Recognition of stapled histone H3K4me3 peptides by epigenetic reader proteins

Peter Betlem; Marijn N. Maas; Jim Middelburg; Bas J. G. E. Pieters; Jasmin Mecinović

doi:10.1039/D2CC04294K

Recognition of stapled histone H3K4me3 peptides by epigenetic reader proteins

Peter Betlem
, Marijn N. Maas
, Jim Middelburg
, Bas J. G. E. Pieters
, Jasmin Mecinović^*

^*Kontaktforfatter

Radboud University Nijmegen

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Abstract

The flexible N-terminal histone tails are a subject of numerous posttranslational modifications, including methylation. We report development of stapled histone peptides bearing trimethyllysine as ligands for epigenetic reader proteins. Stronger or weaker binding affinities have been observed for stapled histone peptides relative to linear histones, indicating that selectivity towards reader proteins can be achieved.

Originalsprog	Engelsk
Tidsskrift	Chemical Communications
Vol/bind	58
Sider (fra-til)	12196-12199
ISSN	1359-7345
DOI	https://doi.org/10.1039/D2CC04294K
Status	Udgivet - 2022

Dokumenter og links

10.1039/D2CC04294K

SDU link

Tjek adgangen til materialet i Syddansk Universitetsbiblioteks søgemaskine

1 Ph.d.-afhandling

Modulation of Protein-Protein Interactions with Pre-Structured Peptides
Maas, M., 14. sep. 2022, Syddansk Universitet. Det Naturvidenskabelige Fakultet. 311 s.
Publikation: Afhandling › Ph.d.-afhandling

Citationsformater

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title = "Recognition of stapled histone H3K4me3 peptides by epigenetic reader proteins",

abstract = "The flexible N-terminal histone tails are a subject of numerous posttranslational modifications, including methylation. We report development of stapled histone peptides bearing trimethyllysine as ligands for epigenetic reader proteins. Stronger or weaker binding affinities have been observed for stapled histone peptides relative to linear histones, indicating that selectivity towards reader proteins can be achieved.",

author = "Peter Betlem and Maas, \{Marijn N.\} and Jim Middelburg and Pieters, \{Bas J. G. E.\} and Jasmin Mecinovi{\'c}",

year = "2022",

doi = "10.1039/D2CC04294K",

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T1 - Recognition of stapled histone H3K4me3 peptides by epigenetic reader proteins

AU - Betlem, Peter

AU - Maas, Marijn N.

AU - Middelburg, Jim

AU - Pieters, Bas J. G. E.

AU - Mecinović, Jasmin

PY - 2022

Y1 - 2022

N2 - The flexible N-terminal histone tails are a subject of numerous posttranslational modifications, including methylation. We report development of stapled histone peptides bearing trimethyllysine as ligands for epigenetic reader proteins. Stronger or weaker binding affinities have been observed for stapled histone peptides relative to linear histones, indicating that selectivity towards reader proteins can be achieved.

AB - The flexible N-terminal histone tails are a subject of numerous posttranslational modifications, including methylation. We report development of stapled histone peptides bearing trimethyllysine as ligands for epigenetic reader proteins. Stronger or weaker binding affinities have been observed for stapled histone peptides relative to linear histones, indicating that selectivity towards reader proteins can be achieved.

U2 - 10.1039/D2CC04294K

DO - 10.1039/D2CC04294K

M3 - Journal article

SN - 1359-7345

VL - 58

SP - 12196

EP - 12199

JO - Chemical Communications

JF - Chemical Communications

ER -

Recognition of stapled histone H3K4me3 peptides by epigenetic reader proteins

Abstract

Dokumenter og links

SDU link

Fingeraftryk

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Modulation of Protein-Protein Interactions with Pre-Structured Peptides

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