Real-life data patterns of C-reactive protein and albumin level trajectories around bacteremia

Kim Oren Gradel, Pedro Póvoa, Pernille Just Vinholt, Bjarne Magnussen, Court Pedersen, Thøger Gorm Jensen, Hans Jørn Kolmos, Annmarie Touborg Lassen

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Abstrakt

AIM: To assess trajectory patterns of C-reactive protein (CRP) and plasma albumin (PA) levels around bacteremia.

PATIENTS & METHODS: Population-based study, 2418 community-acquired bacteremia patients, CRP and PA specimens from 30 days before through 30 days after bacteremia (day 0). A pattern was based on specimen occurring or not in days -30/-1, 0, 1/7 or 8/30. Mean daily CRP and PA levels on day -30/30 were computed for pattern subgroups.

RESULTS & CONCLUSION: Mean CRP rose on day -5 and reached its peak on day 1. Mean steady PA on day -30/0 declined abruptly on day 1, increasing slowly thereafter. Trajectories did not differ between subgroups. We conclude that longitudinal analysis results can be extrapolated to all community-acquired bacteremia patients.

OriginalsprogEngelsk
TidsskriftBiomarkers in Medicine
Vol/bind12
Udgave nummer11
Sider (fra-til)1251–1259
ISSN1752-0363
DOI
StatusUdgivet - 30. nov. 2018

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