Relation between body composition and biochemical markers of bone turnover among early postmenopausal women

M M Hla, J W Davis, P D Ross, J Yates, R D Wasnich, Pernille Ravn, M McClung, D Hosking

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

We studied the associations between body composition and biochemical markers of bone formation and resorption among 1600 postmenopausal women, ages 45-59. Multiple regression analyses were performed to examine the independent associations of fat mass, muscle strength (quadriceps strength), height, and whole body bone mineral content (BMC) with biochemical markers of bone formation (serum osteocalcin) and resorption (urinary type I collagen crosslinked N-telopeptides [NTX]). Per interquartile range (IQR) (the difference between 75th and 25th percentiles) increase in fat mass and whole body BMC, the mean levels of osteocalcin decreased by 3% and 13%, respectively; NTX decreased by 5 and 21%. Fat mass and whole-body BMC were also significantly associated with decreases in the average of osteocalcin and NTX Z-scores. By contrast, the mean levels of serum osteocalcin increased by 2 and 11%, respectively, per IQR increase in muscle strength and height; NTX increased by 4 (not significant) and 14%, respectively. Both muscle strength and height were significantly associated with increases in the average Z-scores. These exploratory analyses suggest that fat mass and whole-body BMC were associated with decreased bone turnover, while muscle strength and height were associated with increased bone turnover.

OriginalsprogEngelsk
TidsskriftJournal of Clinical Densitometry
Vol/bind3
Udgave nummer4
Sider (fra-til)365-71
Antal sider7
ISSN1094-6950
StatusUdgivet - 2000

Fingeraftryk

Osteocalcin
Bone Density
Fats
Osteogenesis
Collagen Type I
Serum
Regression Analysis

Citer dette

Hla, M. M., Davis, J. W., Ross, P. D., Yates, J., Wasnich, R. D., Ravn, P., ... Hosking, D. (2000). Relation between body composition and biochemical markers of bone turnover among early postmenopausal women. Journal of Clinical Densitometry, 3(4), 365-71.
Hla, M M ; Davis, J W ; Ross, P D ; Yates, J ; Wasnich, R D ; Ravn, Pernille ; McClung, M ; Hosking, D. / Relation between body composition and biochemical markers of bone turnover among early postmenopausal women. I: Journal of Clinical Densitometry. 2000 ; Bind 3, Nr. 4. s. 365-71.
@article{2df62d85dc1f4eb99217eceb6c2712f2,
title = "Relation between body composition and biochemical markers of bone turnover among early postmenopausal women",
abstract = "We studied the associations between body composition and biochemical markers of bone formation and resorption among 1600 postmenopausal women, ages 45-59. Multiple regression analyses were performed to examine the independent associations of fat mass, muscle strength (quadriceps strength), height, and whole body bone mineral content (BMC) with biochemical markers of bone formation (serum osteocalcin) and resorption (urinary type I collagen crosslinked N-telopeptides [NTX]). Per interquartile range (IQR) (the difference between 75th and 25th percentiles) increase in fat mass and whole body BMC, the mean levels of osteocalcin decreased by 3{\%} and 13{\%}, respectively; NTX decreased by 5 and 21{\%}. Fat mass and whole-body BMC were also significantly associated with decreases in the average of osteocalcin and NTX Z-scores. By contrast, the mean levels of serum osteocalcin increased by 2 and 11{\%}, respectively, per IQR increase in muscle strength and height; NTX increased by 4 (not significant) and 14{\%}, respectively. Both muscle strength and height were significantly associated with increases in the average Z-scores. These exploratory analyses suggest that fat mass and whole-body BMC were associated with decreased bone turnover, while muscle strength and height were associated with increased bone turnover.",
keywords = "Adipose Tissue, Body Composition, Bone Remodeling, Bone Resorption, Female, Humans, Immunoradiometric Assay, Middle Aged, Muscle, Skeletal, Osteocalcin, Osteogenesis, Postmenopause, Randomized Controlled Trials as Topic, Regression Analysis",
author = "Hla, {M M} and Davis, {J W} and Ross, {P D} and J Yates and Wasnich, {R D} and Pernille Ravn and M McClung and D Hosking",
year = "2000",
language = "English",
volume = "3",
pages = "365--71",
journal = "Journal of Clinical Densitometry",
issn = "1094-6950",
publisher = "Elsevier",
number = "4",

}

Hla, MM, Davis, JW, Ross, PD, Yates, J, Wasnich, RD, Ravn, P, McClung, M & Hosking, D 2000, 'Relation between body composition and biochemical markers of bone turnover among early postmenopausal women', Journal of Clinical Densitometry, bind 3, nr. 4, s. 365-71.

Relation between body composition and biochemical markers of bone turnover among early postmenopausal women. / Hla, M M; Davis, J W; Ross, P D; Yates, J; Wasnich, R D; Ravn, Pernille; McClung, M; Hosking, D.

I: Journal of Clinical Densitometry, Bind 3, Nr. 4, 2000, s. 365-71.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Relation between body composition and biochemical markers of bone turnover among early postmenopausal women

AU - Hla, M M

AU - Davis, J W

AU - Ross, P D

AU - Yates, J

AU - Wasnich, R D

AU - Ravn, Pernille

AU - McClung, M

AU - Hosking, D

PY - 2000

Y1 - 2000

N2 - We studied the associations between body composition and biochemical markers of bone formation and resorption among 1600 postmenopausal women, ages 45-59. Multiple regression analyses were performed to examine the independent associations of fat mass, muscle strength (quadriceps strength), height, and whole body bone mineral content (BMC) with biochemical markers of bone formation (serum osteocalcin) and resorption (urinary type I collagen crosslinked N-telopeptides [NTX]). Per interquartile range (IQR) (the difference between 75th and 25th percentiles) increase in fat mass and whole body BMC, the mean levels of osteocalcin decreased by 3% and 13%, respectively; NTX decreased by 5 and 21%. Fat mass and whole-body BMC were also significantly associated with decreases in the average of osteocalcin and NTX Z-scores. By contrast, the mean levels of serum osteocalcin increased by 2 and 11%, respectively, per IQR increase in muscle strength and height; NTX increased by 4 (not significant) and 14%, respectively. Both muscle strength and height were significantly associated with increases in the average Z-scores. These exploratory analyses suggest that fat mass and whole-body BMC were associated with decreased bone turnover, while muscle strength and height were associated with increased bone turnover.

AB - We studied the associations between body composition and biochemical markers of bone formation and resorption among 1600 postmenopausal women, ages 45-59. Multiple regression analyses were performed to examine the independent associations of fat mass, muscle strength (quadriceps strength), height, and whole body bone mineral content (BMC) with biochemical markers of bone formation (serum osteocalcin) and resorption (urinary type I collagen crosslinked N-telopeptides [NTX]). Per interquartile range (IQR) (the difference between 75th and 25th percentiles) increase in fat mass and whole body BMC, the mean levels of osteocalcin decreased by 3% and 13%, respectively; NTX decreased by 5 and 21%. Fat mass and whole-body BMC were also significantly associated with decreases in the average of osteocalcin and NTX Z-scores. By contrast, the mean levels of serum osteocalcin increased by 2 and 11%, respectively, per IQR increase in muscle strength and height; NTX increased by 4 (not significant) and 14%, respectively. Both muscle strength and height were significantly associated with increases in the average Z-scores. These exploratory analyses suggest that fat mass and whole-body BMC were associated with decreased bone turnover, while muscle strength and height were associated with increased bone turnover.

KW - Adipose Tissue

KW - Body Composition

KW - Bone Remodeling

KW - Bone Resorption

KW - Female

KW - Humans

KW - Immunoradiometric Assay

KW - Middle Aged

KW - Muscle, Skeletal

KW - Osteocalcin

KW - Osteogenesis

KW - Postmenopause

KW - Randomized Controlled Trials as Topic

KW - Regression Analysis

M3 - Journal article

VL - 3

SP - 365

EP - 371

JO - Journal of Clinical Densitometry

JF - Journal of Clinical Densitometry

SN - 1094-6950

IS - 4

ER -