. All rights reserved.",
keywords = "Coronary CT angiography Coronary artery disease Coronary plaque imaging computed tomographic angiography intravascular ultrasound atherosclerotic plaques prognostic value artery-disease metaanalysis attenuation validation prediction morphology Cardiovascular System & Cardiology Radiology, Nuclear Medicine & Medical Imaging",
author = "Ovrehus, {K. A.} and A. Schuhbaeck and Mohamed Marwan and Stephan Achenbach and Norgaard, {B. L.} and Botker, {H. E.} and D. Dey",
year = "2016",
doi = "10.1016/j.jcct.2015.11.003",
language = "English",
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Reproducibility of semi-automatic coronary plaque quantification in coronary CT angiography with sub-mSv radiation dose. / Ovrehus, K. A.; Schuhbaeck, A.; Marwan, Mohamed; Achenbach, Stephan; Norgaard, B. L.; Botker, H. E.; Dey, D.

I: Journal of Cardiovascular Computed Tomography, Bind 10, Nr. 2, 2016, s. 114-120.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Reproducibility of semi-automatic coronary plaque quantification in coronary CT angiography with sub-mSv radiation dose

AU - Ovrehus, K. A.

AU - Schuhbaeck, A.

AU - Marwan, Mohamed

AU - Achenbach, Stephan

AU - Norgaard, B. L.

AU - Botker, H. E.

AU - Dey, D.

PY - 2016

Y1 - 2016

N2 - Introduction: Coronary computed tomographic angiography (CTA) can characterize coronary atherosclerotic plaque components as calcified and non-calcified. Quantitative measurements of coronary plaque burden by coronary CTA may play a role in serial studies to determine disease progression or response to medical therapies. The reproducibility from repeated assessment of such quantitative measurements from low-radiation dose coronary CTA has not been previously assessed. Purpose: To evaluate the interscan, interobserver and intraobserver reproducibility for coronary plaque volume assessment using semi-automatic plaque analyses algorithm in low radiation dose coronary CTA. Methods: In 50 consecutive patients undergoing two 128-slice dual source CT scans within 12 days with a mean radiation dose of 0.7 mSv per coronary CTA, the interscan, interobserver and intraobserver reproducibility of coronary plaque assessment using validated software (AutoPlaq) were evaluated. Results: Interscan, interobserver and intraobserver agreement for non-calcified and calcified plaque volumes were excellent (Spearman rho 0.87-0.99). Interscan mean percentage difference in non-calcified and calcified plaque volumes were 0.1% (p = 0.8) and 1.9% (p = 0.19) with limits of agreement of +/- 11% and +/- 48.5%; per inter-and intraobserver mean percentage differences were 0.1% (p = 0.25) and 0.3% (p = 0.001), and 0.3% (p = 0.33) and 0.4% (p = 0.59) with limits of agreement of +/- 7% and +/- 32.9%, and +/- 6.6% and +/- 32.1%, respectively. Conclusion: A semi-automatic plaque assessment algorithm in repeated low radiation dose coronary CTA allows for high reproducibility of coronary plaque characterization and quantification measures. (C) 2016 Society of Cardiovascular Computed Tomography. Published by Elsevier Inc. All rights reserved.

AB - Introduction: Coronary computed tomographic angiography (CTA) can characterize coronary atherosclerotic plaque components as calcified and non-calcified. Quantitative measurements of coronary plaque burden by coronary CTA may play a role in serial studies to determine disease progression or response to medical therapies. The reproducibility from repeated assessment of such quantitative measurements from low-radiation dose coronary CTA has not been previously assessed. Purpose: To evaluate the interscan, interobserver and intraobserver reproducibility for coronary plaque volume assessment using semi-automatic plaque analyses algorithm in low radiation dose coronary CTA. Methods: In 50 consecutive patients undergoing two 128-slice dual source CT scans within 12 days with a mean radiation dose of 0.7 mSv per coronary CTA, the interscan, interobserver and intraobserver reproducibility of coronary plaque assessment using validated software (AutoPlaq) were evaluated. Results: Interscan, interobserver and intraobserver agreement for non-calcified and calcified plaque volumes were excellent (Spearman rho 0.87-0.99). Interscan mean percentage difference in non-calcified and calcified plaque volumes were 0.1% (p = 0.8) and 1.9% (p = 0.19) with limits of agreement of +/- 11% and +/- 48.5%; per inter-and intraobserver mean percentage differences were 0.1% (p = 0.25) and 0.3% (p = 0.001), and 0.3% (p = 0.33) and 0.4% (p = 0.59) with limits of agreement of +/- 7% and +/- 32.9%, and +/- 6.6% and +/- 32.1%, respectively. Conclusion: A semi-automatic plaque assessment algorithm in repeated low radiation dose coronary CTA allows for high reproducibility of coronary plaque characterization and quantification measures. (C) 2016 Society of Cardiovascular Computed Tomography. Published by Elsevier Inc. All rights reserved.

KW - Coronary CT angiography Coronary artery disease Coronary plaque imaging computed tomographic angiography intravascular ultrasound atherosclerotic plaques prognostic value artery-disease metaanalysis attenuation validation prediction morphology Cardiovascu

U2 - 10.1016/j.jcct.2015.11.003

DO - 10.1016/j.jcct.2015.11.003

M3 - Journal article

C2 - 26712694

VL - 10

SP - 114

EP - 120

JO - Journal of Cardiovascular Computed Tomography

JF - Journal of Cardiovascular Computed Tomography

SN - 1934-5925

IS - 2

ER -