Real-life data patterns of C-reactive protein and albumin level trajectories around bacteremia

Kim Oren Gradel; Pedro Póvoa; Pernille Just Vinholt; Bjarne Magnussen; Court Pedersen; Thøger Gorm Jensen; Hans Jørn Kolmos; Annmarie Touborg Lassen

doi:10.2217/bmm-2018-0043

Real-life data patterns of C-reactive protein and albumin level trajectories around bacteremia

Kim Oren Gradel, Pedro Póvoa, Pernille Just Vinholt, Bjarne Magnussen, Court Pedersen, Thøger Gorm Jensen, Hans Jørn Kolmos, Annmarie Touborg Lassen

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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Abstract

AIM: To assess trajectory patterns of C-reactive protein (CRP) and plasma albumin (PA) levels around bacteremia.

PATIENTS & METHODS: Population-based study, 2418 community-acquired bacteremia patients, CRP and PA specimens from 30 days before through 30 days after bacteremia (day 0). A pattern was based on specimen occurring or not in days -30/-1, 0, 1/7 or 8/30. Mean daily CRP and PA levels on day -30/30 were computed for pattern subgroups.

RESULTS & CONCLUSION: Mean CRP rose on day -5 and reached its peak on day 1. Mean steady PA on day -30/0 declined abruptly on day 1, increasing slowly thereafter. Trajectories did not differ between subgroups. We conclude that longitudinal analysis results can be extrapolated to all community-acquired bacteremia patients.

Originalsprog	Engelsk
Tidsskrift	Biomarkers in Medicine
Vol/bind	12
Udgave nummer	11
Sider (fra-til)	1251–1259
ISSN	1752-0363
DOI	https://doi.org/10.2217/bmm-2018-0043
Status	Udgivet - 30. nov. 2018

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10.2217/bmm-2018-0043

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Citationsformater

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title = "Real-life data patterns of C-reactive protein and albumin level trajectories around bacteremia",

abstract = "AIM: To assess trajectory patterns of C-reactive protein (CRP) and plasma albumin (PA) levels around bacteremia.PATIENTS & METHODS: Population-based study, 2418 community-acquired bacteremia patients, CRP and PA specimens from 30 days before through 30 days after bacteremia (day 0). A pattern was based on specimen occurring or not in days -30/-1, 0, 1/7 or 8/30. Mean daily CRP and PA levels on day -30/30 were computed for pattern subgroups.RESULTS & CONCLUSION: Mean CRP rose on day -5 and reached its peak on day 1. Mean steady PA on day -30/0 declined abruptly on day 1, increasing slowly thereafter. Trajectories did not differ between subgroups. We conclude that longitudinal analysis results can be extrapolated to all community-acquired bacteremia patients.",

keywords = "Bacteremia, C-reactive protein, Community-acquisition, Daily mean level trajectories, Plasma albumin",

author = "Gradel, {Kim Oren} and Pedro P{\'o}voa and Vinholt, {Pernille Just} and Bjarne Magnussen and Court Pedersen and Jensen, {Th{\o}ger Gorm} and Kolmos, {Hans J{\o}rn} and Lassen, {Annmarie Touborg}",

year = "2018",

month = nov,

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doi = "10.2217/bmm-2018-0043",

language = "English",

volume = "12",

pages = "1251–1259",

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TY - JOUR

T1 - Real-life data patterns of C-reactive protein and albumin level trajectories around bacteremia

AU - Gradel, Kim Oren

AU - Póvoa, Pedro

AU - Vinholt, Pernille Just

AU - Magnussen, Bjarne

AU - Pedersen, Court

AU - Jensen, Thøger Gorm

AU - Kolmos, Hans Jørn

AU - Lassen, Annmarie Touborg

PY - 2018/11/30

Y1 - 2018/11/30

N2 - AIM: To assess trajectory patterns of C-reactive protein (CRP) and plasma albumin (PA) levels around bacteremia.PATIENTS & METHODS: Population-based study, 2418 community-acquired bacteremia patients, CRP and PA specimens from 30 days before through 30 days after bacteremia (day 0). A pattern was based on specimen occurring or not in days -30/-1, 0, 1/7 or 8/30. Mean daily CRP and PA levels on day -30/30 were computed for pattern subgroups.RESULTS & CONCLUSION: Mean CRP rose on day -5 and reached its peak on day 1. Mean steady PA on day -30/0 declined abruptly on day 1, increasing slowly thereafter. Trajectories did not differ between subgroups. We conclude that longitudinal analysis results can be extrapolated to all community-acquired bacteremia patients.

AB - AIM: To assess trajectory patterns of C-reactive protein (CRP) and plasma albumin (PA) levels around bacteremia.PATIENTS & METHODS: Population-based study, 2418 community-acquired bacteremia patients, CRP and PA specimens from 30 days before through 30 days after bacteremia (day 0). A pattern was based on specimen occurring or not in days -30/-1, 0, 1/7 or 8/30. Mean daily CRP and PA levels on day -30/30 were computed for pattern subgroups.RESULTS & CONCLUSION: Mean CRP rose on day -5 and reached its peak on day 1. Mean steady PA on day -30/0 declined abruptly on day 1, increasing slowly thereafter. Trajectories did not differ between subgroups. We conclude that longitudinal analysis results can be extrapolated to all community-acquired bacteremia patients.

KW - Bacteremia

KW - C-reactive protein

KW - Community-acquisition

KW - Daily mean level trajectories

KW - Plasma albumin

U2 - 10.2217/bmm-2018-0043

DO - 10.2217/bmm-2018-0043

M3 - Journal article

C2 - 30499693

SN - 1752-0363

VL - 12

SP - 1251

EP - 1259

JO - Biomarkers in Medicine

JF - Biomarkers in Medicine

IS - 11

ER -

Real-life data patterns of C-reactive protein and albumin level trajectories around bacteremia

Abstract

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