Reduced content of chloroatranol and atranol in oak moss absolute significantly reduces the elicitation potential of this fragrance material

Flemming Andersen, Kirsten H Andersen, Armand Bernois, Christophe Brault, Magnus Bruze, Hervé Eudes, Catherine Gadras, Anne-Cécile J Signoret, Kristian F Mose, Boris P Müller, Bernard Toulemonde, Klaus Ejner Andersen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstract

BACKGROUND: Oak moss absolute, an extract from the lichen Evernia prunastri, is a valued perfume ingredient but contains extreme allergens.

OBJECTIVES: To compare the elicitation properties of two preparations of oak moss absolute: 'classic oak moss', the historically used preparation, and 'new oak moss', with reduced contents of the major allergens atranol and chloroatranol.

PATIENTS/MATERIALS/METHODS: The two preparations were compared in randomized double-blinded repeated open application tests and serial dilution patch tests in 30 oak moss-sensitive volunteers and 30 non-allergic control subjects.

RESULTS: In both test models, new oak moss elicited significantly less allergic contact dermatitis in oak moss-sensitive subjects than classic oak moss. The control subjects did not react to either of the preparations.

CONCLUSIONS: New oak moss is still a fragrance allergen, but elicits less allergic contact dermatitis in previously oak moss-sensitized individuals, suggesting that new oak moss is less allergenic to non-sensitized individuals.

OriginalsprogEngelsk
TidsskriftContact Dermatitis
Vol/bind72
Udgave nummer2
Sider (fra-til)75-83
ISSN0105-1873
DOI
StatusUdgivet - 1. feb. 2015

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