Reference values for fasting serum concentrations of thyroid-stimulating hormone and thyroid hormones in healthy Danish/North-European white children and adolescents

Gowthami Gunapalasingham, Christine Frithioff-Bøjsøe*, Morten Asp Vonsild Lund, Paula Louise Hedley, Cilius Esmann Fonvig, Maria Dahl, Oluf Pedersen, Michael Christiansen, Torben Hansen, Ulrik Lausten-Thomsen, Jens Christian Holm

*Kontaktforfatter for dette arbejde

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Resumé

Thyroid-stimulating hormone (TSH) and thyroid hormones influence the functions of many organ systems, as well as child development and growth. Several studies have reported an association between ethnicity and thyroid hormones. This study aims to explore pediatric serum concentrations of TSH, free triiodothyronine (fT3), and free thyroxine (fT4) and their relation to age and sex and subsequently to present pediatric reference intervals from healthy Danish/North-European white children. A population-based cohort in Denmark of 2411 (1435 girls) healthy school children and adolescents aged 6.0–18.9 years were included. Fasting concentrations of serum TSH, fT3, and fT4 were determined from venous blood samples using immunologic chemiluminescent assays. Age- and sex-dependent percentiles were generated using the GAMLSS function. Median values of fT3 and fT4, but not TSH, were lower in the older age group compared with the youngest age group for both sexes (all p <.05). A significant difference for fT3 was found between the sexes for all age groups (all p <.001). fT4 was negatively correlated with body mass index standard deviation scores in boys. In conclusion, serum concentrations of thyroid hormones vary during childhood and adolescence and differ with age and sex.

OriginalsprogEngelsk
TidsskriftScandinavian Journal of Clinical & Laboratory Investigation
Vol/bind79
Udgave nummer1-2
Sider (fra-til)129-135
ISSN0036-5513
DOI
StatusUdgivet - mar. 2019

Fingeraftryk

Fasting
Reference Values
Serum
Age Groups
Pediatrics
Luminescent Measurements
Denmark
Body Mass Index
Growth
Population

Citer dette

Gunapalasingham, Gowthami ; Frithioff-Bøjsøe, Christine ; Lund, Morten Asp Vonsild ; Hedley, Paula Louise ; Fonvig, Cilius Esmann ; Dahl, Maria ; Pedersen, Oluf ; Christiansen, Michael ; Hansen, Torben ; Lausten-Thomsen, Ulrik ; Holm, Jens Christian. / Reference values for fasting serum concentrations of thyroid-stimulating hormone and thyroid hormones in healthy Danish/North-European white children and adolescents. I: Scandinavian Journal of Clinical & Laboratory Investigation. 2019 ; Bind 79, Nr. 1-2. s. 129-135.
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abstract = "Thyroid-stimulating hormone (TSH) and thyroid hormones influence the functions of many organ systems, as well as child development and growth. Several studies have reported an association between ethnicity and thyroid hormones. This study aims to explore pediatric serum concentrations of TSH, free triiodothyronine (fT3), and free thyroxine (fT4) and their relation to age and sex and subsequently to present pediatric reference intervals from healthy Danish/North-European white children. A population-based cohort in Denmark of 2411 (1435 girls) healthy school children and adolescents aged 6.0–18.9 years were included. Fasting concentrations of serum TSH, fT3, and fT4 were determined from venous blood samples using immunologic chemiluminescent assays. Age- and sex-dependent percentiles were generated using the GAMLSS function. Median values of fT3 and fT4, but not TSH, were lower in the older age group compared with the youngest age group for both sexes (all p <.05). A significant difference for fT3 was found between the sexes for all age groups (all p <.001). fT4 was negatively correlated with body mass index standard deviation scores in boys. In conclusion, serum concentrations of thyroid hormones vary during childhood and adolescence and differ with age and sex.",
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Reference values for fasting serum concentrations of thyroid-stimulating hormone and thyroid hormones in healthy Danish/North-European white children and adolescents. / Gunapalasingham, Gowthami; Frithioff-Bøjsøe, Christine; Lund, Morten Asp Vonsild; Hedley, Paula Louise; Fonvig, Cilius Esmann; Dahl, Maria; Pedersen, Oluf; Christiansen, Michael; Hansen, Torben; Lausten-Thomsen, Ulrik; Holm, Jens Christian.

I: Scandinavian Journal of Clinical & Laboratory Investigation, Bind 79, Nr. 1-2, 03.2019, s. 129-135.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Reference values for fasting serum concentrations of thyroid-stimulating hormone and thyroid hormones in healthy Danish/North-European white children and adolescents

AU - Gunapalasingham, Gowthami

AU - Frithioff-Bøjsøe, Christine

AU - Lund, Morten Asp Vonsild

AU - Hedley, Paula Louise

AU - Fonvig, Cilius Esmann

AU - Dahl, Maria

AU - Pedersen, Oluf

AU - Christiansen, Michael

AU - Hansen, Torben

AU - Lausten-Thomsen, Ulrik

AU - Holm, Jens Christian

PY - 2019/3

Y1 - 2019/3

N2 - Thyroid-stimulating hormone (TSH) and thyroid hormones influence the functions of many organ systems, as well as child development and growth. Several studies have reported an association between ethnicity and thyroid hormones. This study aims to explore pediatric serum concentrations of TSH, free triiodothyronine (fT3), and free thyroxine (fT4) and their relation to age and sex and subsequently to present pediatric reference intervals from healthy Danish/North-European white children. A population-based cohort in Denmark of 2411 (1435 girls) healthy school children and adolescents aged 6.0–18.9 years were included. Fasting concentrations of serum TSH, fT3, and fT4 were determined from venous blood samples using immunologic chemiluminescent assays. Age- and sex-dependent percentiles were generated using the GAMLSS function. Median values of fT3 and fT4, but not TSH, were lower in the older age group compared with the youngest age group for both sexes (all p <.05). A significant difference for fT3 was found between the sexes for all age groups (all p <.001). fT4 was negatively correlated with body mass index standard deviation scores in boys. In conclusion, serum concentrations of thyroid hormones vary during childhood and adolescence and differ with age and sex.

AB - Thyroid-stimulating hormone (TSH) and thyroid hormones influence the functions of many organ systems, as well as child development and growth. Several studies have reported an association between ethnicity and thyroid hormones. This study aims to explore pediatric serum concentrations of TSH, free triiodothyronine (fT3), and free thyroxine (fT4) and their relation to age and sex and subsequently to present pediatric reference intervals from healthy Danish/North-European white children. A population-based cohort in Denmark of 2411 (1435 girls) healthy school children and adolescents aged 6.0–18.9 years were included. Fasting concentrations of serum TSH, fT3, and fT4 were determined from venous blood samples using immunologic chemiluminescent assays. Age- and sex-dependent percentiles were generated using the GAMLSS function. Median values of fT3 and fT4, but not TSH, were lower in the older age group compared with the youngest age group for both sexes (all p <.05). A significant difference for fT3 was found between the sexes for all age groups (all p <.001). fT4 was negatively correlated with body mass index standard deviation scores in boys. In conclusion, serum concentrations of thyroid hormones vary during childhood and adolescence and differ with age and sex.

KW - Adolescent

KW - child

KW - humans

KW - reference values

KW - thyroid hormones

KW - thyrotropin

U2 - 10.1080/00365513.2019.1581945

DO - 10.1080/00365513.2019.1581945

M3 - Journal article

C2 - 30861348

AN - SCOPUS:85062800724

VL - 79

SP - 129

EP - 135

JO - Scandinavian Journal of Clinical & Laboratory Investigation

JF - Scandinavian Journal of Clinical & Laboratory Investigation

SN - 0036-5513

IS - 1-2

ER -