Relationship of glucose concentrations with PAI-1 and t-PA in subjects with normal glucose tolerance

P E Heldgaard, J J Sidelmann, C Hindsberger, N de F Olivarius, J E Henriksen, J Gram

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

AIM: To study metabolic risk factors for the development of cardiovascular disease (CVD), including markers of the fibrinolytic system in relation to blood glucose levels in subjects with normal glucose tolerance and fasting blood glucose levels below 5.6 mmol/l. METHODS: Cross-sectional, community-based study from a primary health-care centre of adult subjects with normal glucose tolerance. Analysis of fasting and 2-h post-load blood glucose concentrations were centralized and related to anthropometric characteristics, metabolic variables, inflammatory markers, and coagulation and fibrinolytic variables. RESULTS: Increasing fasting blood glucose concentrations within the normal range in subjects with normal glucose tolerance were associated with increasing age, body mass index, and waist circumference, and with increasing concentrations of metabolic risk factors for development of CVD. After adjustment for gender, age, body mass index (BMI), and fasting insulin, levels of plasmin activator inhibitor (PAI-1) and tissue type plasminogen activator (t-PA) increased significantly with increasing levels of fasting glucose within the normal range (P = 0.012 and P < 0.0001, respectively). CONCLUSIONS: We found risk factors for CVD, specifically key components of the fibrinolytic system, PAI-1 and t-PA, increased with increasing fasting glucose levels even in subjects with normal glucose tolerance. This observation may help to explain the increased risk of CVD with increasing values of fasting glucose in the normal range.
OriginalsprogEngelsk
TidsskriftDiabetic Medicine
Vol/bind23
Udgave nummer8
Sider (fra-til)887-893
Antal sider6
ISSN0742-3071
DOI
StatusUdgivet - 2006

Fingeraftryk

Plasminogen Activator Inhibitor 1
Fasting
Reference Values
Body Mass Index
Tissue Plasminogen Activator
Primary Health Care
Insulin

Citer dette

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title = "Relationship of glucose concentrations with PAI-1 and t-PA in subjects with normal glucose tolerance",
abstract = "AIM: To study metabolic risk factors for the development of cardiovascular disease (CVD), including markers of the fibrinolytic system in relation to blood glucose levels in subjects with normal glucose tolerance and fasting blood glucose levels below 5.6 mmol/l. METHODS: Cross-sectional, community-based study from a primary health-care centre of adult subjects with normal glucose tolerance. Analysis of fasting and 2-h post-load blood glucose concentrations were centralized and related to anthropometric characteristics, metabolic variables, inflammatory markers, and coagulation and fibrinolytic variables. RESULTS: Increasing fasting blood glucose concentrations within the normal range in subjects with normal glucose tolerance were associated with increasing age, body mass index, and waist circumference, and with increasing concentrations of metabolic risk factors for development of CVD. After adjustment for gender, age, body mass index (BMI), and fasting insulin, levels of plasmin activator inhibitor (PAI-1) and tissue type plasminogen activator (t-PA) increased significantly with increasing levels of fasting glucose within the normal range (P = 0.012 and P < 0.0001, respectively). CONCLUSIONS: We found risk factors for CVD, specifically key components of the fibrinolytic system, PAI-1 and t-PA, increased with increasing fasting glucose levels even in subjects with normal glucose tolerance. This observation may help to explain the increased risk of CVD with increasing values of fasting glucose in the normal range.",
keywords = "Adult, Blood Glucose, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Diabetic Angiopathies, Fasting, Female, Humans, Male, Metabolic Syndrome X, Middle Aged, Plasminogen Activators, Risk Factors, Tissue Plasminogen Activator",
author = "Heldgaard, {P E} and Sidelmann, {J J} and C Hindsberger and Olivarius, {N de F} and Henriksen, {J E} and J Gram",
year = "2006",
doi = "10.1111/j.1464-5491.2006.01924.x",
language = "English",
volume = "23",
pages = "887--893",
journal = "Diabetic Medicine",
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Relationship of glucose concentrations with PAI-1 and t-PA in subjects with normal glucose tolerance. / Heldgaard, P E; Sidelmann, J J; Hindsberger, C; Olivarius, N de F; Henriksen, J E; Gram, J.

I: Diabetic Medicine, Bind 23, Nr. 8, 2006, s. 887-893.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Relationship of glucose concentrations with PAI-1 and t-PA in subjects with normal glucose tolerance

AU - Heldgaard, P E

AU - Sidelmann, J J

AU - Hindsberger, C

AU - Olivarius, N de F

AU - Henriksen, J E

AU - Gram, J

PY - 2006

Y1 - 2006

N2 - AIM: To study metabolic risk factors for the development of cardiovascular disease (CVD), including markers of the fibrinolytic system in relation to blood glucose levels in subjects with normal glucose tolerance and fasting blood glucose levels below 5.6 mmol/l. METHODS: Cross-sectional, community-based study from a primary health-care centre of adult subjects with normal glucose tolerance. Analysis of fasting and 2-h post-load blood glucose concentrations were centralized and related to anthropometric characteristics, metabolic variables, inflammatory markers, and coagulation and fibrinolytic variables. RESULTS: Increasing fasting blood glucose concentrations within the normal range in subjects with normal glucose tolerance were associated with increasing age, body mass index, and waist circumference, and with increasing concentrations of metabolic risk factors for development of CVD. After adjustment for gender, age, body mass index (BMI), and fasting insulin, levels of plasmin activator inhibitor (PAI-1) and tissue type plasminogen activator (t-PA) increased significantly with increasing levels of fasting glucose within the normal range (P = 0.012 and P < 0.0001, respectively). CONCLUSIONS: We found risk factors for CVD, specifically key components of the fibrinolytic system, PAI-1 and t-PA, increased with increasing fasting glucose levels even in subjects with normal glucose tolerance. This observation may help to explain the increased risk of CVD with increasing values of fasting glucose in the normal range.

AB - AIM: To study metabolic risk factors for the development of cardiovascular disease (CVD), including markers of the fibrinolytic system in relation to blood glucose levels in subjects with normal glucose tolerance and fasting blood glucose levels below 5.6 mmol/l. METHODS: Cross-sectional, community-based study from a primary health-care centre of adult subjects with normal glucose tolerance. Analysis of fasting and 2-h post-load blood glucose concentrations were centralized and related to anthropometric characteristics, metabolic variables, inflammatory markers, and coagulation and fibrinolytic variables. RESULTS: Increasing fasting blood glucose concentrations within the normal range in subjects with normal glucose tolerance were associated with increasing age, body mass index, and waist circumference, and with increasing concentrations of metabolic risk factors for development of CVD. After adjustment for gender, age, body mass index (BMI), and fasting insulin, levels of plasmin activator inhibitor (PAI-1) and tissue type plasminogen activator (t-PA) increased significantly with increasing levels of fasting glucose within the normal range (P = 0.012 and P < 0.0001, respectively). CONCLUSIONS: We found risk factors for CVD, specifically key components of the fibrinolytic system, PAI-1 and t-PA, increased with increasing fasting glucose levels even in subjects with normal glucose tolerance. This observation may help to explain the increased risk of CVD with increasing values of fasting glucose in the normal range.

KW - Adult

KW - Blood Glucose

KW - Cross-Sectional Studies

KW - Diabetes Mellitus, Type 2

KW - Diabetic Angiopathies

KW - Fasting

KW - Female

KW - Humans

KW - Male

KW - Metabolic Syndrome X

KW - Middle Aged

KW - Plasminogen Activators

KW - Risk Factors

KW - Tissue Plasminogen Activator

U2 - 10.1111/j.1464-5491.2006.01924.x

DO - 10.1111/j.1464-5491.2006.01924.x

M3 - Journal article

C2 - 16911627

VL - 23

SP - 887

EP - 893

JO - Diabetic Medicine

JF - Diabetic Medicine

SN - 0742-3071

IS - 8

ER -