Reconstruction of multicompartment oriented neuronal networks for the study of neurodegenerative diseases

Maéva Vignes*, Bérangère Deleglise, Paul Gougis, Laure Saias, Sebastien Magnifico, Laurent Malaquin, Bernard Brugg, Jean Louis Viovy, Jean Michel Peyrin

*Kontaktforfatter for dette arbejde

Publikation: Kapitel i bog/rapport/konference-proceedingKonferencebidrag i proceedingsForskningpeer review

Abstrakt

Experimental models used to study brain development and degeneration range from whole animal models, which preserve the anatomical structures but greatly limit the experimentation at the cellular level, to dissociated cell culture systems, that allow detailed manipulation of cell phenotype but lack the highly ordered and instructive brain environment. Thus new experimental models are needed to facilitate both individual cell manipulation and brain connectivity reconstruction. Here we present powerful microfluidic cell culture systems that allow us to handle neurons and axons in micron size environments and thus to mimic in vitro the development and/or degeneration of some physiological neuronal pathways.

OriginalsprogEngelsk
Titel14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Antal sider3
Vol/bind1
Publikationsdato1. dec. 2010
Sider43-45
ISBN (Trykt)9781618390622
StatusUdgivet - 1. dec. 2010
Begivenhed14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 - Groningen, Holland
Varighed: 3. okt. 20107. okt. 2010

Konference

Konference14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
LandHolland
ByGroningen
Periode03/10/201007/10/2010

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