Reproducibility of automated simplified voxel-based analysis of PET amyloid ligand [11C]PIB uptake using 30-min scanning data

Sargo Aalto, Noora M Scheinin, Nina M Kemppainen, Kjell Någren, Marita Kailajärvi, Mika Leinonen, Mika Scheinin, Juha O Rinne

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Udgivelsesdato: 2009-Oct
OriginalsprogEngelsk
TidsskriftEuropean Journal of Nuclear Medicine and Molecular Imaging
Vol/bind36
Udgave nummer10
Sider (fra-til)1651-60
Antal sider9
ISSN1619-7070
DOI
StatusUdgivet - 1. okt. 2009
Udgivet eksterntJa

Fingeraftryk

Ligands
Alzheimer Disease
Sample Size
N-methyl-2-(4'-methylaminophenyl)-6-hydroxybenzothiazole
Power (Psychology)

Citer dette

Aalto, Sargo ; Scheinin, Noora M ; Kemppainen, Nina M ; Någren, Kjell ; Kailajärvi, Marita ; Leinonen, Mika ; Scheinin, Mika ; Rinne, Juha O. / Reproducibility of automated simplified voxel-based analysis of PET amyloid ligand [11C]PIB uptake using 30-min scanning data. I: European Journal of Nuclear Medicine and Molecular Imaging. 2009 ; Bind 36, Nr. 10. s. 1651-60.
@article{aa86b3e00f2711dfaefb000ea68e967b,
title = "Reproducibility of automated simplified voxel-based analysis of PET amyloid ligand [11C]PIB uptake using 30-min scanning data",
abstract = "PURPOSE: Positron emission tomography (PET) with 11C-labelled Pittsburgh compound B ([11C]PIB) enables the quantitation of beta-amyloid accumulation in the brain of patients with Alzheimer's disease (AD). Voxel-based image analysis techniques conducted in a standard brain space provide an objective, rapid and fully automated method to analyze [11C]PIB PET data. The purpose of this study was to evaluate both region- and voxel-level reproducibility of automated and simplified [11C]PIB quantitation when using only 30 min of imaging data. METHODS: Six AD patients and four healthy controls were scanned twice with an average interval of 6 weeks. To evaluate the feasibility of short scanning (convenient for AD patients), [11C]PIB uptake was quantitated using 30 min of imaging data (60 to 90 min after tracer injection) for region-to-cerebellum ratio calculations. To evaluate the reproducibility, a test-retest design was used to derive absolute variability (VAR) estimates and intraclass correlation coefficients at both region-of-interest (ROI) and voxel level. RESULTS: The reproducibility both at the region level (VAR 0.9-5.5{\%}) and at the voxel level (VAR 4.2-6.4{\%}) was good to excellent. Based on the variability estimates obtained, power calculations indicated that 90{\%} power to obtain statistically significant difference can be achieved using a sample size of five subjects per group when a 15{\%} change from baseline (increase or decrease) in [11C]PIB accumulation in the frontal cortex is anticipated in one group compared to no change in another group. CONCLUSION: Our results showed that an automated analysis method based on an efficient scanning protocol provides reproducible results for [11C]PIB uptake and appears suitable for PET studies aiming at the quantitation of amyloid accumulation in the brain of AD patients for the evaluation of progression and treatment effects.",
author = "Sargo Aalto and Scheinin, {Noora M} and Kemppainen, {Nina M} and Kjell N{\aa}gren and Marita Kailaj{\"a}rvi and Mika Leinonen and Mika Scheinin and Rinne, {Juha O}",
year = "2009",
month = "10",
day = "1",
doi = "10.1007/s00259-009-1174-1",
language = "English",
volume = "36",
pages = "1651--60",
journal = "European Journal of Nuclear Medicine and Molecular Imaging",
issn = "1619-7070",
publisher = "Heinemann",
number = "10",

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Reproducibility of automated simplified voxel-based analysis of PET amyloid ligand [11C]PIB uptake using 30-min scanning data. / Aalto, Sargo; Scheinin, Noora M; Kemppainen, Nina M; Någren, Kjell; Kailajärvi, Marita; Leinonen, Mika; Scheinin, Mika; Rinne, Juha O.

I: European Journal of Nuclear Medicine and Molecular Imaging, Bind 36, Nr. 10, 01.10.2009, s. 1651-60.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Reproducibility of automated simplified voxel-based analysis of PET amyloid ligand [11C]PIB uptake using 30-min scanning data

AU - Aalto, Sargo

AU - Scheinin, Noora M

AU - Kemppainen, Nina M

AU - Någren, Kjell

AU - Kailajärvi, Marita

AU - Leinonen, Mika

AU - Scheinin, Mika

AU - Rinne, Juha O

PY - 2009/10/1

Y1 - 2009/10/1

N2 - PURPOSE: Positron emission tomography (PET) with 11C-labelled Pittsburgh compound B ([11C]PIB) enables the quantitation of beta-amyloid accumulation in the brain of patients with Alzheimer's disease (AD). Voxel-based image analysis techniques conducted in a standard brain space provide an objective, rapid and fully automated method to analyze [11C]PIB PET data. The purpose of this study was to evaluate both region- and voxel-level reproducibility of automated and simplified [11C]PIB quantitation when using only 30 min of imaging data. METHODS: Six AD patients and four healthy controls were scanned twice with an average interval of 6 weeks. To evaluate the feasibility of short scanning (convenient for AD patients), [11C]PIB uptake was quantitated using 30 min of imaging data (60 to 90 min after tracer injection) for region-to-cerebellum ratio calculations. To evaluate the reproducibility, a test-retest design was used to derive absolute variability (VAR) estimates and intraclass correlation coefficients at both region-of-interest (ROI) and voxel level. RESULTS: The reproducibility both at the region level (VAR 0.9-5.5%) and at the voxel level (VAR 4.2-6.4%) was good to excellent. Based on the variability estimates obtained, power calculations indicated that 90% power to obtain statistically significant difference can be achieved using a sample size of five subjects per group when a 15% change from baseline (increase or decrease) in [11C]PIB accumulation in the frontal cortex is anticipated in one group compared to no change in another group. CONCLUSION: Our results showed that an automated analysis method based on an efficient scanning protocol provides reproducible results for [11C]PIB uptake and appears suitable for PET studies aiming at the quantitation of amyloid accumulation in the brain of AD patients for the evaluation of progression and treatment effects.

AB - PURPOSE: Positron emission tomography (PET) with 11C-labelled Pittsburgh compound B ([11C]PIB) enables the quantitation of beta-amyloid accumulation in the brain of patients with Alzheimer's disease (AD). Voxel-based image analysis techniques conducted in a standard brain space provide an objective, rapid and fully automated method to analyze [11C]PIB PET data. The purpose of this study was to evaluate both region- and voxel-level reproducibility of automated and simplified [11C]PIB quantitation when using only 30 min of imaging data. METHODS: Six AD patients and four healthy controls were scanned twice with an average interval of 6 weeks. To evaluate the feasibility of short scanning (convenient for AD patients), [11C]PIB uptake was quantitated using 30 min of imaging data (60 to 90 min after tracer injection) for region-to-cerebellum ratio calculations. To evaluate the reproducibility, a test-retest design was used to derive absolute variability (VAR) estimates and intraclass correlation coefficients at both region-of-interest (ROI) and voxel level. RESULTS: The reproducibility both at the region level (VAR 0.9-5.5%) and at the voxel level (VAR 4.2-6.4%) was good to excellent. Based on the variability estimates obtained, power calculations indicated that 90% power to obtain statistically significant difference can be achieved using a sample size of five subjects per group when a 15% change from baseline (increase or decrease) in [11C]PIB accumulation in the frontal cortex is anticipated in one group compared to no change in another group. CONCLUSION: Our results showed that an automated analysis method based on an efficient scanning protocol provides reproducible results for [11C]PIB uptake and appears suitable for PET studies aiming at the quantitation of amyloid accumulation in the brain of AD patients for the evaluation of progression and treatment effects.

U2 - 10.1007/s00259-009-1174-1

DO - 10.1007/s00259-009-1174-1

M3 - Journal article

VL - 36

SP - 1651

EP - 1660

JO - European Journal of Nuclear Medicine and Molecular Imaging

JF - European Journal of Nuclear Medicine and Molecular Imaging

SN - 1619-7070

IS - 10

ER -