Regulation of metabolism by long, non-coding RNAs

Jan-Wilhelm Kornfeld, Jens C Brüning

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstract

Our understanding of genomic regulation was revolutionized by the discovery that the genome is pervasively transcribed, giving rise to thousands of mostly uncharacterized non-coding ribonucleic acids (ncRNAs). Long, ncRNAs (lncRNAs) have thus emerged as a novel class of functional RNAs that impinge on gene regulation by a broad spectrum of mechanisms such as the recruitment of epigenetic modifier proteins, control of mRNA decay and DNA sequestration of transcription factors. We review those lncRNAs that are implicated in differentiation and homeostasis of metabolic tissues and present novel concepts on how lncRNAs might act on energy and glucose homeostasis. Finally, the control of circadian rhythm by lncRNAs is an emerging principles of lncRNA-mediated gene regulation.

OriginalsprogEngelsk
Artikelnummer57
TidsskriftFrontiers in Genetics
Vol/bind5
ISSN1664-8021
DOI
StatusUdgivet - 2014
Udgivet eksterntJa

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